Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update.

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Term Occurence Count Dictionary
nephrogenic diabetes insipidus 4 nephrologydiseases
amiloride 1 nephrologydiseasesdrugs
chlorothiazide 1 nephrologydiseasesdrugs
hydronephrosis 2 nephrologydiseases

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Select Drug Character Offset Drug Term Instance
amiloride 25708 output when associated with a very low sodium-restricted diet [[105]]. Potassium sparing agents such as amiloride might have an additive effect with thiazide diuretics via a mechanism likely involving the inhibition
chlorothiazide 26242 patients in which urine output can be reduced by 25% to 50% [[107],[108]], and the combination with Hydro chlorothiazide has an additive effect [[106],[108]]. Single-drug therapies show lower efficacy and are therefore not
Select Disease Character Offset Disease Term Instance
hydronephrosis 9734 Persistent polyuria can lead to the development of kidney megacystis, trabeculated bladder, hydroureter, and hydronephrosis [[39]].Repeated episodes of dehydration can cause mental retardation [[41],[42]], which is a serious
hydronephrosis 20204 no response to DDAVP, produced large volumes of hypotonic urine, and showed severe symptoms of both hydronephrosis and obstructive nephropathy. About 90% of mutant mice died between two and four weeks of age [[98]].Lloyd
nephrogenic diabetes insipidus 1200 cells of the collecting duct. Mutations of either AVPR2 or AQP2 result in a genetic disease known as nephrogenic diabetes insipidus , which is characterized by the lack of responsiveness of the collecting duct to the antidiuretic action
nephrogenic diabetes insipidus 1675 as the genetic or clinical tests for a prompt diagnosis of the disease in newborns. A real cure for nephrogenic diabetes insipidus (NDI) is still missing, and the main symptoms of the disease are handled with s continuous supply of
nephrogenic diabetes insipidus 7848 altered trafficking of AQP2 dramatically impair water reabsorption in the kidney. The congenital form of nephrogenic diabetes insipidus (NDI) is a rare inherited disorder, characterized by insensitivity of the distal nephron to the antidiuretic
nephrogenic diabetes insipidus 56326 for AQP2 missorting.ijms-18-02385-t001_Table 1Table 1Overview and classification of mutations causing nephrogenic diabetes insipidus (NDI) as reported by HGMD® Professional 2017.3 as of September 2017.Gene/Mutation TypeLocationDiseaseNumber

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