Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren's Syndrome

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Term Occurence Count Dictionary
arthritis 7 rheumatologydiseases
cyclosporine 1 rheumatologydiseasesdrugs
hydroxychloroquine 1 rheumatologydiseasesdrugs
mixed connective tissue disease 1 rheumatologydiseases
myositis 2 rheumatologydiseases
rituximab 1 rheumatologydiseasesdrugs
autoimmune disease 6 rheumatologydiseases
chloroquine 1 rheumatologydiseasesdrugs
connective tissue disease 1 rheumatologydiseases
dermatomyositis 1 rheumatologydiseases
rheumatoid arthritis 1 rheumatologydiseases
systemic lupus erythematosus 1 rheumatologydiseases

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Select Drug Character Offset Drug Term Instance
chloroquine 12567 expressions of these molecules were reduced in TGP-treated mice and in mice treated with both TGP with hydroxy chloroquine . Those results suggested that the administration of TGP has the potential to improve the Th1/Th2 cytokine
cyclosporine 11263 murine model that showed FasL expression in lacrimal glands, an effect of an immunosuppressive agent, cyclosporine A (CyA) was demonstrated [[53]]. In association with decreases of apoptosis and FasL in infiltrating
hydroxychloroquine 12560 expressions of these molecules were reduced in TGP-treated mice and in mice treated with both TGP with hydroxychloroquine . Those results suggested that the administration of TGP has the potential to improve the Th1/Th2 cytokine
rituximab 2550 concert with T cells that respond to autoantigens, T or B cell-targeting therapies including abatacept, rituximab , and belimumab are possible beneficial biologics for the treatment for SS [[6],[7],[8],[9]]. With regard
Select Disease Character Offset Disease Term Instance
arthritis 21158 Abdollahi-Roodsaz et al. reported that IL-1 receptor antagonist (IL-1rn−/−) knockout mice showed severe arthritis with reduced Tregs function and an up-regulation of IFN-γ production, whereas IL-1rn−/−Tlr4−/−
arthritis 21308 up-regulation of IFN-γ production, whereas IL-1rn−/−Tlr4−/− mice showed a suppression of severe arthritis with reduced numbers of Th17 cells [[84]]. In addition, the knockout of TLR9 resulted in no progression
arthritis 21425 reduced numbers of Th17 cells [[84]]. In addition, the knockout of TLR9 resulted in no progression of arthritis , suggesting that these three TLRs (i.e., TLR2, TLR4, and TLR9) have different relationships with the
arthritis 21549 that these three TLRs (i.e., TLR2, TLR4, and TLR9) have different relationships with the induction of arthritis and IL-17 production. Abdollahi-Roodsaz et al. also reported that TLR2 deficiency augmented the severity
arthritis 21678 production. Abdollahi-Roodsaz et al. also reported that TLR2 deficiency augmented the severity of rheumatoid arthritis (RA)-like arthritis with inflammatory joint and bone erosion by modulating the Fcγ receptor of macrophages,
arthritis 21698 et al. also reported that TLR2 deficiency augmented the severity of rheumatoid arthritis (RA)-like arthritis with inflammatory joint and bone erosion by modulating the Fcγ receptor of macrophages, indicating
arthritis 21849 by modulating the Fcγ receptor of macrophages, indicating a clear inhibitory effect of TLR2 toward arthritis [[85]].Regarding the relationship between RA and TLR7, a strong correlation between the disease activity
autoimmune disease 2115 balance of pro-apoptotic signals and growth factor.1. IntroductionSjögren’s syndrome (SS) is an autoimmune disease characterized by sicca symptoms including xerophthalmia and xerostomia, extraglandular manifestations
autoimmune disease 13207 apoptosis, whereas sFasL may be a pathological molecule that induces tissue damage [[57]]. In terms of autoimmune disease s, the functions and clinical significance of sFas and sFasL have not been clearly determined. Nozawa
autoimmune disease 13402 clearly determined. Nozawa et al. [[58]] reported that the level of sFas in the sera of patients with autoimmune disease s (including systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM), mixed connective
autoimmune disease 21029 including at least 10 species of TLRs in human are known, and some of the known TLRs are associated with autoimmune disease s. Abdollahi-Roodsaz et al. reported that IL-1 receptor antagonist (IL-1rn−/−) knockout mice showed
autoimmune disease 29306 a TLR7 signaling pathway might be a candidate for treating pSS.Regarding the role of type I IFN in autoimmune disease s including SLE and pSS, an involvement of endogenous virus-like genomic repeat elements was reported
autoimmune disease 38826 signaling in SS in accordance with the progress of research into the importance of innate immunity in autoimmune disease s such as SS. The roles of TLR7–9 as sensors for nucleic acids of exogenous microbes have been revealed,
connective tissue disease 13513 diseases (including systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM), mixed connective tissue disease (MTCD), and SS) was significantly higher than that in healthy subjects. They also reported that sFasL
dermatomyositis 13482 sera of patients with autoimmune diseases (including systemic lupus erythematosus (SLE), polymyositis/ dermatomyositis (PM/DM), mixed connective tissue disease (MTCD), and SS) was significantly higher than that in healthy
mixed connective tissue disease 13507 autoimmune diseases (including systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM), mixed connective tissue disease (MTCD), and SS) was significantly higher than that in healthy subjects. They also reported that sFasL
myositis 13473 in the sera of patients with autoimmune diseases (including systemic lupus erythematosus (SLE), poly myositis /dermatomyositis (PM/DM), mixed connective tissue disease (MTCD), and SS) was significantly higher than
myositis 13489 patients with autoimmune diseases (including systemic lupus erythematosus (SLE), polymyositis/dermato myositis (PM/DM), mixed connective tissue disease (MTCD), and SS) was significantly higher than that in healthy
rheumatoid arthritis 21667 IL-17 production. Abdollahi-Roodsaz et al. also reported that TLR2 deficiency augmented the severity of rheumatoid arthritis (RA)-like arthritis with inflammatory joint and bone erosion by modulating the Fcγ receptor of macrophages,
systemic lupus erythematosus 13433 [[58]] reported that the level of sFas in the sera of patients with autoimmune diseases (including systemic lupus erythematosus (SLE), polymyositis/dermatomyositis (PM/DM), mixed connective tissue disease (MTCD), and SS) was significantly

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