Flubendazole as a macrofilaricide: History and background

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Annotation Summary

Term Occurence Count Dictionary
abscess 1 infectiousdiseases
doxycycline 1 infectiousdiseasesdrugs
filariasis 2 infectiousdiseases
ivermectin 4 infectiousdiseasesdrugs
onchocerciasis 10 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
doxycycline 3705 unlikely to be cost-effective.Antibiotics that deplete the Wolbachia symbiont from filariae, most notably doxycycline , can kill adult parasites after an extended course of therapy [[8],[9]]; proof-of-concept that this
ivermectin 2398 until all adult worms in a locale have died (5 to 15 years). The drugs used in MDA campaigns include ivermectin in onchocerciasis areas and diethylcarbamazine in areas in which only LF is present; both agents are
ivermectin 2570 which only LF is present; both agents are combined with albendazole for use in LF control. The use of ivermectin or diethylcarbamazine in areas coendemic with Loa loa is problematic due to the danger of severe adverse
ivermectin 4089 target product profiles (TPPs) for a new macrofilaricide. Recently, the combination of albendazole + ivermectin + diethylcarbamazine was shown to have macrofilaricidal activity against W. bancrofti after a single
ivermectin 6965 the development of FBZ for this indication was stopped, at least in part due to the availability of ivermectin for onchocerciasis control.New interest in macrofilaricides, particularly for the elimination of onchocerciasis,
Select Disease Character Offset Disease Term Instance
abscess 6067 macrofilaricidal efficacy against O. volvulus. However, this formulation and dosing schedule led to abscess formation at the injection site [[17]]. At about the same time, a putative prodrug of FBZ, UMF-078,
filariasis 1583 summarizes some of the lessons learned from it.Elimination of the human filarial diseases lymphatic filariasis (LF) and onchocerciasis is a formal objective of the global health community [[1],[2]]. Decades-long
filariasis 12058 models. Given the toxicological profile of FBZ and the incompatability of injectable formulations for filariasis control programs, it was concluded that parenteral FBZ should not be developed as an alternative to
onchocerciasis 1149 part of an effort to stimulate the discovery and development of new macrofilaricides, particularly for onchocerciasis , research has recently been devoted to the development of new formulations that would afford high oral
onchocerciasis 1603 the lessons learned from it.Elimination of the human filarial diseases lymphatic filariasis (LF) and onchocerciasis is a formal objective of the global health community [[1],[2]]. Decades-long control programs leading
onchocerciasis 2169 parasites. The long-lasting reduction of the microfilarial burden effectively prevents transmission and, in onchocerciasis patients, the development of dermal and ocular pathology. Elimination can be attained if transmission
onchocerciasis 2412 worms in a locale have died (5 to 15 years). The drugs used in MDA campaigns include ivermectin in onchocerciasis areas and diethylcarbamazine in areas in which only LF is present; both agents are combined with albendazole
onchocerciasis 2995 macrofilaricide would significantly accelerate progress toward elimination of filariases, in particular onchocerciasis [[5]–[7]]. Macrofilaricidal regimens compatible with the current requirements of MDA programs (brief
onchocerciasis 4411 breakthrough for the elimination of LF. However, it is not known whether similar results could be obtained in onchocerciasis , and the inclusion of diethylcarbamazine in a regimen intended for broad use in onchocerciasis regions
onchocerciasis 4506 obtained in onchocerciasis, and the inclusion of diethylcarbamazine in a regimen intended for broad use in onchocerciasis regions is not without significant safety concerns. Against this background, there has been a recent
onchocerciasis 5077 consideration of flubendazole (FBZ) as a potential macrofilaricide for human use in campaigns against onchocerciasis and LF was outlined in 2011 [[16]]. To briefly summarize, experiments sponsored by WHO in the 1970s
onchocerciasis 6980 of FBZ for this indication was stopped, at least in part due to the availability of ivermectin for onchocerciasis control.New interest in macrofilaricides, particularly for the elimination of onchocerciasis, prompted
onchocerciasis 7073 ivermectin for onchocerciasis control.New interest in macrofilaricides, particularly for the elimination of onchocerciasis , prompted a reevaluation of the potential of FBZ for this purpose [[16]]. As noted, experiments in animal

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