Stirring the Pot: Can Dietary Modification Alleviate the Burden of CKD?

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Term Occurence Count Dictionary
chronic kidney disease 7 nephrologydiseases
metabolic acidosis 5 nephrologydiseases
paricalcitol 5 nephrologydiseasesdrugs
renal osteodystrophy 1 nephrologydiseases

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Select Drug Character Offset Drug Term Instance
paricalcitol 24181 population.6.2. Vitamin D Supplementation and Parathyroid HormoneNewer vitamin D analogues, such as paricalcitol , play an important role in CKD as they appear to have better suppression of parathyroid hormone and
paricalcitol 24411 a calcaemic effect compared to other vitamin D sterol forms [[85]]. Several studies have shown that paricalcitol supplementation in CKD patients was associated with a decrease in PTH levels [[86],[87],[88]]. The study
paricalcitol 24957 effective in lowering parathyroid hormone levels, some concern has been raised over the potential risk that paricalcitol may exacerbate vascular calcification [[91]].6.3. Vitamin D Supplementation and ProteinuriaReduction
paricalcitol 25293 and mortality [[92]]. Several studies have shown that oral supplementation with the vitamin D analog paricalcitol is effective at reducing proteinuria in stage 2–4 CKD patients [[87],[88],[89],[93]]. Furthermore,
paricalcitol 25412 effective at reducing proteinuria in stage 2–4 CKD patients [[87],[88],[89],[93]]. Furthermore, oral paricalcitol therapy achieves these reductions in proteinuria without an increase in adverse events [[77]]. A meta-analysis
Select Disease Character Offset Disease Term Instance
chronic kidney disease 624 3/2017Publication date (collection): 3/2017AbstractDiet is one of the largest modifiable risk factors for chronic kidney disease (CKD)-related death and disability. CKD is largely a progressive disease; however, it is increasingly
chronic kidney disease 779 disability. CKD is largely a progressive disease; however, it is increasingly appreciated that hallmarks of chronic kidney disease such as albuminuria can regress over time. The factors driving albuminuria resolution remain elusive.
chronic kidney disease 22661 Vitamin D deficiency and secondary hyperparathyroidism are recognised to be complications associated with chronic kidney disease [[61]].6.1. Low Vitamin D, CKD and Association with MortalityCardiovascular disease is a significant
chronic kidney disease 27877 lack of convincing evidence for vitamin D supplementation across a range of health outcomes, including chronic kidney disease [[100]]. Current Australian guidelines recommend vitamin D supplementation in those with early chronic
chronic kidney disease 27995 disease [[100]]. Current Australian guidelines recommend vitamin D supplementation in those with early chronic kidney disease and secondary hyperparathyroidism though admits evidence does not exist to support that this leads to
chronic kidney disease 56868 may not. There have been limited studies that have investigated fructose consumption in patients with chronic kidney disease [[209]]. In a pilot study by Brymora et al., patients with stage 2 and 3 CKD followed a low-fructose
chronic kidney disease 66473 establish the role of these dietary factors in CKD patients.Figure 1Mechanisms of dietary factors impact on chronic kidney disease . n-3 PUFAs = Omega 3 Polyunsaturated Fatty Acids. CRP = C-Reactive Protein. MCP-1 = Monocyte Chemoattractant
metabolic acidosis 5447 [[15],[16]]. Other factors that occur due to excess protein metabolism, such as increased GFR [[17]], metabolic acidosis [[11]] and oxidative stress [[18]], are also thought to contribute to kidney damage associated with
metabolic acidosis 10780 mortality (discussed below) [[32]]. A very low protein vegetarian diet has also been noted to reduce metabolic acidosis in a cohort of CKD patients [[38]]. Fruit and vegetables are sources of dietary alkali and interventions
metabolic acidosis 11045 populations have been shown to increase plasma CO2 levels [[39],[40]], indicative of amelioration of metabolic acidosis . Taken together, the evidence suggests that increasing the proportion of plant-based protein intake
metabolic acidosis 21231 early CKD. In a group of stage 4 CKD patients, selected to be at low risk for hyperkalaemia, treating metabolic acidosis with base-producing vegetables was effective in improving metabolic acidosis and reducing kidney injury
metabolic acidosis 21308 hyperkalaemia, treating metabolic acidosis with base-producing vegetables was effective in improving metabolic acidosis and reducing kidney injury [[40]]. Larger long-term trials in CKD patients investigating plant-based
renal osteodystrophy 22526 hyperparathyroidism can lead to alterations in bone turnover and metabolism and the development of renal osteodystrophy [[78]]. Vitamin D deficiency and secondary hyperparathyroidism are recognised to be complications associated

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