l-Citrulline Supplementation: Impact on Cardiometabolic Health

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ischemia 2 angiologydiseases
vascular disease 6 angiologydiseases

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ischemia 20610 formation of hydroxyl radicals (HO−) [[66]]. Hydroxyl radical formation is highly upregulated during ischemia /low oxygen availability in tissues supplied by atherosclerotic blood vessels [[62]]. l-citrulline can
ischemia 24425 differences between an acute combined nitrate-citrulline supplement and placebo were observed in post- ischemia vascular responses, as measured by near-infrared spectroscopy (NIRS) [[82]]. Other studies in healthy
vascular disease 2649 diseases including hypertension, atherosclerosis, insulin resistance, type 2 diabetes (T2D), and cardio vascular disease [[1],[2],[3],[4]]. In endothelial cells, NO is synthesized from l-arginine (precursor) by endothelial-nitric
vascular disease 17240 with obesity-induced insulin resistance, is thought to be a major factor in the development of cardio vascular disease [[45]]. Dietary factors, such as high fat/high cholesterol diet, adipocyte derived factors, and aging
vascular disease 17519 inflammation and further exacerbated endothelial dysfunction, contributing to the development of cardio vascular disease [[45],[55],[56],[57],[58]]. Studies in rats fed a high fat/high cholesterol diet observed an elevation
vascular disease 34888 of cardiovascular events and nephropathies in patients with T2D [[111],[112]]. The pathogenesis of vascular disease originates primarily from endothelial dysfunction [[113],[114],[115]]. Endothelial dysfunction in patients
vascular disease 50301 pharmaceutical drugs for the treatment of hypertension, atherosclerosis, insulin resistance, T2D, and cardio vascular disease should also be investigated, as some of these drugs have been shown to affect citrulline metabolism
vascular disease 51803 impact hypertension, atherosclerosis, inflammation, insulin resistance, type 2 diabetes, and cardio vascular disease . Emerging evidence also suggests that l -citrulline itself can positively impact skeletal muscle and

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