Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis

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Term Occurence Count Dictionary
focal segmental glomerulosclerosis 1 nephrologydiseases
glomerulonephritis 21 nephrologydiseases
interstitial nephritis 2 nephrologydiseases
lupus nephritis 1 nephrologydiseases
membranous glomerulonephritis 1 nephrologydiseases
acute kidney injury 1 nephrologydiseases
chronic kidney disease 1 nephrologydiseases
cyclosporine 2 nephrologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
cyclosporine 11568 the renal injury by thrombotic microangiopathy (TMA)/hemolytic uremic syndrome (HUS) [[29],[30]], and cyclosporine nephrotoxicity [[31]]. In an experimental TMA model, subcutanous administration of VEGF121 resulted
cyclosporine 12221 necrosis, and severe lesions could be prevented by VEGF administration [[30]]. In a rat model of chronic cyclosporine nephrotoxicity, VEGF, as well as VEGFR-1 and VEGFR-2 expression increased as early as seven days after
Select Disease Character Offset Disease Term Instance
acute kidney injury 24240 in the early phase, but is, in turn, a critical mediator of renal fibrogenesis in the later phase of acute kidney injury (AKI) [[66]]. This suggests that EGFR exerts dual roles in the course of severe AKI, and that sustained
chronic kidney disease 1685 therapeutic approach for renal fibrosis.1. IntroductionIn the general population, the prevalence of chronic kidney disease (CKD) is more than 10%. Many patients with CKD will eventually progress to end-stage of renal disease
focal segmental glomerulosclerosis 14398 glomerulonephritis, membranoproliferative glomerulonephritis, mesangioproliferative glomerulonephritis, focal segmental glomerulosclerosis (FSGS), and IgA nephropathy [[22]]. Depressed VEGF synthesis induced by podocyte injury may contribute
glomerulonephritis 7977 injury and reduces inflammatory responses [[16]]. In addition, in rat anti-Thy 1.1 mesangioproliferative glomerulonephritis , glomerular and tubulointerstitial scarring, as well as the subsequent development of renal failure,
glomerulonephritis 8516 that imatinib, which can inhibit selective RTKS, including PDGFRα, ameliorated mesangioproliferative glomerulonephritis in rats, glomerular and tubulointerstitial lesions in experimental diabetic nephropathy (DN). Furthermore,
glomerulonephritis 13820 demonstrates that administration of a selective and potent inhibitor of VEGF to rat with crescentic glomerulonephritis , one type of VEGFR, soluble Fms-like tyrosine kinase receptor 1 (sFlt-1) accelerates proteinuria with
glomerulonephritis 14204 VEGFR are involved in the regulation of podocyte function, they play key roles in the pathogenesis of glomerulonephritis , which is demonstrated in minimal change nephropathy (MCD), membranous glomerulonephritis, membranoproliferative
glomerulonephritis 14294 pathogenesis of glomerulonephritis, which is demonstrated in minimal change nephropathy (MCD), membranous glomerulonephritis , membranoproliferative glomerulonephritis, mesangioproliferative glomerulonephritis, focal segmental
glomerulonephritis 14336 demonstrated in minimal change nephropathy (MCD), membranous glomerulonephritis, membranoproliferative glomerulonephritis , mesangioproliferative glomerulonephritis, focal segmental glomerulosclerosis (FSGS), and IgA nephropathy
glomerulonephritis 14378 (MCD), membranous glomerulonephritis, membranoproliferative glomerulonephritis, mesangioproliferative glomerulonephritis , focal segmental glomerulosclerosis (FSGS), and IgA nephropathy [[22]]. Depressed VEGF synthesis induced
glomerulonephritis 17975 fibroblasts [[49]]. In experimental animal models of membranous nephropathy, mesangioproliferative glomerulonephritis , IgA glomerulonephritis, CAN, and FGF-2/FGFR1 expression increased several times in cell proliferation
glomerulonephritis 17999 experimental animal models of membranous nephropathy, mesangioproliferative glomerulonephritis, IgA glomerulonephritis , CAN, and FGF-2/FGFR1 expression increased several times in cell proliferation regions, which are closely
glomerulonephritis 22026 fibrosis in an experimental hypertension model [[61]]. In both mice and humans with rapidly progressive glomerulonephritis (RPGN), Bollée et al. [[62]] found de novo induction of HB-EGF in intrinsic glomerular epithelial cells
glomerulonephritis 30990 with MCD [[89]]. IGFBP-1 levels are also elevated in the kidneys in a mouse model of experimental IgA glomerulonephritis and in serum of patients with IgA glomerulonephritis. This correlates with mesangial cell proliferation
glomerulonephritis 31043 the kidneys in a mouse model of experimental IgA glomerulonephritis and in serum of patients with IgA glomerulonephritis . This correlates with mesangial cell proliferation and other markers of kidney damage [[90]]. IGFs can
glomerulonephritis 33798 antibodies against the glomerular basement membrane, DDR1 was involved in the injury of crescentic glomerulonephritis . Imatinib and nilotinib, the inhibitors for multiple RTKs, including DDR1, can regulate the immune response
glomerulonephritis 34891 normal kidney. However, its expression can be upregulated in several murine models of CKD including: glomerulonephritis induced by Thy1.1 antibody, nephrotoxic nephritis (NS), STZ-induced DN and a podocyte ablation model
glomerulonephritis 35528 the presence of high glucose (HG) [[107]]. Patients with inflammatory kidney disease [[103]] and IgA glomerulonephritis [[108]] had elevated plasma Gas6/Axl levels. In a murine sub-total nephrectomy and high phosphate diet
glomerulonephritis 37715 also been shown to attenuate pathological changes in different models of CKD, including experimental glomerulonephritis [[112],[113]], DN [[114]], LN [[115]], and CAN [[116]]. In addition, AG1296, a specific TKI for FGFR,
glomerulonephritis 41558 gefitinib, including minimal change, nephritic syndrome [[130]], tubulointerstitial nephritis and IgA glomerulonephritis [[131],[132]]. However, the renal complications may be secondary to the original tumors. Therefore,
glomerulonephritis 46419 EGFRAttenuates glomerular and vascular injury and reduces inflammatory responses[[22]]Rat chronic anti-Thy 1.1 glomerulonephritis B-specific oligonucleotideaptamerPDGFRDecreases proteinuria and improves renal function; Inhibits glomerulosclerosis
glomerulonephritis 46616 function; Inhibits glomerulosclerosis and tubulointerstitial fibrosis[[23]]Rat chronic anti-Thy 1.1 glomerulonephritis Neutralizing anti-PDGF-D IgGPDGFRDecreases proteinuria and improves renal function; Inhibits glomerulosclerosis
glomerulonephritis 46816 function; Inhibits glomerulosclerosis and tubulointerstitial fibrosis and EMT[[24]]Rat acute anti–Thy 1.1 glomerulonephritis TrapidilPDGFRInhibits mesangial cells proliferation and matrix accumulation[[25]]Rat ischemia/reperfusion
glomerulonephritis 47515 damage[[16]]Rat unilateral ureter obstructionAG 1295PDGFRInhibits tubulointerstitial fibrosis[[27]]Rat crescentic glomerulonephritis sFlt-1VEGFRAccelerates proteinuria with massive ascites, glomerulosclerosis, and interstitial fibrosis[[51]]Rat
interstitial nephritis 19850 expression was observed in the fibrotic areas of renal biopsy specimens from patients with LN and acute interstitial nephritis . This supports the possibility that FGF-1 may contribute to infiltrating inflammatory cells and associated
interstitial nephritis 41527 patient after treatment with gefitinib, including minimal change, nephritic syndrome [[130]], tubulo interstitial nephritis and IgA glomerulonephritis [[131],[132]]. However, the renal complications may be secondary to the original
lupus nephritis 8771 glomerular hypercellularity, tubulointerstitial fibrosis, activation of myofibroblasts in mice with lupus nephritis (LN) and prevented chronic allograft nephropathy (CAN) [[12]]. Another TKI for PDGFR, AG 1295, can also
membranous glomerulonephritis 14283 the pathogenesis of glomerulonephritis, which is demonstrated in minimal change nephropathy (MCD), membranous glomerulonephritis , membranoproliferative glomerulonephritis, mesangioproliferative glomerulonephritis, focal segmental

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