Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome.

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Term Occurence Count Dictionary
nephrosclerosis 1 nephrologydiseases
nephrotic syndrome 1 nephrologydiseases
chronic kidney disease 10 nephrologydiseases
focal segmental glomerulosclerosis 1 nephrologydiseases
kidney failure 2 nephrologydiseases
lupus nephritis 2 nephrologydiseases

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chronic kidney disease 893 olarysz@rmed.plPublication date (epub): 8/2017Publication date (collection): 8/2017AbstractIn its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent. Significant reduction of the kidney function is the first obvious sign
chronic kidney disease 2438 specificity as well as the reduction of analysis costs are required.1. IntroductionCharacteristic features of chronic kidney disease (CKD) involve progressive destruction of the renal parenchyma and the loss of functional nephrons [[1],[2]].
chronic kidney disease 2867 development of renal lesions and lead to end-stage renal disease (ESRD) [[4],[5]]. The development of chronic kidney disease involves the separation of podocytes from basal membrane and their loss with urine, therefore the determination
chronic kidney disease 3174 barrier may be helpful in the diagnosis of renal diseases [[6]].The loss of function in the course of chronic kidney disease is also associated with interstitial fibrosis and inflammation. Early diagnosis of this disease is important
chronic kidney disease 6782 urine sample. Urinalysis can be used to detect a numerous kidney and urinary tract disorders, such as chronic kidney disease , bladder infections and kidney stones [[18]].Apart from traditional methods, saliva and exhaled breath
chronic kidney disease 7085 saliva urea nitrogen (SUN) dipstick has been suggested as a potential screening tool for acute and chronic kidney disease [[19],[20],[21]]. Raimann et al. [[20]] demonstrated that SUN strips have a higher screening sensitivity
chronic kidney disease 7227 Raimann et al. [[20]] demonstrated that SUN strips have a higher screening sensitivity for detecting chronic kidney disease when applied alone but a better diagnostic specificity when used in combination with patient-reported
chronic kidney disease 14049 concentrations of uromodulin are found in persons with interstitial fibrosis or tubular atrophy in the course of chronic kidney disease [[55]]. Uromodulin has been suggested as a promising biomarker for the number of intact nephrons, which
chronic kidney disease 17003 to detectable changes in eGFR [[60],[61],[62]]. It was also suggested to be potential biomarker of chronic kidney disease due to tubulointerstitial damage [[63]]. Increased concentration of urinary KIM-1 may indicate the proximal
chronic kidney disease 24018 confirmed in further studies.According to studies, circulating miRNAs usually tend to decline during severe chronic kidney disease and/or dialysis [[86]]. Circulating miR-21 has been shown to be associated with fibrosis score and to
focal segmental glomerulosclerosis 30338 pathology [[91]]. Siwy et al. [[105]] in their study identified 287 disease-specific biomarkers for focal segmental glomerulosclerosis (FSGS), 291 for minimal change disease (MCD), 311 for membranous nephropathy (MN), 172 for lupus nephritis
kidney failure 3414 the prevention of CKD complications. Moreover, it is needed for the hampering of the progression to kidney failure and preventing the occurrence of cardiovascular events [[7]].Currently, the diagnosis of CKD is made
kidney failure 4038 or irreversibly damaged. This may lead to the lack of detection of early stages of acute or chronic kidney failure and therefore to the delayed application of detailed diagnostics and the implementation of therapeutic
lupus nephritis 30464 glomerulosclerosis (FSGS), 291 for minimal change disease (MCD), 311 for membranous nephropathy (MN), 172 for lupus nephritis (LN), 509 for renal vasculitis, and 116 for IgA nephropathy (IgAN),as well as 619 diabetic nephropathy
lupus nephritis 32155 up-regulated in FSGS which is in agreement with other studies [[108],[109]]. The differentiation between lupus nephritis and other types of CKD can be made on the basis of the calcium and zinc-binding protein S100-22 fragment,
nephrosclerosis 30587 509 for renal vasculitis, and 116 for IgA nephropathy (IgAN),as well as 619 diabetic nephropathy and nephrosclerosis (DN&N)-specific biomarkers. DN&N was associated with a reduction in haemoglobin level in comparison
nephrotic syndrome 27049 CKD patients than in healthy persons. The presence of miR-181a was earlier described in patients with nephrotic syndrome and those who underwent kidney transplantation. miR-181a has been suggested to be a potential biomarker

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