Serum Magnesium after Kidney Transplantation: A Systematic Review.

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Annotation Summary

Term Occurence Count Dictionary
metabolic acidosis 3 nephrologydiseases
tacrolimus 8 nephrologydiseasesdrugs
calcium acetate 2 nephrologydiseasesdrugs
chronic kidney disease 1 nephrologydiseases
cyclosporine 6 nephrologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
calcium acetate 9701 hemodialysis patients were randomized to one group receiving oral Mg citrate (610 mg per day) and oral calcium acetate , and the other oral calcium acetate and a placebo. After 2 months, patients receiving Mg had a significant
calcium acetate 9737 to one group receiving oral Mg citrate (610 mg per day) and oral calcium acetate, and the other oral calcium acetate and a placebo. After 2 months, patients receiving Mg had a significant decrease in intima-media thickness
cyclosporine 5439 volume expansion, alcohol, hypercalcemia, nephrotoxins such as aminoglycoside antibiotics, cisplatin or cyclosporine . Urinary Mg wasting can also be due to loop of Henle or distal tubule dysfunction, after acute tubular
cyclosporine 10699 Hypomagnesemia was observed in 6.6% of patients treated with tacrolimus and in 1.5% of patients on cyclosporine [[23]]. The mechanisms leading to hypomagnesemia are not fully understood, but it has been shown that
cyclosporine 11235 Mg wasting has been shown to be similar between rats treated with sirolimus and those treated with cyclosporine or tacrolimus [[27]]. Many other factors influence Mg levels after kidney transplantation, such as post-transplantation
cyclosporine 12783 glomerular dysfunction and the development of chronic fibrotic lesions [[34]]. In mice treated with cyclosporine , Mg supplementation improved renal function and decreased kidney fibrotic lesions [[35]]. Likewise,
cyclosporine 12918 improved renal function and decreased kidney fibrotic lesions [[35]]. Likewise, Mg supplementation in cyclosporine -treated rats was associated with a reduction in tubular atrophy and interstitial fibrosis and prevented
cyclosporine 22052 the timing of supplementation and consequent drug exposure along with the use of tacrolimus versus cyclosporine can explain the smaller effect of their intervention compared with other trials [[60]]. Similar results
tacrolimus 10661 inhibitors (CNI) that induce Mg urinary waste. Hypomagnesemia was observed in 6.6% of patients treated with tacrolimus and in 1.5% of patients on cyclosporine [[23]]. The mechanisms leading to hypomagnesemia are not fully
tacrolimus 11251 been shown to be similar between rats treated with sirolimus and those treated with cyclosporine or tacrolimus [[27]]. Many other factors influence Mg levels after kidney transplantation, such as post-transplantation
tacrolimus 16516 rejection, hepatitis C, higher body mass index, higher pre-transplant glucose levels and higher trough tacrolimus levels [[51],[52],[53]], some of them being common risk factors for type-2 diabetes in the general population.
tacrolimus 18615 transplantation, 20 patients developed PTDM at 9 days post transplantation on average. Hypomagnesemia and high tacrolimus levels were significant and independent risk factors for PTDM (p = 0.01 and p < 0.001, respectively).
tacrolimus 18770 factors for PTDM (p = 0.01 and p < 0.001, respectively). No association between hypomagnesemia and tacrolimus levels was observed, suggesting that both risk factors were independent from each other [[55]]. Conversely,
tacrolimus 21809 the Mg group compared to the control group (95% CI; 1.7–21.3; p = 0.02), even after adjustment on tacrolimus concentrations. No differences were observed between groups for 2 h-AUC glucose and HOMA-IR. The authors
tacrolimus 22034 that a disparity in the timing of supplementation and consequent drug exposure along with the use of tacrolimus versus cyclosporine can explain the smaller effect of their intervention compared with other trials
tacrolimus 22244 [[60]]. Similar results were observed in another study including 52 renal transplant recipients on tacrolimus with chronic hypomagnesemia. Recipients were randomized to the Mg group (n = 26), with a similar Mg
Select Disease Character Offset Disease Term Instance
chronic kidney disease 794 6/2018Publication date (collection): 6/2018AbstractMagnesium (Mg) status has recently drawn close attention in chronic kidney disease and in kidney transplant recipients. This review aims to evaluate the body of evidence linking hypomagnesemia
metabolic acidosis 6583 some ESRD patients on high doses of diuretics, with reduced gastrointestinal uptake induced by severe metabolic acidosis or reduced albumin levels [[5]].Dialysate Mg concentration has a significant impact on Mg balance in
metabolic acidosis 11386 factors influence Mg levels after kidney transplantation, such as post-transplantation volume expansion, metabolic acidosis , insulin resistance, decreased gastro-intestinal absorption due to diarrhea, low Mg intake and medication
metabolic acidosis 14281 type-2 diabetes [[38]]. Poor dietary Mg intake, glomerular hyperfiltration, osmotic diuresis, recurrent metabolic acidosis , hypophosphataemia and hypokalemia are all potential contributing factors for hypomagnesemia in diabetic

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