Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 14 endocrinologydiseases
hyperglycemia 3 endocrinologydiseases
hypoglycemia 1 endocrinologydiseases
obesity 1 endocrinologydiseases
osteoporosis 6 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 2490 be proposed to explain the pathogenesis of sweet bones in diabetes mellitus, summarised in Figure 1. Insulin signaling has a metabolic and mitogenic effect on osteoblast cells. Current evidence in experimental
Select Disease Character Offset Disease Term Instance
diabetes mellitus 403 patients have increased fracture risk. The pathogenesis underlying the status of bone alterations in diabetes mellitus is not completely understood but is multifactorial. The major deficits appear to be related to a deficit
diabetes mellitus 767 decreased numbers of osteoclasts due to abnormal insulin signaling pathway. Other prominent features of diabetes mellitus are an increased urinary excretion of calcium and magnesium, accumulation of advanced glycation end
diabetes mellitus 1128 assessed for risk factors for fractures and osteoporosis. The pathogenesis of the bone alterations in diabetes mellitus as well as their molecular mechanisms needs further study. 1. IntroductionDiabetes mellitus is a common
diabetes mellitus 1633 addition to many other organs. However, the status of bones as well as their disorders in patients with diabetes mellitus has received very little attention. This is surprising because bone disease in diabetes mellitus is
diabetes mellitus 1730 with diabetes mellitus has received very little attention. This is surprising because bone disease in diabetes mellitus is probably as old as the disease itself since descriptions of bone disease in diabetes can be traced
diabetes mellitus 2448 BonesThere are different mechanisms that can be proposed to explain the pathogenesis of sweet bones in diabetes mellitus , summarised in Figure 1.Insulin signaling has a metabolic and mitogenic effect on osteoblast cells.
diabetes mellitus 3580 during critical growth period [[11]]. Altered vitamin D and calcium metabolism due to hyperglycemia in diabetes mellitus can lead to low bone mass and increase chances of fractures [[12], [13]].A number of studies demonstrated
diabetes mellitus 7955 these confounding variables may have independent negative impacts upon bone mineral acquisition in diabetes mellitus and, ultimately, on peak bone mass. On the other hand, low levels of insulin associated with T1D and
diabetes mellitus 9088 normocalcaemia under these conditions [[40]].Delayed and impaired fracture's healing in patients with diabetes mellitus has been described in many studies [[41], [42]]. Diabetes impairs the production of critical growth
diabetes mellitus 10070 [47]].3. Prevention of Sweet BonesPrevention of any disease is a laudable goal. When this is applied to diabetes mellitus , it gains further importance because of the fact that this disease is gaining epidemic proportion and
diabetes mellitus 10792 retinopathy and help to maintain vision [[50]]. Deficiencies of calcium and vitamin D in patients with diabetes mellitus should be treated. Vitamin D supplementation should ensure a serum 25-hydroxyvitamin D level of 75 nmol/L
diabetes mellitus 11189 activity and bone formation [[52]]. Assessment of osteoporosis is similar in patients with and without diabetes mellitus . Selection of specific osteoporosis drugs is frequently based on comorbidities [[53]] (Figure 2).4.
diabetes mellitus 11373 comorbidities [[53]] (Figure 2).4. ConclusionNevertheless, awareness of sweet bone in a patient with diabetes mellitus is important in clinical practice. Early recognition and appropriate intervention are essential in avoiding
diabetes mellitus 11823 Densitometry and The National Osteoporosis Foundation. The pathogenesis of the bone alterations in diabetes mellitus as well as their molecular mechanisms needs further study.Figure 1The pathogenesis of bone alteration
hyperglycemia 3463 because of lower insulin-like growth factor 1 levels and the catabolic effects of frequent uncontrolled hyperglycemia during critical growth period [[11]]. Altered vitamin D and calcium metabolism due to hyperglycemia
hyperglycemia 3563 hyperglycemia during critical growth period [[11]]. Altered vitamin D and calcium metabolism due to hyperglycemia in diabetes mellitus can lead to low bone mass and increase chances of fractures [[12], [13]].A number
hyperglycemia 7355 underlying hyperinsulinaemia, suggests the involvement of other potential pathogenic influences (e.g., hyperglycemia , diabetic complications, and lifestyle factors) on bone [[7]]. In the experimental model, the skeletal
hypoglycemia 9811 patients may not be related to the systemic effect of diabetes on the skeleton but rather may be due to hypoglycemia , neuropathy, loss of proprioception balance, and coordination that are common in this disease and an
obesity 2694 experimental models with impaired insulin signaling exhibited both metabolic and bone phenotypes, including obesity , insulin intolerance/resistance, and symptoms of low bone mass [[6]] and the qualitatively different
osteoporosis 1070 metabolism, and structure). Every diabetic patient should be assessed for risk factors for fractures and osteoporosis . The pathogenesis of the bone alterations in diabetes mellitus as well as their molecular mechanisms
osteoporosis 3724 and increase chances of fractures [[12], [13]].A number of studies demonstrated that osteopenia and osteoporosis are frequent complications of T1D [[14]], as a result of increased oxidative stress [[15]], as well
osteoporosis 5554 T2D [[24]]. It has been documented that T2D cases with high bone turnover assuredly predisposed to osteoporosis [[25]]. Obesity prevalent in T2D is strongly associated with higher BMD probably through mechanical
osteoporosis 11136 causes bone loss accompanied by decreased osteoblast activity and bone formation [[52]]. Assessment of osteoporosis is similar in patients with and without diabetes mellitus. Selection of specific osteoporosis drugs
osteoporosis 11230 Assessment of osteoporosis is similar in patients with and without diabetes mellitus. Selection of specific osteoporosis drugs is frequently based on comorbidities [[53]] (Figure 2).4. ConclusionNevertheless, awareness of
osteoporosis 11629 consequences in diabetic patient.Every diabetic patient should be assessed for risk factors for fractures and osteoporosis according to the guidelines established by The International Society for Clinical Densitometry and The

You must be authorized to submit a review.