Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies.

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chronic kidney disease 52 Title: Arthritis Research & TherapyGout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studiesMatthew J RoughleyJohn BelcherChristian D
chronic kidney disease 344 (pmc-release): 4/2015Publication date (ppub): /2015AbstractIntroductionTo determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident
chronic kidney disease 467 and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis.MethodsSystematic review and meta-analysis of epidemiological studies. Data sources;
chronic kidney disease 812 Eligibility criteria: cohort, case–control or cross-sectional studies which examined the occurrence of chronic kidney disease or nephrolithiasis amongst adults with gout (with or without a non-gout comparator group) in primary
chronic kidney disease 1120 performed using a random-effects model.ResultsSeventeen studies were included in the meta-analysis ( chronic kidney disease n = 7, nephrolithiasis n = 8, both n = 2). Pooled prevalence estimates of chronic kidney
chronic kidney disease 1229 kidney disease n = 7, nephrolithiasis n = 8, both n = 2). Pooled prevalence estimates of chronic kidney disease stage ≥3 and self-reported lifetime nephrolithiasis in people with gout were 24% (95% confidence interval
chronic kidney disease 1444 confidence interval 19% to 28%) and 14% (95% CI 12% to 17%) respectively. Gout was associated with both chronic kidney disease (pooled adjusted odds ratio 2.41, 95% confidence interval 1.86 to 3.11) and self-reported lifetime nephrolithiasis
chronic kidney disease 1747 nephrolithiasis are commonly found amongst patients with gout. Gout is independently associated with both chronic kidney disease and nephrolithiasis. Patients with gout should be actively screened for chronic kidney disease and its
chronic kidney disease 1842 both chronic kidney disease and nephrolithiasis. Patients with gout should be actively screened for chronic kidney disease and its consequences.IntroductionGout is the most prevalent inflammatory arthritis, affecting 2.4% of
chronic kidney disease 10333 Reasons for exclusion are shown in Figure 1.Figure 1Selection of studies included in the review. CKD, chronic kidney disease .Study characteristicsTwelve studies examined CKD [[22]-[33]], 15 studies examined nephrolithiasis [[13],[34]-[47]],
chronic kidney disease 17209 (self-reported lifetime prevalence)ARA, American Rheumatism Association; CC, case–control study; CKD, chronic kidney disease ; CS, cross-sectional; ESRD, end-stage renal disease; GP, general practitioner; HR, hazard ratio; ICD,
chronic kidney disease 21270 not reported by other studies, thus precluding meta-analysis [[26],[31],[37]].Prevalence and risk of chronic kidney disease in goutSix studies provided suitable data to allow the pooled prevalence of CKD stage ≥3 in people
chronic kidney disease 22165 (I2 = 82.5%, P = 0.003).Figure 2Forest plot of individual and pooled (random effects) prevalences of chronic kidney disease stage ≥3 in gout. CI, confidence interval.Comparing patients with gout to those without gout, the
chronic kidney disease 23012 plot of individual and pooled (random effects) unadjusted and adjusted odds ratios between gout and chronic kidney disease stage ≥3. CI, confidence interval.One study reported prevalence of ESRD requiring RRT in gout (0.6%)

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