Properdin: a tightly regulated critical inflammatory modulator

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Annotation Summary

Term Occurence Count Dictionary
aortic aneurysm 1 angiologydiseases
clopidogrel 1 angiologydiseasesdrugs
thrombosis 2 angiologydiseases
vascular disease 1 angiologydiseases
abdominal aortic aneurysm 1 angiologydiseases
aneurysm 1 angiologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
clopidogrel 49021 therapeutics that inhibit platelet activation (limiting all platelet/neutrophil interactions,166 such as clopidogrel ), are associated with rare, but potentially life‐threatening bleeding phenotypes.167The studies by
Select Disease Character Offset Disease Term Instance
abdominal aortic aneurysm 29797 functions of properdin in vivo and ex vivo. Zhou et al.99 used an indirect approach in a murine model of abdominal aortic aneurysm (AAA) to differentiate between properdin as an initiator or regulator of alternative pathway activity.
aneurysm 29814 in vivo and ex vivo. Zhou et al.99 used an indirect approach in a murine model of abdominal aortic aneurysm (AAA) to differentiate between properdin as an initiator or regulator of alternative pathway activity.
aortic aneurysm 29807 properdin in vivo and ex vivo. Zhou et al.99 used an indirect approach in a murine model of abdominal aortic aneurysm (AAA) to differentiate between properdin as an initiator or regulator of alternative pathway activity.
thrombosis 33368 aggregates.Platelet/granulocyte aggregates6.1Platelets not only are key mediators of vascular hemostasis as well as pathologic thrombosis , but they secrete multiple proinflammatory mediators, many of which recruit and activate neutrophils.110
thrombosis 46385 decreased Factor H cell‐surface protection, increased PGA formation may account for part of the excessive thrombosis and inhibition of properdin function may have beneficial effects.Hamad et al.6 also described a novel
vascular disease 50676 evidence that has independently suggested roles for both granulocytes169 and complement170 in cardio vascular disease , an example of a set of diseases associated with increased circulating PGAs.135 Additionally, an increase

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