Cellular senescence in osteoarthritis pathology.

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Term Occurence Count Dictionary
arthritis 8 rheumatologydiseases
osteoarthritis 2 rheumatologydiseases
osteophyte 3 rheumatologydiseases
rheumatoid arthritis 1 rheumatologydiseases
synovitis 3 rheumatologydiseases

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arthritis 45 Title: Aging CellCellular senescence in osteo arthritis pathologyAlternative Title: K. McCulloch et al.Kendal McCullochGary J. LitherlandTaranjit Singh Rai1Institute
arthritis 764 also impair function and have been implicated in the pathogenesis of many age‐related diseases. Osteo arthritis (OA), a severely debilitating chronic condition characterized by progressive tissue remodeling and loss
arthritis 1825 touching upon various epigenetic alterations associated with both OA and senescence.IntroductionOsteo arthritis (OA)Osteoarthritis (OA) is the most prevalent disease of synovial joints (around 4.7% of global population
arthritis 1844 various epigenetic alterations associated with both OA and senescence.IntroductionOsteoarthritis (OA)Osteo arthritis (OA) is the most prevalent disease of synovial joints (around 4.7% of global population for knee and
arthritis 9688 the context of OA pathology and highlight potential epigenetic treatment options.Senescence in osteo arthritis pathologyAlthough there are multiple joint tissues and cell types involved in OA pathology, chondrocytes
arthritis 14424 conditions of the joint, although exacerbated hypoxia may drive synovial inflammation in rheumatoid arthritis (RA) (an age‐related autoimmune inflammatory joint disease characterized by joint destruction, chronic
arthritis 33384 in the inflammatory response, joint damage, and also autoantibody production in collagen‐induced arthritis (CIA) murine models. Xiao et al. (2016) further highlighted the therapeutic potential of JQ1 in inflammatory
arthritis 33504 murine models. Xiao et al. (2016) further highlighted the therapeutic potential of JQ1 in inflammatory arthritis , stating JQ1 decreased the proliferation of RASFs, as well as decreasing the production of various cytokines,
osteoarthritis 40 Title: Aging CellCellular senescence in osteoarthritis pathologyAlternative Title: K. McCulloch et al.Kendal McCullochGary J. LitherlandTaranjit Singh Rai1Institute
osteoarthritis 9683 cells in the context of OA pathology and highlight potential epigenetic treatment options.Senescence in osteoarthritis pathologyAlthough there are multiple joint tissues and cell types involved in OA pathology, chondrocytes
osteophyte 3283 exhibits progressive degeneration of the articular cartilage, formation of bony peripheral outgrowths ( osteophyte s), changes in subchondral bone and thickening of both the synovium and ligaments (Fig. 2B), and in
osteophyte 4500 degradation; synovial hypertrophy often accompanied by inflammation (synovitis); formation of peri‐articular osteophyte s; osteosclerosis of subchondral bone.Cellular senescenceIn 1961, Leonard Hayflick and Paul Moorhead
osteophyte 10919 are expressed in OA cartilage and may contribute to dysregulated osteogenesis and the formation of osteophyte s (Pfander et al., 2001; Hashimoto et al., 2002; Enomoto et al., 2003). Chondrocyte SASP is known
rheumatoid arthritis 14413 the hypoxic conditions of the joint, although exacerbated hypoxia may drive synovial inflammation in rheumatoid arthritis (RA) (an age‐related autoimmune inflammatory joint disease characterized by joint destruction, chronic
synovitis 3428 thickening of both the synovium and ligaments (Fig. 2B), and in many cases synovial inflammation ( synovitis ), which is thought to be an important driver of early pathology (Benito et al., 2005). Pathologic roles
synovitis 4458 changes, for example, cartilage degradation; synovial hypertrophy often accompanied by inflammation ( synovitis ); formation of peri‐articular osteophytes; osteosclerosis of subchondral bone.Cellular senescenceIn
synovitis 14659 dysfunction of innate and adaptive immune responses) contributing to pathology (Ng et al., 2010). As synovitis is an acknowledged feature of OA, it is plausible that enhanced hypoxia could play a similar pathologic

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