Protein Nutrition and Malnutrition in CKD and ESRD.

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Annotation Summary

Term Occurence Count Dictionary
chronic kidney disease 1 nephrologydiseases
kidney failure 4 nephrologydiseases
lanthanum carbonate 1 nephrologydiseasesdrugs
metabolic acidosis 7 nephrologydiseases
nephrotic syndrome 1 nephrologydiseases
renal tubular acidosis 1 nephrologydiseases
sodium bicarbonate 2 nephrologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
lanthanum carbonate 25025 target range (3.5 to <5.5 mg/dL) by providing high-protein meals during hemodialysis combined with lanthanum carbonate administration [[144]]. It should be noted, however, the occurrence of intradialytic hypotension associated
sodium bicarbonate 4087 (mmol/kg/day), referred to as NEAP (net endogenous acid production). These are rapidly buffered by sodium bicarbonate (NaHCO3) to form sodium salts. During this process, bicarbonate is consumed, which needs to be regenerated,
sodium bicarbonate 25710 reduced CKD progression.5.2. Correcting Metabolic AcidosisMetabolic acidosis should be corrected with sodium bicarbonate (NaHCO3). NaHCO3 corrects acidosis in children with renal tubular acidosis and stimulates growth in
Select Disease Character Offset Disease Term Instance
chronic kidney disease 487 (collection): 3/2017AbstractElevated protein catabolism and protein malnutrition are common in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). The underlying etiology includes, but is not limited to, metabolic
kidney failure 7033 feature of CKD and ESRD [[29],[30]]. It is related to a multitude of abnormalities in the setting of kidney failure . As illustrated in Figure 2, altered gut microbiome profile, evidenced in even the early stages of CKD
kidney failure 10153 muscle protein degradative cascades [[67]]. TWEAK, as well as IL-6, is highly expressed in patients with kidney failure , and both are shown to be associated with reduced muscle strength in dialysis patients [[68]]. Myostatin,
kidney failure 15037 [[97]].Given the tissue resistance to GH and IGF-1, it should come as no surprise that children with kidney failure exhibit growth retardation. In adults, such hormone resistance manifests as an accelerated protein catabolism
kidney failure 25865 in children with renal tubular acidosis and stimulates growth in premature infants and children with kidney failure . NaHCO3 and potassium bicarbonate improve nitrogen balance in elderly with even mild metabolic acidosis
metabolic acidosis 609 (CKD) and end-stage renal disease (ESRD). The underlying etiology includes, but is not limited to, metabolic acidosis intestinal dysbiosis; systemic inflammation with activation of complements, endothelin-1 and renin-angiotensin-aldosterone
metabolic acidosis 1981 malnutrition [[3],[4]]. Suboptimal nutritional status has been related to multiple alterations including metabolic acidosis , bowel flora alteration and hormonal dysregulation, all of which could promote kidney disease progression
metabolic acidosis 4561 generation [[7]]. In patients with reduced kidney function, nonvolatile acids can accumulate causing metabolic acidosis .3. Metabolic and Regulatory Derangements in CKD and ESRDAs shown in Figure 1, kidney dysfunction is
metabolic acidosis 25965 kidney failure. NaHCO3 and potassium bicarbonate improve nitrogen balance in elderly with even mild metabolic acidosis [[146],[147]]. Based on available evidence and while awaiting results from several larger sized randomized
metabolic acidosis 26580 [[152],[153],[154]].In dialysis patients (both hemodialysis and peritoneal dialysis), correction of metabolic acidosis reduces protein degradation and negative nitrogen balance [[25],[155],[156],[157],[158]], and significantly
metabolic acidosis 33941 protective strategies in parallel with other measures.Figure 1Interconnection of CKD progression with metabolic acidosis , inflammation, hormonal resistance and protein catabolism. (A) Kidney dysfunction limits proton (H+)
metabolic acidosis 34096 and protein catabolism. (A) Kidney dysfunction limits proton (H+) excretion, resulting in a systemic metabolic acidosis . The acidosis causes activation of complement systems, renin angiotensin aldosterone systems and endothelin-1.
nephrotic syndrome 14861 demonstrated in uremic rodents [[96]]. Urinary loss of IGF and IGFBP can also be significant in patients with nephrotic syndrome and contributes to the inadequate IGF-related functions [[97]].Given the tissue resistance to GH and
renal tubular acidosis 25781 acidosis should be corrected with sodium bicarbonate (NaHCO3). NaHCO3 corrects acidosis in children with renal tubular acidosis and stimulates growth in premature infants and children with kidney failure. NaHCO3 and potassium bicarbonate

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