The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology.

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Term Occurence Count Dictionary
osteophyte 6 rheumatologydiseases
rheumatoid arthritis 3 rheumatologydiseases
arthritis 10 rheumatologydiseases
osteoarthritis 4 rheumatologydiseases

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arthritis 1728 regeneration after fracture and are involved in the pathology of inflammatory diseases as rheumatoid arthritis which manifests mainly in joints. Possibly, they might also play a role in pathogenesis of degenerative
arthritis 1872 Possibly, they might also play a role in pathogenesis of degenerative joint disorders, such as osteo arthritis . All together, accumulating data imply that sensory and sympathetic neurotransmitters have crucial trophic
arthritis 4117 tyrosine-hydroxylase (TH) or neuropeptide Y (NPY) or both, in synovial tissue contribute to rheumatoid arthritis (RA) [[9]]. Loss of sensory joint innervation during aging is suggested to accelerate degenerative cartilage
arthritis 4300 to accelerate degenerative cartilage alterations which contribute to development of spontaneous osteo arthritis (OA) in mice [[10]]. Capsaicin-sensitive sensory neurons contribute to the maintenance of tibial and
arthritis 11024 β2-adrenoceptor; Iso, isoproterenol; Pro, propranolol.Sensory and sympathetic nerve fibers in osteo arthritis OA, a degenerative disorder of diathrodial joints culminating in the irreversible destruction of the
arthritis 24707 marrow-derived stem cell; CL, calcitonin gene-related peptide; NK1R, neurokinin 1 receptor; OA, osteo arthritis ; PACAP, pituitary adenylate cyclase-activating polypeptide; RA, rheumatoid arthritis; RAMP, receptor
arthritis 24792 receptor; OA, osteoarthritis; PACAP, pituitary adenylate cyclase-activating polypeptide; RA, rheumatoid arthritis ; RAMP, receptor activity-modifying protein; VIP, vasoactive intestinal peptide.Notably, compared with
arthritis 25320 showed that treatment with VIP significantly reduced the incidence and severity of collagen-induced arthritis , abrogating joint swelling and the destruction of cartilage and bone. These therapeutic effects were
arthritis 35056 factors determine the switch [[73]]. During development or under inflammatory conditions such as in arthritis or OA, sympathetic innervation of bone might change, leading to completely different control of bone
arthritis 47205 rheumatic diseases’, edited by Rainer Straub. Other articles in this series can be found at http:// arthritis -research.com/series/neurology
osteoarthritis 1867 joints. Possibly, they might also play a role in pathogenesis of degenerative joint disorders, such as osteoarthritis . All together, accumulating data imply that sensory and sympathetic neurotransmitters have crucial trophic
osteoarthritis 4295 suggested to accelerate degenerative cartilage alterations which contribute to development of spontaneous osteoarthritis (OA) in mice [[10]]. Capsaicin-sensitive sensory neurons contribute to the maintenance of tibial and
osteoarthritis 11019 β2, β2-adrenoceptor; Iso, isoproterenol; Pro, propranolol.Sensory and sympathetic nerve fibers in osteoarthritis OA, a degenerative disorder of diathrodial joints culminating in the irreversible destruction of the
osteoarthritis 24702 bone marrow-derived stem cell; CL, calcitonin gene-related peptide; NK1R, neurokinin 1 receptor; OA, osteoarthritis ; PACAP, pituitary adenylate cyclase-activating polypeptide; RA, rheumatoid arthritis; RAMP, receptor
osteophyte 12619 These authors and others have also shown sympathetic and perivascular sensory innervation of tibial osteophyte s, the latter localized to the base of osteophytes [[30],[31]]. Sensory innervation of osteophytes may
osteophyte 12668 sympathetic and perivascular sensory innervation of tibial osteophytes, the latter localized to the base of osteophyte s [[30],[31]]. Sensory innervation of osteophytes may explain why radiological grading of osteophytosis
osteophyte 12716 tibial osteophytes, the latter localized to the base of osteophytes [[30],[31]]. Sensory innervation of osteophyte s may explain why radiological grading of osteophytosis is associated with reported pain severity [[32]].
osteophyte 37019 increased sensitivity or number in OA joints [[37]]. Both types of nerve fibers have been localized in osteophyte s, and perivascular SP-positive nerve fibers were found at the base of osteophytes in horse metacarpophalangeal
osteophyte 37100 been localized in osteophytes, and perivascular SP-positive nerve fibers were found at the base of osteophyte s in horse metacarpophalangeal OA [[30],[31]]. In addition to SP-positive sensory nerve fibers, cells
osteophyte 37791 innervation and their respective neurotransmitters contribute to abnormal subchondral bone remodeling and osteophyte formation during the pathogenesis of OA is mostly unknown.Sensory neuropeptides and catecholamines and
rheumatoid arthritis 1717 for bone regeneration after fracture and are involved in the pathology of inflammatory diseases as rheumatoid arthritis which manifests mainly in joints. Possibly, they might also play a role in pathogenesis of degenerative
rheumatoid arthritis 4106 characterized by tyrosine-hydroxylase (TH) or neuropeptide Y (NPY) or both, in synovial tissue contribute to rheumatoid arthritis (RA) [[9]]. Loss of sensory joint innervation during aging is suggested to accelerate degenerative cartilage
rheumatoid arthritis 24781 neurokinin 1 receptor; OA, osteoarthritis; PACAP, pituitary adenylate cyclase-activating polypeptide; RA, rheumatoid arthritis ; RAMP, receptor activity-modifying protein; VIP, vasoactive intestinal peptide.Notably, compared with

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