Early Life Fructose Exposure and Its Implications for Long-Term Cardiometabolic Health in Offspring

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 1 endocrinologydiseases
hyperglycemia 1 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
hypertriglyceridemia 3 endocrinologydiseases
obesity 12 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
amphetamine 1 endocrinologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
amphetamine 13200 anorexigenic signals (e.g., corticotropin-releasing hormone, thyrotropin-releasing hormone, cocaine- and amphetamine -regulated transcript, proopiomelanocortin) in offspring [[23]]. Third, fructose is transported passively
Select Disease Character Offset Disease Term Instance
diabetes mellitus 5392 consuming one or more sugar-sweetened soft drinks per day had an 83% greater risk of developing type 2 diabetes mellitus over the course of eight years compared with those who consumed less than one of these beverages per
hyperglycemia 9955 found that male offspring exposed to a maternal fructose-rich diet during pregnancy developed severe hyperglycemia , hypertriglyceridemia, hyperleptinemia, and augmented adipose tissue mass with hypertrophic adipocytes
hyperinsulinemia 16138 [[24]]Maternal 100 g/L fructose water during pregnancySprague Dawley ratsPostweaning day 5Hyperglycemia and hyperinsulinemia Elevated phosphoenolpyruvate carboxykinaseRawana et al. [[25]]Maternal 60% fructose throughout pregnancy
hypertriglyceridemia 9970 offspring exposed to a maternal fructose-rich diet during pregnancy developed severe hyperglycemia, hypertriglyceridemia , hyperleptinemia, and augmented adipose tissue mass with hypertrophic adipocytes [[28]]. Gray et al.
hypertriglyceridemia 11407 exposure during fetal and early postnatal development increases the susceptibility to hypertension, hypertriglyceridemia , insulin resistance, and possibly other metabolic disturbances later in life.3.3. Potential Mechanisms
hypertriglyceridemia 16715 JNKSaad et al. [[27]]Maternal 10% fructose during pregnancySprague Dawley rats60 daysHyperglycemia, hypertriglyceridemia , and hyperleptinemiaReduced adipocyte precursor cells numberAlzamendi et al. [[28]]Maternal 10% fructose
obesity 1027 intake of fructose, such as sugar-sweetened beverages and foods, has been linked to increased risk of obesity , type 2 diabetes, and cardiovascular disease in various populations. These deleterious effects of excess
obesity 1537 its implications for long-term cardiometabolic health in offspring.1. IntroductionThe prevalence of obesity and type 2 diabetes are increasing dramatically throughout the world, now considered a pandemic non-communicable
obesity 2120 health, and economic levels.In recent years, it has become increasingly clear that susceptibility to obesity and type 2 diabetes is strongly influenced by exposure to an adverse early life development environment
obesity 2534 postnatal period—are critical factors influencing the development of cardiometabolic disease, such as obesity , type 2 diabetes, and cardiovascular diseases in offspring [[2],[3],[4]]. Growing numbers of clinical
obesity 2758 studies suggest that maternal consumption of a diet high in fat and other potential nutrients promotes obesity and increased metabolic risk in offspring. However, little is known about the effects of fructose exposure
obesity 4746 thought that excessive intake of fructose from SSBs and foods has been linked to increased risk of obesity , type 2 diabetes, and cardiovascular disease in various populations [[11]]. One large clinical study
obesity 4919 populations [[11]]. One large clinical study showed a close parallel between the rise in HFCS intake and the obesity and diabetes epidemics in the United States [[12]]. Excess fructose consumption has been demonstrated
obesity 5170 [[13]], elevated low-density lipoprotein cholesterol (LDL-c), and triglycerides [[14]], leading to obesity , type 2 diabetes, and cardiovascular disease [[15]]. The Nurses’ Health Study cohort study showed
obesity 9721 developmental programming of adverse cardiometabolic health in offspring at 1 year of age, including obesity , hypertension, insulin resistance, increased liver fat infiltrates, and visceral adipose tissue [[27]].
obesity 14760 during critical periods of gestation, lactation, and early postnatal period. The increasing rates of obesity , prediabetes, and diabetes in individuals of reproductive age can initiate a vicious cycle, propagating
obesity 15068 fructose exposure and metabolic health can provide critical implications for the early prevention of obesity and type 2 diabetes, and ensure a healthier future for subsequent generations.Figure 1Early life fructose
obesity 16574 [[26]]Maternal 10% fructose during pregnancyC57BL/6J mouse1 year oldHypertension, insulin resistance, and obesity Increased expression of PTP1B and JNKSaad et al. [[27]]Maternal 10% fructose during pregnancySprague
type 2 diabetes mellitus 5385 women consuming one or more sugar-sweetened soft drinks per day had an 83% greater risk of developing type 2 diabetes mellitus over the course of eight years compared with those who consumed less than one of these beverages per

You must be authorized to submit a review.