Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications.

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thrombosis 1 angiologydiseases
vascular disease 5 angiologydiseases

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thrombosis 21068 PAI-1 levels is highly prevalent in diabetic patients, thus contributing to the increased risk of athero thrombosis and CVD in these subjects [[91],[92]]. These observations further suggest the active participation of
vascular disease 1155 accumulation of AGEs in diabetes-associated disorders such as diabetic microangiopathy, atherosclerotic cardio vascular disease s, Alzheimer’s disease and osteoporosis. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
vascular disease 2496 diabetes. From the standpoint of patients’ quality of life, diabetes is in a sense one of the cardio vascular disease s. Indeed, diabetic nephropathy and retinopathy are one of the leading causes of end-stage renal failure
vascular disease 2778 neuropathy could account for disabilities in patients with diabetes [[1]-[3]]. Atherosclerotic cardio vascular disease s (CVD) account for about 60% of death in diabetic subjects [[4]]. Furthermore, even after adjusting
vascular disease 6700 (IMT) and subsequently reduced the risk of nonfatal myocardial infarction, stroke, or death from cardio vascular disease by 57% 11 years after the end of the trials [[16],[17]]. The major adverse effect of intensive therapy
vascular disease 12170 progression of diabetes-associated disorders such as diabetic microangiopathy, atherosclerotic cardio vascular disease s, Alzheimer’s disease and osteoporosis [[8],[9],[22],[35]-[40]]. Moreover, AGEs are reported to up-regulate

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