Molecular Pathways Regulating Macrovascular Pathology and Vascular Smooth Muscle Cells Phenotype in Type 2 Diabetes

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vascular disease 725 reaching a pandemic proportion in developed countries and a major risk factor for almost all cardio vascular disease s and their adverse clinical manifestations. T2DM leads to several macrovascular and microvascular alterations
vascular disease 892 leads to several macrovascular and microvascular alterations that influence the progression of cardio vascular disease s. Vascular smooth muscle cells (VSMCs) are fundamental players in macrovascular alterations of T2DM
vascular disease 3101 complications, it is surprising that less or minimal attention has been given to T2DM-related macro vascular disease and the role of vascular smooth muscle cells (VSMCs), the predominant cell population in the arterial
vascular disease 5978 causing detrimental changes in their phenotype and function (Figure 1). Increased susceptibility to cardio vascular disease s in T2DM patients suggests that a pathological phenotype of VSMCs is worthy of detailed study [[24]].
vascular disease 13533 as a potential therapeutic target. Interferon regulatory factor-1 (IRF-1) is a molecular mediator of vascular disease s. Several studies provided evidences that IRF-1 reduces vascular cell growth under normal glucose conditions,
vascular disease 15289 AGE accumulation induces the increased production of ROS. ROS accumulation plays a central role in vascular disease , including atherosclerosis and restenosis. AGE accumulation activated NF-κB in many cell types, in

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