Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature

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Term Occurence Count Dictionary
tacrolimus 4 nephrologydiseasesdrugs
zoledronic acid 1 nephrologydiseasesdrugs
focal segmental glomerulosclerosis 6 nephrologydiseases
furosemide 1 nephrologydiseasesdrugs
nephrotic syndrome 9 nephrologydiseases
prednisone 2 nephrologydiseasesdrugs

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furosemide 6775 syndrome, ibandronate was discontinued. She initially underwent treatment with lisinopril, simvastatin and furosemide . However, after one month, she had no improvement of protenuria. Prednisone was started at 60 mg daily.
prednisone 1244 ibandronate-associated CFSGS, proteinuria appears to be at least partially reversible with the treatment of prednisone and/or tacrolimus if the syndrome is recognized early and ibandronate is stopped.BackgroundBisphosphonates
prednisone 12349 CFSGS and nephrotic syndrome. Proteinuria appears to be partially reversible with the treatment of prednisone and/or tacrolimus if the syndrome is recognized early and ibandronate is stopped. We did not have a
tacrolimus 1031 proven by biopsy. There was no improvement 1 month after ibandronate was discontinued. Prednisone and tacrolimus were started and she experienced a decreased in proteinuria.ConclusionIn patient who develops ibandronate-associated
tacrolimus 1262 CFSGS, proteinuria appears to be at least partially reversible with the treatment of prednisone and/or tacrolimus if the syndrome is recognized early and ibandronate is stopped.BackgroundBisphosphonates are widely
tacrolimus 7080 indicative of some improvement but still within the nephrotic range. Therefore, a calcineurin inhibitor, tacrolimus 1 mg twice daily was started in August 2011 and continued through October 2013. Prednisone was tapered
tacrolimus 12367 nephrotic syndrome. Proteinuria appears to be partially reversible with the treatment of prednisone and/or tacrolimus if the syndrome is recognized early and ibandronate is stopped. We did not have a follow up biopsy to
zoledronic acid 11528 Update committee recommends that serum creatinine should be monitored before each dose of pamidronate or zoledronic acid per FDA-approved labeling [[23]]. Serum calcium, electrolytes, phosphate, magnesium, and hematocrit/hemoglobin
Select Disease Character Offset Disease Term Instance
focal segmental glomerulosclerosis 28 Title: BMC CancerCollapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literatureNing JiaFionnuala
focal segmental glomerulosclerosis 595 cancer patients with bone metastasis. One of the patterns of bisphosphonate-induced nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological variant, collapsing focal segmental glomerulosclerosis (CFSGS).Case presentationWe
focal segmental glomerulosclerosis 678 nephrotoxicity is focal segmental glomerulosclerosis (FSGS) or its morphological variant, collapsing focal segmental glomerulosclerosis (CFSGS).Case presentationWe describe a breast cancer patient who developed heavy proteinuria (protein/creatinine
focal segmental glomerulosclerosis 3383 disease [[7]]. One of the patterns of nephrotoxicity with bisphophonates is the development of the focal segmental glomerulosclerosis (FSGS) or its morphological variant the collapsing focal segmental glomerulosclerosis (CFSGS), which
focal segmental glomerulosclerosis 3469 development of the focal segmental glomerulosclerosis (FSGS) or its morphological variant the collapsing focal segmental glomerulosclerosis (CFSGS), which typically presents with nephrotic syndrome and renal insufficiency [[7]]. To our knowledge,
focal segmental glomerulosclerosis 10468 case of massive proteinuria and acute renal failure after alendronate administration in a patient with focal segmental glomerulosclerosis [[18]]. Stratton et al. reported two cases of relapse of steroid-dependent nephrotic syndrome triggered
nephrotic syndrome 841 describe a breast cancer patient who developed heavy proteinuria (protein/creatinine ratio 9.1) and nephrotic syndrome following treatment with oral ibandronate for 29 months. CFSGS was proven by biopsy. There was no improvement
nephrotic syndrome 3543 morphological variant the collapsing focal segmental glomerulosclerosis (CFSGS), which typically presents with nephrotic syndrome and renal insufficiency [[7]]. To our knowledge, no patients with CFSGS and nephrotic syndrome associated
nephrotic syndrome 3638 with nephrotic syndrome and renal insufficiency [[7]]. To our knowledge, no patients with CFSGS and nephrotic syndrome associated with ibandronate have been described in the literature before.Case presentationA 44-year-old
nephrotic syndrome 4651 (0.7 mg/dl) which had been consistently normal before. She had no hypertension history. A diagnosis of nephrotic syndrome was made.Serological evaluation for HIV, hepatitis C, hepatitis B virus, antibodies to nuclear antigens
nephrotic syndrome 6658 capillary surface area (Fig. 1c). No electron dense deposit was identified. After the diagnosis of nephrotic syndrome , ibandronate was discontinued. She initially underwent treatment with lisinopril, simvastatin and furosemide.
nephrotic syndrome 8197 glomerular basement membrane. 4800 X magnificationDiscussionWe report a rare case of collapsing FSGS and nephrotic syndrome associated with the administration of oral ibandronate. Ibandronate is a single nitrogen-containing
nephrotic syndrome 10578 segmental glomerulosclerosis [[18]]. Stratton et al. reported two cases of relapse of steroid-dependent nephrotic syndrome triggered by etidronate [[19]]. Proteinuria is thus a known feature of bisphosphonate-associated nephrotoxicity.
nephrotic syndrome 10725 [[19]]. Proteinuria is thus a known feature of bisphosphonate-associated nephrotoxicity. In many cases, nephrotic syndrome associated with bisphosphonate is partially or completely reversible following discontinuation of bisphosphonate
nephrotic syndrome 12260 than zoledronate [[24]].ConclusionWe report an unusual case of oral ibandronate-associated CFSGS and nephrotic syndrome . Proteinuria appears to be partially reversible with the treatment of prednisone and/or tacrolimus if

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