Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis

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Annotation Summary

Term Occurence Count Dictionary
septic arthritis 2 rheumatologydiseases
vancomycin 1 rheumatologydiseasesdrugs
arthritis 2 rheumatologydiseases
fasciitis 2 rheumatologydiseases
gout 1 rheumatologydiseases
methicillin 2 rheumatologydiseasesdrugs
osteomyelitis 4 rheumatologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
methicillin 10406 bacteria, present in 30%–60% of cases [[25]].2.5. Resistance of S. aureus in DFIsThe prevalence of methicillin -resistant S. aureus (MRSA) in DFI varies among countries with an exacerbation in countries that are
methicillin 16413 α-toxin-encoding gene hla independently of the grade [[110]]. However, this proportion varies between methicillin -susceptible S. aureus (MSSA) and MRSA. The α-hemolysin gene was significantly less present in MRSA
vancomycin 12004 presentation and outcomes between MRSA and other pathogens [[81],[82],[83]].Finally, some cases of DFIs due to vancomycin -resistant S. aureus have been described [[84],[85]]. This type of resistance remains uncommon.2.6. PathogenesisThe
Select Disease Character Offset Disease Term Instance
arthritis 18408 genome. This cluster is present in almost all S. aureus strains. These toxins play a role in septic arthritis and could help community-acquired MRSA (CA-MRSA) to survive in human blood during infection [[120],[121]].
arthritis 33165 beneath the skin and subcutaneous tissue, such as deep abscess, lymphangitis, osteomyelitis, septic arthritis or fasciitis There must not be any systemic inflammatory response (see Grade 4)Grade 4Regardless of
fasciitis 19264 [[126]].The PVL-positive strains are responsible for SSTIs (abscesses, furuncles, carbuncles or necrotizing fasciitis ), severe necrotizing pneumonia and aggressive bone and joint infections [[48],[105],[127],[128]]. However
fasciitis 33178 skin and subcutaneous tissue, such as deep abscess, lymphangitis, osteomyelitis, septic arthritis or fasciitis There must not be any systemic inflammatory response (see Grade 4)Grade 4Regardless of the local infection,
gout 32906 sanguineous secretion) Other causes of inflammation of the skin must be eliminated (for example: trauma, gout , acute Charcot foot, fracture, thrombosis, venous stasis)Grade 3-Erythema >2 cm and one of the findings
osteomyelitis 1671 non-toxinogenic strains seem to remain localized in deep structures and bone involving diabetic foot osteomyelitis . Testing the virulence profile of bacteria seems to be a promising way to predict the behavior of S.
osteomyelitis 5986 toxinogenic manifestations could be clearly diagnosed in DFI.2.2. OsteomyelitisInfection of bone, or osteomyelitis , is found in ~50%–60% of patients hospitalized for a DFI and ~10%–20% of apparently less severe
osteomyelitis 6455 through the cortical bone and into the medullary cavity. The clinical presentation of diabetic foot osteomyelitis (DFOM) can vary with the site, the presence of any associated abscess or soft tissue involvement, the
osteomyelitis 33143 involving structures beneath the skin and subcutaneous tissue, such as deep abscess, lymphangitis, osteomyelitis , septic arthritis or fasciitis There must not be any systemic inflammatory response (see Grade 4)Grade
septic arthritis 18401 the core genome. This cluster is present in almost all S. aureus strains. These toxins play a role in septic arthritis and could help community-acquired MRSA (CA-MRSA) to survive in human blood during infection [[120],[121]].
septic arthritis 33158 structures beneath the skin and subcutaneous tissue, such as deep abscess, lymphangitis, osteomyelitis, septic arthritis or fasciitis There must not be any systemic inflammatory response (see Grade 4)Grade 4Regardless of

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