Best Practices in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia: A Focus on Asparaginase

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Term Occurence Count Dictionary
doxorubicin 1 angiologydiseasesdrugs
methotrexate 1 angiologydiseasesdrugs
prednisone 1 angiologydiseasesdrugs
thrombosis 5 angiologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
doxorubicin 15386 consists of two alternating cycles: Cycle A, characterized by fractionated cyclophosphamide, vincristine, doxorubicin , and dexamethasone, and Cycle B, characterized by high-dose methotrexate and cytarabine.[13],[59] A
methotrexate 15458 cyclophosphamide, vincristine, doxorubicin, and dexamethasone, and Cycle B, characterized by high-dose methotrexate and cytarabine.[13],[59] A number of recent studies have retrospectively compared patients treated on
prednisone 11957 trials included a five-drug remission induction regimen (cyclophosphamide, daunorubicin, vincristine, prednisone , and asparaginase). Patients in the CCG trials were treated with either a standard CCG protocol or an
Select Disease Character Offset Disease Term Instance
thrombosis 25383 mark in this study included pancreatitis (39%), clinical allergy (19%), and central nervous system thrombosis (12%).The CALGB-9511 study measured asparaginase activity in 85 adult patients (aged 17–71 years)
thrombosis 28242 with thrombotic complications occurring in up to 34% of adult patients in one study.[105] Deep venous thrombosis should be managed with anticoagulation therapy, and it is recommended that asparaginase be temporarily
thrombosis 29740 Years (N = 51)[107] Grade 1 or 2Grade 3 or 4Toxicitynn%Pancreatitis0713.7Allergy235.9Deep venous thrombosis 0815.7Bleeding512Transaminitis193262.7Hyperbilirubinemia301631.3Hyperglycemia291733.3Hypertriglyceridemia6917.6Fatigue3447.8Neuropathy1012Vomiting1923.9Nausea3435.9Diarrhea1600Constipation1800Headache2712Edema600Reprinted
thrombosis 33587 similar for patients aged 16–40 years and younger than 10 years (3.4% and 3.0%, respectively). Rates of thrombosis were slightly higher in AYA patients, with thrombosis reported in 4.1% of AYA patients compared with
thrombosis 33641 years (3.4% and 3.0%, respectively). Rates of thrombosis were slightly higher in AYA patients, with thrombosis reported in 4.1% of AYA patients compared with 1.3% of children younger than 10 years of age. All patients

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