The Vitamin K Metabolome in Chronic Kidney Disease

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chronic kidney disease 5 nephrologydiseases

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chronic kidney disease 505 (collection): 8/2018AbstractThe purpose of this review is to summarize the research to date on the impact of chronic kidney disease (CKD) on the vitamin K metabolome. Vitamin K-dependent proteins contribute to cardiovascular disease
chronic kidney disease 9897 UBIAD1.To the best of our knowledge, tissue levels of K1 and MK-4 have not been measured in patients with chronic kidney disease . In a rat model of experimental CKD, significant differences with respect to the concentrations of K
chronic kidney disease 18120 latter study and the previous ones could be attributed to differences in the assay used.Patients with chronic kidney disease also demonstrate significantly increased levels of undercarboxylated osteocalcin (ucOC) levels compared
chronic kidney disease 18981 [[3],[4],[6],[7],[28]]. In CKD patients, the level of OC typically correlates very strongly with other biomarkers of the chronic kidney disease -mineral bone disorder (CKD-MBD) including phosphate and parathyroid hormone [[6]]. Further, retention
chronic kidney disease 20521 to respond to dietary supplementation in hemodialysis patients [[7]].Taken together, patients with chronic kidney disease appear to consume an adequate amount of vitamin K yet exhibit very high levels of under-carboxylated

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