Novel insights into DNA methylation and its critical implications in diabetic vascular complications.

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vascular disease 2092 macrovascular complications such as atherosclerosis, diabetic cardiomyopathy (DCM) and other cardio vascular disease s and microvascular complications such as nephropathy and retinopathy [[3],[4]]. Diabetic cardiovascular
vascular disease 2204 diseases and microvascular complications such as nephropathy and retinopathy [[3],[4]]. Diabetic cardio vascular disease s are the main cause of disability and death of diabetic patients [[5]]. It reports that the risk of
vascular disease 8160 number of key processes and metabolic diseases, such as obesity [[23]], type 2 diabetes [[24]] and cardio vascular disease s [[25]].Figure 2Molecular mechanisms of DNA methylationDNA methylation is exerted by DNMTs at the 5′-position
vascular disease 8661 vascular complicationsDNA methylation and atherosclerosisIt is well known that atherosclerotic cardio vascular disease is the major cause of morbidity and mortality in diabetes. Atherosclerosis occurs earlier and with greater
vascular disease 9845 synthase, hypoxia-inducible factor-1a and matrix metalloproteinases [[29]]. Other risk factors of cardio vascular disease s, such as hyperhomocysteinaemia, hypercholesterolaemia and inflammation have also been implicated in

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