Pathologic manifestations of levamisole-adulterated cocaine exposure

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Term Occurence Count Dictionary
prednisone 1 nephrologydiseasesdrugs
rituximab 1 nephrologydiseasesdrugs
acute kidney injury 1 nephrologydiseases
glomerulonephritis 15 nephrologydiseases
nephrotic syndrome 2 nephrologydiseases

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Select Drug Character Offset Drug Term Instance
prednisone 12914 and levamisole on mass spectrometry. He displayed both hematuria and proteinuria, was treated with prednisone , and left against medical advice. Seven months later, he presented after repeat cocaine use with acute
rituximab 17116 appear to correlate with disease relapse [[40],[41]]. Furthermore, treatment with B-cell depleting rituximab successfully treats symptoms of ANCA-associated disease [[30]]. Additionally, transplacental MPO-ANCA
Select Disease Character Offset Disease Term Instance
acute kidney injury 12491 cocaine, eight out of thirty patients were reported to have proteinuria or hematuria, and two developed acute kidney injury [[23]]. One patient underwent renal biopsy showing focal necrotizing and crescentic pauci-immune glomerulonephritis.
glomerulonephritis 1233 deep dermal vessels. Renal injury most typically manifests as crescentic and necrotizing pauci-immune glomerulonephritis . In this review, the manifestations of levamisole-adulterated cocaine-induced vasculitis are discussed
glomerulonephritis 2087 polyangiitis (GPA), which is characterized by skin lesions, nasal and palate destruction, pauci-immune glomerulonephritis with crescents and/or necrotizing lesions, and positive laboratory test for cytoplasmic antineutrophil
glomerulonephritis 3294 neutropenia/agranulocytosis, and purpuric lesions involving the face, especially the ear lobes, with varying frequencies of glomerulonephritis and lung hemorrhage. The increased prevalence appears to be correlated with the escalating abuse of
glomerulonephritis 12608 injury [[23]]. One patient underwent renal biopsy showing focal necrotizing and crescentic pauci-immune glomerulonephritis . In another case report, a 45-year-old man presented with characteristic necrotic skin lesions and an
glomerulonephritis 13129 on chronic renal insufficiency and a renal biopsy displaying necrotizing and crescentic pauci-immune glomerulonephritis [[34]].In a review of an inner city hospital’s pauci-immune glomerulonephritis cases over a two-year
glomerulonephritis 13210 crescentic pauci-immune glomerulonephritis [[34]].In a review of an inner city hospital’s pauci-immune glomerulonephritis cases over a two-year period, four patients were identified with disease who had exposure to cocaine,
glomerulonephritis 14438 complex deposition. Thus, these features were classified as crescentic and necrotizing pauci-immune glomerulonephritis .Figure 2Kidney biopsy from a patient with exposure to levamisole-adulterated cocaine.A) Necrotizing
glomerulonephritis 14951 400X). Note that the glomerular tuft is otherwise relatively normal, as is often seen in pauci-immune glomerulonephritis .These reports suggest a role for levamisole-adulterated cocaine in the induction of pauci-immune glomerulonephritis.
glomerulonephritis 15067 glomerulonephritis.These reports suggest a role for levamisole-adulterated cocaine in the induction of pauci-immune glomerulonephritis . In the kidney, pure cocaine use without an autoimmune syndrome most commonly leads to severe intimal
glomerulonephritis 15466 [[36]-[38]]. Cocaine-induced GPA with a positive c-ANCA serology can be associated with a pauci-immune glomerulonephritis [[2],[4],[3]]. Interestingly, glomerulonephritis is not a reported complication of levamisole-use alone,
glomerulonephritis 15515 c-ANCA serology can be associated with a pauci-immune glomerulonephritis [[2],[4],[3]]. Interestingly, glomerulonephritis is not a reported complication of levamisole-use alone, and this pathology may represent a synergistic
glomerulonephritis 15998 hemorrhage, requiring intubation, was reported in one patient who also had concurrent pauci-immune glomerulonephritis [[35]]. Three out of thirty patients with cocaine exposure and high p-ANCA antibodies developed pulmonary
glomerulonephritis 16661 cocaine-induced pathologyThe mechanism whereby levamisole-adulterated cocaine leads to vasculitis, glomerulonephritis , and agranulocytosis is unclear, but several theories have been proposed. As with other drug-induced
glomerulonephritis 17383 a neonate, which resolved shortly after birth [[42],[43]]. Animal models also exhibit pauci-immune glomerulonephritis and small vessel vasculitis after development of antibodies to MPO. The proposed mechanism supports
glomerulonephritis 20147 several case reports of both renal and lung disease that is most commonly expressed as pauci-immune glomerulonephritis and pulmonary hemorrhage, respectively. The mechanism of disease is still under investigation but hinges
nephrotic syndrome 3975 of conditions including malignancy, autoimmune disorders such as rheumatoid arthritis, and pediatric nephrotic syndrome [[10]-[12]]. It was removed from the United States market for human use in 1999 due to significant side
nephrotic syndrome 11140 These findings are similar to reports from chronic levamisole use in pediatric patients treated for nephrotic syndrome ; in one case series, 5 of 160 children developed purpura on at least the ears with biopsies revealing

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