Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease

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chronic kidney disease 3 nephrologydiseases
focal segmental glomerulosclerosis 1 nephrologydiseases
glomerulonephritis 1 nephrologydiseases

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chronic kidney disease 179 PhysiologyDual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease Radko KomersHoracio PlotkinPublication date (epub): 3/2016Publication date (ppub): 5/2016Publication
chronic kidney disease 435 3/2016AbstractInhibition of the renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in treatment of chronic kidney disease s (CKD). However, reversal of the course of CKD or at least long-term stabilization of renal function
chronic kidney disease 2210 profile.inhibition of the renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in treatment of chronic kidney disease s (CKD). Inhibitors of the RAAS (RAASis) can slow the progressive decrease in glomerular filtration rate
focal segmental glomerulosclerosis 7023 resulting in foot process effacement, a hallmark of podocytopathies ([5], [10], [47], [66]) including focal segmental glomerulosclerosis (FSGS) ([10], [17]). Podocytes are not only targets of ET-1 actions, but also a source of the peptide
glomerulonephritis 19191 initially noted in acute studies with ERAs in patients with nondiabetic CKD caused by various forms of glomerulonephritis and secondary FSGS. Infusion of BQ123 reduced proteinuria more than nifedipine ([21]), despite similar

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