Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
acute kidney injury 9 nephrologydiseases
chronic kidney disease 3 nephrologydiseases
sodium bicarbonate 6 nephrologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
sodium bicarbonate 3705 and free hemoglobin [[7],[16]]. An experimental study demonstrated that urinary alkalinization with sodium bicarbonate (SBIC) could prevent oxidant injury to the kidney by eliminating oxygen species [[17]]. Accordingly,
sodium bicarbonate 5138 library were systematically searched from inception to 15 March 2014, with the following keywords: sodium bicarbonate , acute kidney injury, and cardiac surgery. No limitation was enhanced. To include additional eligible
sodium bicarbonate 13035 GFR, glomerular filtration rate; IV, intravenous injection; RCT, randomized controlled trial; SBIC, sodium bicarbonate ; sCr, serum creatinine. asCr criteria: an increase in sCr >25% or 0.5 mg/dl from baseline to peak value
sodium bicarbonate 14787 randomized controlled trials included [[2]–[6]]. CI, confidence interval; RR, relative risk; SBIC, sodium bicarbonate .Sensitivity analysisSince moderate heterogeneity was observed among the studies for the CSA-AKI, sensitivity
sodium bicarbonate 16275 chronic kidney disease; CSA-AKI, cardiac surgery-associated acute kidney injury; RR, relative risk; SBIC, sodium bicarbonate .Secondary outcomesCompared with placebo, SBIC did not alter the clinical outcomes of HLOS (WMD = 0.23 days;
sodium bicarbonate 17457 randomized controlled trials included [[3]–[6]]. CI, confidence interval; RR, relative risk; SBIC, sodium bicarbonate .Figure 6Forest plot for the meta-analysis of the duration of ventilation. Four randomized controlled
Select Disease Character Offset Disease Term Instance
acute kidney injury 87 Title: Critical CareSodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury : a systematic review and meta-analysisHong-Tao TieMing-Zhu LuoMing-Jing LuoMin ZhangQing-Chen WuJing-Yuan
acute kidney injury 439 /2014AbstractIntroductionSodium bicarbonate (SBIC) was reported to be a promising approach to prevent cardiac surgery-associated acute kidney injury (CSA-AKI). However, the results remain controversial. We conducted a systematic review and meta-analysis
acute kidney injury 2897 With increasing interest, this topic has been specifically referred to as cardiac surgery-associated acute kidney injury (CSA-AKI). CSA-AKI could contribute to increased in-hospital mortality, 5-year mortality, 30-day readmission,
acute kidney injury 5158 systematically searched from inception to 15 March 2014, with the following keywords: sodium bicarbonate, acute kidney injury , and cardiac surgery. No limitation was enhanced. To include additional eligible studies, the reference
acute kidney injury 12782 infusion of 0.2 mmol/kg/hour over 23 hours, IVsCr criteria within the first 5 postoperative daysAKI, acute kidney injury ; BW, body weight; CKD, chronic kidney disease; CPB, cardiopulmonary bypass; CSA-AKI, cardiac surgery-associated
acute kidney injury 12914 weight; CKD, chronic kidney disease; CPB, cardiopulmonary bypass; CSA-AKI, cardiac surgery-associated acute kidney injury ; GFR, glomerular filtration rate; IV, intravenous injection; RCT, randomized controlled trial; SBIC,
acute kidney injury 13964 as percentages across all included studies.Primary outcome: incidence of cardiac surgery-associated acute kidney injury All five studies reported the outcome of CSA-AKI and all of these were involved to estimate the pooled
acute kidney injury 14660 (Figure 3).Figure 3Forest plot for the meta-analysis of the incidence of cardiac surgery-associated acute kidney injury . Five randomized controlled trials included [[2]–[6]]. CI, confidence interval; RR, relative risk;
acute kidney injury 16229 1.26)0.6280CI, confidence interval; CKD, chronic kidney disease; CSA-AKI, cardiac surgery-associated acute kidney injury ; RR, relative risk; SBIC, sodium bicarbonate.Secondary outcomesCompared with placebo, SBIC did not alter
chronic kidney disease 8541 (full-text article, large-scale trials (sample size >100), patients with pre-existing renal impairment or chronic kidney disease , elective or urgent surgery, and only elective surgery) were also conducted. Owing to the limited number
chronic kidney disease 12825 IVsCr criteria within the first 5 postoperative daysAKI, acute kidney injury; BW, body weight; CKD, chronic kidney disease ; CPB, cardiopulmonary bypass; CSA-AKI, cardiac surgery-associated acute kidney injury; GFR, glomerular
chronic kidney disease 16169 1.48)0.63777.9Elective surgery [[2],[6]]2537126/270119/2671.05 (0.87 to 1.26)0.6280CI, confidence interval; CKD, chronic kidney disease ; CSA-AKI, cardiac surgery-associated acute kidney injury; RR, relative risk; SBIC, sodium bicarbonate.Secondary

You must be authorized to submit a review.