Neuropsychiatric lupus: a mosaic of clinical presentations

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Term Occurence Count Dictionary
autoimmune disease 3 rheumatologydiseases
methylprednisolone 2 rheumatologydiseasesdrugs
neuritis 1 rheumatologydiseases
rituximab 3 rheumatologydiseasesdrugs
systemic lupus erythematosus 3 rheumatologydiseases
vasculitis 4 rheumatologydiseases
azathioprine 1 rheumatologydiseasesdrugs
mycophenolate mofetil 1 rheumatologydiseasesdrugs
prednisolone 2 rheumatologydiseasesdrugs
prednisone 5 rheumatologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
azathioprine 31781 that was treated with prednisone and plaquenil only [[86]]. Several reports describe successful use of azathioprine and mycophenolate mofetil as second line therapy [[87]] and for ‘maintenance therapy’ in order to
methylprednisolone 31086 immunosuppressant for severe NPSLE. In a controlled clinical trial [[85]], the addition of IV CYC to methylprednisolone was superior to therapy with methylprednisolone pulses alone for 32 patients with acute severe NPSLE
methylprednisolone 31134 controlled clinical trial [[85]], the addition of IV CYC to methylprednisolone was superior to therapy with methylprednisolone pulses alone for 32 patients with acute severe NPSLE (refractory seizures, cranial or peripheral neuropathy,
mycophenolate mofetil 31798 with prednisone and plaquenil only [[86]]. Several reports describe successful use of azathioprine and mycophenolate mofetil as second line therapy [[87]] and for ‘maintenance therapy’ in order to avoid prolonged exposure
prednisolone 31092 immunosuppressant for severe NPSLE. In a controlled clinical trial [[85]], the addition of IV CYC to methyl prednisolone was superior to therapy with methylprednisolone pulses alone for 32 patients with acute severe NPSLE
prednisolone 31140 clinical trial [[85]], the addition of IV CYC to methylprednisolone was superior to therapy with methyl prednisolone pulses alone for 32 patients with acute severe NPSLE (refractory seizures, cranial or peripheral neuropathy,
prednisone 18844 study concluded that depression in SLE is linked to several factors of which the usage of high dose prednisone (20 mg or higher) was found to be the most significant independent factor, while global disease activity
prednisone 19317 adverse events of therapy rather than with disease activity and may encourage clinicians to reduce prednisone doses or avoid its use [[59]]. An association of depression and specific antibodies directed at ribosomal-P,
prednisone 30460 doses of GC (for example, IV 1 g solomedrol/day for 3 to 5 days) followed by oral therapy (for example, prednisone 1 mg/kg/day) have been extensively used. Although emotional instability, mood swings (for example, depression),
prednisone 31360 neuropathy, optic neuritis, transverse myelitis, brainstem disease, and coma). All patients were treated with prednisone between pulses. Due to the effects of CYC, ovarian or sperm preservation should be considered. In another
prednisone 31700 had a statistically significant improvement when compared to the control group that was treated with prednisone and plaquenil only [[86]]. Several reports describe successful use of azathioprine and mycophenolate
rituximab 32128 particularly NPSLE which is considered to be induced by autoantibodies, therapy with anti-B cell therapy ( rituximab ), plasma exchange, or intravenous immunoglobulins (IVIG) may be considered.Anti-B cell therapiesB-lymphocytes
rituximab 32494 affect several B cell populations, were suggested for refractory disease. In a recent systematic review, rituximab was beneficial in 73 to 100% of 38 patients with refractory NPSLE; however, relapse rates were high
rituximab 32650 with refractory NPSLE; however, relapse rates were high [[88]], suggesting that repeated therapy with rituximab may be warranted. The selection and survival of B cells are controlled by a variety of signals, including
Select Disease Character Offset Disease Term Instance
autoimmune disease 12049 models can be differentiated into genetically designed strains that develop a spontaneous lupus-like autoimmune disease or those induced by adjuvant or other methods in naïve mice. Genetically prone strains are characterized
autoimmune disease 20024 corticosteroid-induced psychosis, and its prevalence in SLE was not found to be higher than in other autoimmune disease s [[64]].Acute confusional state is a diffuse neurological dysfunction that manifests as a fluctuating
autoimmune disease 22346 overlap the neuropsychiatric manifestations of Sjögren’s syndrome and aPL syndrome as well as other autoimmune disease s. Autoantibodies are central for the diagnosis of SLE; however, note that the prevalence of anti-nuclear
neuritis 31268 for 32 patients with acute severe NPSLE (refractory seizures, cranial or peripheral neuropathy, optic neuritis , transverse myelitis, brainstem disease, and coma). All patients were treated with prednisone between
systemic lupus erythematosus 335 3/2015Publication date (collection): /2015AbstractNeuropsychiatric symptoms affect nearly half of the patients with systemic lupus erythematosus ; however, the effect on disease severity, quality of life, and prognosis is tremendous. Symptoms of
systemic lupus erythematosus 481 effect on disease severity, quality of life, and prognosis is tremendous. Symptoms of neuropsychiatric systemic lupus erythematosus may range from mild diffuse ones, to acute life threatening events. Although the underlying mechanisms
systemic lupus erythematosus 976 and the new regarding epidemiology, pathophysiology, diagnosis, and management of neuropsychiatric systemic lupus erythematosus . The possible link between neuropsychiatric symptoms and specific mechanisms may help to facilitate
vasculitis 5236 designing the figure above.VasculopathyWhile only a minority of NPSLE patients have evidence of frank vasculitis on imaging or histopathology, a small vessel thrombotic-vasculopathy has been the predominant histopathological
vasculitis 5878 complement activation, cardiac emboli caused by Libman-Zachs endocarditis, and other valvular abnormalities, vasculitis , or accelerated atherosclerosis.AutoantibodiesThe fact that numerous autoantibodies are detected in
vasculitis 23300 fluidCSF analysis in NPSLE patients may be innocent, and thus non-contributory. In some cases, such as vasculitis , aseptic meningitis, and transverse myelitis, it may have a high yield in diagnosis. Several reports
vasculitis 29911 symptoms are similar to those utilized for other major organ involvement in SLE or for non-SLE CNS vasculitis . These include non-specific immunosuppression, specific immune modulation mainly targeted at the humoral

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