Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
Sjögren's syndrome 1 rheumatologydiseases
arthritis 10 rheumatologydiseases
autoimmune disease 8 rheumatologydiseases
myopathy 1 rheumatologydiseases
myositis 3 rheumatologydiseases
rheumatoid arthritis 9 rheumatologydiseases
systemic lupus erythematosus 4 rheumatologydiseases
vasculitis 2 rheumatologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
Sjögren's syndrome 22031 SLEDAI > 10).dState the disease controls categories from this article: 15 rheumatoid arthritis, 15 Sjögren's syndrome , 13 systemic sclerosis.eState the disease controls categories from this article: 12 multiple sclerosis,
arthritis 17697 (STRAP is inversely correlated with SLEDAI)Wang et al. 23PBMC6 active SLE, 6 stable SLE /6 rheumatoid arthritis (RA), 6 age‐ and sex‐matched HCMALDI‐TOF/TOF MS iTRAQ‐labelled452 proteins in total /67 differentially
arthritis 22017 nephritis (high SLEDAI > 10).dState the disease controls categories from this article: 15 rheumatoid arthritis , 15 Sjögren's syndrome, 13 systemic sclerosis.eState the disease controls categories from this article:
arthritis 22303 polyneuropathy, 10 psychotic syndromes.fState the disease controls categories from this article: 6 rheumatoid arthritis , 6 systemic sclerosis.gState the disease controls categories from this article: 6 rheumatoid arthritis,
arthritis 22406 arthritis, 6 systemic sclerosis.gState the disease controls categories from this article: 6 rheumatoid arthritis , 6 systemic sclerosis.hState the disease controls categories from this article: 49 rheumatoid arthritis,
arthritis 22510 arthritis, 6 systemic sclerosis.hState the disease controls categories from this article: 49 rheumatoid arthritis , 11 polymyositis.John Wiley & Sons, LtdTypes of specimensIn the 25 selected articles, a variety of specimen
arthritis 47954 lipoprotein subclasses were associated with increased atherosclerosis risk, in patients with rheumatoid arthritis 64.Urinary prostaglandin H2D‐isomerase (PGDS) was identified as a candidate biomarker for LN activity
arthritis 49638 Additionally, serum pro‐hepcidin levels were shown to reflect disease activity, in patients with rheumatoid arthritis 76.Biomarkers associated with NPSLESLE affects both the central and the peripheral nervous system. NPSLE
arthritis 56492 the discrimination between SLE patients with LN, SLE patients without LN and patients with rheumatoid arthritis 104.Transthyretin and haptoglobin (Hp) were upregulated in urine samples from active LN 30 patients,
arthritis 57222 Additionally, increased serum levels of transthyretin were associated with the severity of rheumatoid arthritis , suggesting a role in disease pathogenesis 109. The main biological role of Hp is to bind haemoglobin,
arthritis 57563 immunomodulatory properties. Hp expression was associated with inflammatory autoimmune diseases, including arthritis and SLE, and as a marker of disease activity 110. Plasma levels of Hp were associated with disease severity
autoimmune disease 11626 proteins with m/z ratio 4070.09, 7770.45, 28 045.1, 3376.02 differentiate samples of SLE from other autoimmune disease s and HC with accuracy of 78.1, 85.8 and 90%, respectivelySLE diagnosisIizuka et al. 13Serum30 CNS‐SLE
autoimmune disease 16582 downregulated)CSF /Blind test group: 12 NPSLE before treatment /12 lumbar disc herniation, 9 with other autoimmune disease s with NP involvement CSF /1 NPSLE incubated with anti‐ubiquitin polyclonal Ab for 2 hr /same CSF sample
autoimmune disease 45259 affect the sensitivity of the cell to apoptose 54, 55, 56. CKs have also been associated with other autoimmune disease s. Particularly, increased levels of anti‐CK18 and anti‐CK19 antibodies were observed in the sera
autoimmune disease 46606 cascade. Antibodies against annexins A5 and A2 were detected in thrombotic‐associated diseases and other autoimmune disease s besides SLE, such as primary antiphospholipid syndrome and systemic sclerosis 60. Besides annexin A5,
autoimmune disease 46958 Serum anti‐annexin A2 antibody levels discriminated PLN patients, not only from patients with other autoimmune disease s and healthy controls, but also from patients with a membranous form of LN 11. Annexin A2 was also identified
autoimmune disease 56145 pathophysiological processes 101, 102. Evidence revealed that α‐enolase plays a role in systemic autoimmune disease s. Anti‐α‐enolase antibodies were present in patients with SLE with active LN and other autoimmune
autoimmune disease 56256 diseases. Anti‐α‐enolase antibodies were present in patients with SLE with active LN and other autoimmune disease s such as systemic sclerosis 103. In addition, anti‐α‐enolase IgG2 levels were increased in LN serum,
autoimmune disease 57532 protein with antioxidant and immunomodulatory properties. Hp expression was associated with inflammatory autoimmune disease s, including arthritis and SLE, and as a marker of disease activity 110. Plasma levels of Hp were associated
myopathy 56932 (T4) and retinol 105. It has been associated with numerous disorders including, familial amyloid cardio myopathy and senile systemic amyloidosis 106, 107. A pilot study showed that transthyretin levels were upregulated
myositis 22528 sclerosis.hState the disease controls categories from this article: 49 rheumatoid arthritis, 11 poly myositis .John Wiley & Sons, LtdTypes of specimensIn the 25 selected articles, a variety of specimen types obtained
myositis 54473 (EF‐1γ) was identified as a target antigen of serum antibodies in patients with SLE compared with RA, poly myositis and healthy controls 17. Elongation factor 1 (EF1) is a major translational factor that consists of
myositis 55074 for antibodies in patients with proliferative LN 11 and in patients with SLE compared with RA, poly myositis and healthy controls 17. GAPDH was also downregulated in PBMCs from patients with SLE compared with
rheumatoid arthritis 17686 activity (STRAP is inversely correlated with SLEDAI)Wang et al. 23PBMC6 active SLE, 6 stable SLE /6 rheumatoid arthritis (RA), 6 age‐ and sex‐matched HCMALDI‐TOF/TOF MS iTRAQ‐labelled452 proteins in total /67 differentially
rheumatoid arthritis 22006 other than nephritis (high SLEDAI > 10).dState the disease controls categories from this article: 15 rheumatoid arthritis , 15 Sjögren's syndrome, 13 systemic sclerosis.eState the disease controls categories from this article:
rheumatoid arthritis 22292 polyneuropathy, 10 psychotic syndromes.fState the disease controls categories from this article: 6 rheumatoid arthritis , 6 systemic sclerosis.gState the disease controls categories from this article: 6 rheumatoid arthritis,
rheumatoid arthritis 22395 rheumatoid arthritis, 6 systemic sclerosis.gState the disease controls categories from this article: 6 rheumatoid arthritis , 6 systemic sclerosis.hState the disease controls categories from this article: 49 rheumatoid arthritis,
rheumatoid arthritis 22499 rheumatoid arthritis, 6 systemic sclerosis.hState the disease controls categories from this article: 49 rheumatoid arthritis , 11 polymyositis.John Wiley & Sons, LtdTypes of specimensIn the 25 selected articles, a variety of specimen
rheumatoid arthritis 47943 Apo B lipoprotein subclasses were associated with increased atherosclerosis risk, in patients with rheumatoid arthritis 64.Urinary prostaglandin H2D‐isomerase (PGDS) was identified as a candidate biomarker for LN activity
rheumatoid arthritis 49627 Additionally, serum pro‐hepcidin levels were shown to reflect disease activity, in patients with rheumatoid arthritis 76.Biomarkers associated with NPSLESLE affects both the central and the peripheral nervous system. NPSLE
rheumatoid arthritis 56481 enabling the discrimination between SLE patients with LN, SLE patients without LN and patients with rheumatoid arthritis 104.Transthyretin and haptoglobin (Hp) were upregulated in urine samples from active LN 30 patients,
rheumatoid arthritis 57211 controls 108. Additionally, increased serum levels of transthyretin were associated with the severity of rheumatoid arthritis , suggesting a role in disease pathogenesis 109. The main biological role of Hp is to bind haemoglobin,
systemic lupus erythematosus 63 Title: Journal of Cellular and Molecular MedicineBiomarkers of systemic lupus erythematosus identified using mass spectrometry‐based proteomics: a systematic reviewOrthodoxia NicolaouAndreas
systemic lupus erythematosus 757 spectrometry technologies have created new opportunities for discovering novel protein biomarkers in systemic lupus erythematosus (SLE). We performed a systematic review of published reports on proteomic biomarkers identified in SLE
systemic lupus erythematosus 20491 immunosorbent assay; PBMCs: peripheral blood mononuclear cells; N/A: not applicable: without validation; SLE: systemic lupus erythematosus ; Conf.: confirmation techniques; WB: Western blot analysis; IHC: immunohistochemistry; DC: disease controls;
systemic lupus erythematosus 40449 diagnosisPLN: proliferative lupus nephritis; MLN: membranous lupus nephritis; LN: lupus nephritis; SLE: systemic lupus erythematosus ; SDS‐PAGE: sodium dodecyl sulphate–polyacrylamide gel electrophoresis; LC: liquid chromatography;
vasculitis 19981 diagnosis SLE genetic basis LN diagnosis LN: lupus nephritis; ANCA: antineutrophil cytoplasmic antibody vasculitis ; GN: glomerulonephritis; 2‐DE: two‐dimensional gel electrophoresis; MALDI: matrix‐assisted laser
vasculitis 41028 desorption/ionization; TOF: time‐of‐flight mass spectrometry; ANCA: antineutrophil cytoplasmic antibody vasculitis ; GN: glomerulonephritis; PBMCs: peripheral blood mononuclear cells; ESI‐Q: electrospray ionization

You must be authorized to submit a review.