Experimental glomerulonephritis induced by hydrocarbon exposure: a systematic review

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glomerulonephritis 31 nephrologydiseases
methylprednisolone 1 nephrologydiseasesdrugs
prednisolone 1 nephrologydiseasesdrugs

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methylprednisolone 10078 directed against extrarenal T-cells were the findings that pre-treatment with irradiation [[25],[26]] or methylprednisolone [[25]] abrogated proteinuria, and also that radiolabeled MVE-2 was found to be located mainly to the
prednisolone 10084 against extrarenal T-cells were the findings that pre-treatment with irradiation [[25],[26]] or methyl prednisolone [[25]] abrogated proteinuria, and also that radiolabeled MVE-2 was found to be located mainly to the
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glomerulonephritis 34 Title: BMC NephrologyExperimental glomerulonephritis induced by hydrocarbon exposure: A systematic reviewUffe Ravnskov1Magle Stora Kyrkogata 9, S-22350 Lund,
glomerulonephritis 326 12/2005AbstractBackgroundMuch epidemiological evidence suggests that hydrocarbon exposure may induce glomerulonephritis and worsen its course in many patients. The mechanisms are unknown, however, no specific microscopic
glomerulonephritis 653 mainly. Studying experimental animals may best answer these questions, and as no systematic review of glomerulonephritis produced experimentally by hydrocarbon exposure has been performed previously, I found it relevant to
glomerulonephritis 858 it relevant to search for and analyse such studies.MethodsAnimal experiments having mimicked human glomerulonephritis by hydrocarbon exposure were sought on Medline and ToxnetResultsTwenty-six experiments using thirteen
glomerulonephritis 1125 Several human subtypes were observed including IgA nephritis, mesangial, proliferative and extracapillary glomerulonephritis , focal and focal-segmental sclerosis, minimal change nephropathy, anti-GBM and anti-TBM nephritis, and
glomerulonephritis 1247 focal and focal-segmental sclerosis, minimal change nephropathy, anti-GBM and anti-TBM nephritis, and glomerulonephritis associated with peiarteritis nodosa. Glomerular proteinuria was seen in 10/12 experiments that included
glomerulonephritis 1909 all.ConclusionThese experiments are in accord with epidemiological evidence that hydrocarbon exposure may cause glomerulonephritis and worsen renal function. Probable mechanisms include an induction of autologous antibodies and a disturbance
glomerulonephritis 2330 glomerular immune complex formation was unlikely, but may rather have been a secondary phenomenon. As most glomerulonephritis subgroups were seen and as some of the hydrocarbons produced more than one subgroup, the microscopic
glomerulonephritis 2611 causation of his disease. By the same reason, the lack of a specific histological pattern in patients with glomerulonephritis assumed to have been caused by hydrocarbon exposure is not contradictive.BackgroundThere is much observational
glomerulonephritis 2882 solvents, paints, glues, fuels, motor exhausts and other environmental hydrocarbon contaminants may induce glomerulonephritis and also worsen renal function in a large number of patients [[1]-[3]]. Indeed, this hypothesis satisfies
glomerulonephritis 3454 have shown tubular damage mainly, and that no specific glomerular pattern of hydrocarbon-associated glomerulonephritis has been identified in human beings. Glomerulonephritis has indeed been produced in a few experiments
glomerulonephritis 3864 studies and found twenty-six.MethodsUsing Medline and Toxnet I sought experiments that had produced glomerulonephritis by exposing animals to hydrocarbons. The search strategy included the formula (glomerulonephritis OR
glomerulonephritis 3962 produced glomerulonephritis by exposing animals to hydrocarbons. The search strategy included the formula ( glomerulonephritis OR glomerulopathy) AND experiment* AND (hydrocarbon* OR solvent* OR X) where X was substituted by a
glomerulonephritis 4627 authors had noted microscopical changes in the kidneys of the animals similar to those seen in human glomerulonephritis after having exposed them to various hydrocarbons [[4]-[28]]. One experiment was reported in two papers
glomerulonephritis 6108 [[13],[16]], crescentic [[6],[14]], proliferative [[6],[20]] and focal segmental proliferative [[19],[20]] glomerulonephritis , focal [[18]], focal segmental [[17],[22],[27]] and total [[11],[26]] glomerular sclerosis, minimal
glomerulonephritis 6294 [[11],[26]] glomerular sclerosis, minimal change nephropathy [[11],[20],[25]], anti-TBM nephritis [[19]] and glomerulonephritis associated with periarteritis nodosa [[9]]. A summary of the findings is given in Additional file 1.DiscussionAs
glomerulonephritis 6483 is given in Additional file 1.DiscussionAs shown in this review glomerular changes similar to human glomerulonephritis have been found in 26 expeiments by exposing animals to hydrocarbons, a strong support to the view,
glomerulonephritis 6632 expeiments by exposing animals to hydrocarbons, a strong support to the view, that such exposure may induce glomerulonephritis in human beings. The histological documentation in the early studies was cursory, but the more recent
glomerulonephritis 6919 and/or IM also, have mimicked most of the human subgroups successfully. Few models of experimental glomerulonephritis using manipulation of the immune system have resulted in more harm to the kidneys than trace or transient
glomerulonephritis 7357 laboratory measurements, resulted in severe proteinuria and renal failure.Up to five different subgroups of glomerulonephritis were seen after exposure to the same hydrocarbon. In some of the models it was obvious that they represented
glomerulonephritis 8176 by one of the impurities.One of the arguments against the idea that hydrocarbon exposure may cause glomerulonephritis has been that a specific glomerular pattern has never been identified, but as almost all subgroups were
glomerulonephritis 8458 untenable.The experiments offer several explanations regarding the mechanisms behind hydrocarbon-induced glomerulonephritis . Each of them may be sufficient by itself, although a complex co-operation seems more likely.By combining
glomerulonephritis 11091 trapping of circulating macromolecules. That proximal tubular damage may play a role in the causation of glomerulonephritis is suggestive also from the fact that most nephritogenic chemicals, for instance mercury, gold, silicium
glomerulonephritis 11341 tubulotoxic as well, and that a large number of studies have found that the renal function and the course in glomerulonephritis is strongly predicted by the degree of tubulointerstitial damage, but not by the degree of glomerular
glomerulonephritis 11839 predisposition is necessary. This finding may also explain why many similar experiments have failed to produce glomerulonephritis .The animal experiments are in accordance with the results from many cross-sectional and case-control
glomerulonephritis 12090 workers exposed regularly to hydrocarbons significantly more had urinary findings typical of early glomerulonephritis than had age and sex-matched control individuals. The findings included a pathological urinary sediment,
glomerulonephritis 12485 18 case-control studies odds ratio for exposure was 1.1 or lower in four studies that included early glomerulonephritis only, whereas in all studies that included patients with failure the ratio was 1.7 or, more often, much
glomerulonephritis 12748 included patients with end-stage renal failure only [[3]].ConclusionThe successful imitation of human glomerulonephritis achieved in 26 experiments by exposing animals to various hydrocarbons is a further confirmation, suggested
glomerulonephritis 12940 a further confirmation, suggested by numerous observational studies, that such exposure may induce glomerulonephritis in predisposed individuals. To convert this knowledge to benefit for the patients demands more research,
glomerulonephritis 13397 in a small prospective one [[3]], it would be the final proof that hydrocarbon exposure is causal in glomerulonephritis . At the same time it may become a major improvement in the prevention of terminal renal failure because
glomerulonephritis 13884 a marker for hydrocarbon exposure, such studies demand a thorough questioning of all patients with glomerulonephritis for possible environmental hazards, preferably in co-operation with experts in occupational medicine.Competing

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