The Epidemiology of Hepatitis D Virus in North Africa: A Systematic Review and Meta-Analysis

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Term Occurence Count Dictionary
hepatitis B 5 infectiousdiseases
hepatitis D 11 infectiousdiseases
syphilis 1 infectiousdiseases
viral hepatitis 5 infectiousdiseases

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hepatitis B 1288 particularly in developing countries. The virus causes a more severe disease than mono infection with hepatitis B virus (HBV). The epidemiology of HDV is not well documented in North Africa, which is known to be endemic
hepatitis B 1571 infection and also attempted to identify factors associated with hepatitis D positive status among chronic hepatitis B patients in North Africa. Methods The electronic databases PubMed, Embase, Scopus, Science Direct, Web
hepatitis B 4557 structure. The RNA encodes a protein called the delta antigen, which is subsequently packaged with hepatitis B surface antigen (HBsAg) and encased in an envelope [[3], [4]]. The HDV RNA is unique in its ability
hepatitis B 4940 self-binding [[5], [6]].Different studies have shown that HDV infection aggravates the course of a hepatitis B virus (HBV) coinfection, accelerating progression to cirrhosis and leading to early decompensation of
hepatitis B 17310 chronic viral hepatitis that progresses to cirrhosis and increases the risk of liver cancer compared to hepatitis B and C viruses [[64]]. Epidemiological studies on the prevalence of HDV infection in North Africa are
hepatitis D 1529 we explored the prevalence of HDV infection and also attempted to identify factors associated with hepatitis D positive status among chronic hepatitis B patients in North Africa. Methods The electronic databases
hepatitis D 1964 related keywords, including North Africa, names of countries in the region, and all permutations of hepatitis D virus. The estimated prevalence of HDV in North Africa was calculated as an average of the pooled infection
hepatitis D 2150 an average of the pooled infection prevalence in each country weighted by the ratio of the country's hepatitis D virus population to the study's sample size in the survey data analysis. Findings A total of 312 studies
hepatitis D 14410 the general population (asymptomatic and without evidence of hepatic diseases), the presence of anti hepatitis D virus among patients with liver diseases and HBsAg positive was statistically significant (P< 0.001)
hepatitis D 17773 These studies include the data of 4,709 individuals. This review provides descriptive information on hepatitis D in the general populations and in blood donors, as well as in special subgroups, such as pregnant women
hepatitis D 22640 North Africa have not been studied and we did not identify any study showing an association between hepatitis D virus seroprevalence and HIV, HCV coinfection, intravenous drug use, and other HDV risk factors. However,
hepatitis D 26351 North Africa.Figure 1Flow chart of article selection for the systematic review and meta-analysis of hepatitis D virus epidemiology in North Africa (1998-2017).Figure 2Seroepidemiology of hepatitis D virus in North
hepatitis D 26438 meta-analysis of hepatitis D virus epidemiology in North Africa (1998-2017).Figure 2Seroepidemiology of hepatitis D virus in North African populations in studies published during 1998–2017.Figure 3Forest plot of the
hepatitis D 26570 African populations in studies published during 1998–2017.Figure 3Forest plot of the seroprevalence of hepatitis D virus in different populations in North Africa.Table 1Prevalence of antihepatitis D virus and hepatitis
hepatitis D 26654 seroprevalence of hepatitis D virus in different populations in North Africa.Table 1Prevalence of anti hepatitis D virus and hepatitis D virus RNA in HBsAg-positive populations in North Africa.YearCategoryTested (n)Anti-HDVHDV
hepatitis D 26676 hepatitis D virus in different populations in North Africa.Table 1Prevalence of antihepatitis D virus and hepatitis D virus RNA in HBsAg-positive populations in North Africa.YearCategoryTested (n)Anti-HDVHDV RNAn (%)95%
syphilis 23381 intravenous drug users but among HIV-positive homosexual men, often presenting with liver flare-ups and syphilis independently of the use of successful antiretroviral therapy [[75]].Several limitations are associated
viral hepatitis 3950 (HDV) is a unique RNA agent. It is the smallest infectious agent, and it causes the most severe form of viral hepatitis in humans. The viral genome consists of one single-stranded circular RNA molecule of about 1.7 kb
viral hepatitis 17214 a silent threat, particularly in developing countries. The virus can cause a severe form of chronic viral hepatitis that progresses to cirrhosis and increases the risk of liver cancer compared to hepatitis B and C viruses
viral hepatitis 24638 as detection of HBV core antibodies or DNA testing. This could undermine the prevalence estimates of viral hepatitis from the collected data.Despite the limitations of the results presented here, this review highlights
viral hepatitis 25128 results are relevant and topical for countries that are planning their national strategies against viral hepatitis . Better estimates are important for resources planning and will allow more accurate monitoring of the
viral hepatitis 25733 Libya has shown high prevalence rates of HCV, HBV and HIV, which may influence the geo-epidemiology of viral hepatitis in North Africa and European countries, particularly those on the Mediterranean basin [[76]–[79]].This

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