Role of Oxidative Stress in Drug-Induced Kidney Injury

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Annotation Summary

Term Occurence Count Dictionary
tacrolimus 2 nephrologydiseasesdrugs
acute kidney injury 3 nephrologydiseases
chronic kidney disease 1 nephrologydiseases
interstitial nephritis 3 nephrologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
tacrolimus 3277 equal to 50% within 48 h [[6]]. However, in some cases, this definition is not applied. For example, tacrolimus -induced AKI in liver transplant recipients is diagnosed by an increase in Scr level of 50% within a
tacrolimus 3442 diagnosed by an increase in Scr level of 50% within a continuous 96 h, because the changes in Scr caused by tacrolimus is gradual and difficult to evaluate according to the AKIN criteria [[7]]. On the other hand, contrast-induced
Select Disease Character Offset Disease Term Instance
acute kidney injury 1038 drug-induced kidney injury is a serious problem in clinical practice and accounts for roughly 20% of cases of acute kidney injury (AKI) among hospitalized patients. Therefore, its early detection is becoming more important. Usually,
acute kidney injury 2748 drug-induced kidney injury is a serious problem in clinical practice and accounts for 19%–26% of cases with acute kidney injury (AKI) among hospitalized patients [[4]]. Moreover, AKI causes a severe condition associated with high
acute kidney injury 19560 glutathione reductase; GSSG: glutathione disulfide.ijms-17-01826-t001_Table 1Table 1Drugs responsible for acute kidney injury .Type of DamageDrugPharmacological ClassReferencesATNCisplatinChemotherapeutic agents[[9]]IfosfamideChemotherapeutic
chronic kidney disease 2910 Moreover, AKI causes a severe condition associated with high probabilities of developing progressive chronic kidney disease or end-stage renal disease, thus leading to high mortality rates [[5]]. Currently, AKI is defined by
interstitial nephritis 1259 Usually, drug-induced AKI consists of two patterns of renal injury: acute tubular necrosis (ATN) and acute interstitial nephritis (AIN). Whereas AIN develops from medications that incite an allergic reaction, ATN develops from direct
interstitial nephritis 3709 (within 12 h) [[8]].2. Drugs Responsible for AKIAKI includes acute tubular necrosis (ATN) and acute interstitial nephritis (AIN). Table 1 shows commonly prescribed drugs which are known to cause AKI, which is due to ATN or
interstitial nephritis 20634 inhibitors[[40]]NivolumabImmune check point inhibitors[[40]]ATN: acute tubular necrosis; AIN: acute interstitial nephritis ; NSAIDs: nonsteroidal anti-inflammatory drugs

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