PCSK9 targets important for lipid metabolism

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Annotation Summary

Term Occurence Count Dictionary
lipodystrophy 1 endocrinologydiseases
familial hypercholesterolemia 1 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
hypothyroidism 1 endocrinologydiseases

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familial hypercholesterolemia 23107 with type 2 diabetes [[77]]. Interestingly, PSCK9 inhibition reduces Lp(a) in patient with homozygous familial hypercholesterolemia despite their lack or dysfunction of the LDLR. Therefore the question arises that the regulation of
hyperinsulinemia 1120 extracellular inactivation and clearance. Many comorbidities (kidney insufficiency, hypothyreoidism, hyperinsulinemia , inflammation) modify PCSK9 expression and release. Two humanized antibodies directed against extracellular
hypothyroidism 12910 LDL-C concentration [[50]].Hypothyroidism increases PCSK9 expression in patient with thyroid cancer and hypothyroidism is associated with an increase in LDL-C and apolipoprotein B concentrations [[65]].Hyperinsulinemia
lipodystrophy 12731 [[36], [92], [93]].Lipodystrophy increases PCSK9 concentrations in females and leptin treatment (to cure lipodystrophy ) reduces the plasma PCSK9 concentration in parallel with the LDL-C concentration [[50]].Hypothyroidism

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