Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis?

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arthritis 5 rheumatologydiseases
osteoarthritis 2 rheumatologydiseases
rheumatoid arthritis 1 rheumatologydiseases

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arthritis 185 Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteo arthritis ?Rikang WangShuai ZhangRahul PrevinDi ChenYi JinGuangqian Zhou1Shenzhen Key Laboratory for Anti-ageing
arthritis 1010 11/2018Publication date (collection): 12/2018AbstractChondrocyte dysfunction occurs during the development of osteo arthritis (OA), typically resulting from a deleterious increase in oxidative stress. Accordingly, strategies for
arthritis 2006 next-generation therapies to prevent OA development and to slow OA progression.1. IntroductionOsteo arthritis (OA), a leading cause of disability, is a prevalent rheumatic disease characterized by articular cartilage
arthritis 15573 β-catenin upregulated in chondrocytes following to GSK3β inhibition may be adequate to induce osteo arthritis in vivo [[74]]. GSK3β is inhibited by AKT, so it was not surprising to see that GSK3 activates FoxO
arthritis 20232 hydroperoxide (t-BHP) (Table 2) [[6]]. These phenomena are similar to those observed in rheumatoid arthritis synovial tissue, such as synovial cells and macrophages, in which FoxO1 and FoxO4 are phosphorylated
osteoarthritis 1005 11/2018Publication date (collection): 12/2018AbstractChondrocyte dysfunction occurs during the development of osteoarthritis (OA), typically resulting from a deleterious increase in oxidative stress. Accordingly, strategies for
osteoarthritis 15568 of β-catenin upregulated in chondrocytes following to GSK3β inhibition may be adequate to induce osteoarthritis in vivo [[74]]. GSK3β is inhibited by AKT, so it was not surprising to see that GSK3 activates FoxO
rheumatoid arthritis 20221 tert-butyl hydroperoxide (t-BHP) (Table 2) [[6]]. These phenomena are similar to those observed in rheumatoid arthritis synovial tissue, such as synovial cells and macrophages, in which FoxO1 and FoxO4 are phosphorylated

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