Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA.

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hepatitis B 92 Title: World Journal of GastroenterologyHepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNAKazuma SekibaDepartment of Gastroenterology, Graduate School of Medicine, The University of
hepatitis B 2576 new avenue for the development of novel HBV therapeutics.Core tip: Recently, it has been shown that hepatitis B virus (HBV) RNAs have diverse biological functions in the pathogenesis of HBV. HBV RNAs may work as
hepatitis B 5420 1Hepatitis B virus genome structure. The 3.2-kb partially double-stranded relaxed circular DNA genome of the hepatitis B virus (HBV) is shown in the center. The surrounding colored arrows indicate the locations of the four
hepatitis B 5695 viral mRNA. Pol: Polymerase; DR1: Direct repeat 1; DR2: Direct repeat 2.Figure 2The life cycle of the hepatitis B virus. Hepatitis B virus (HBV) virions infect hepatocytes, and then rcDNA enters the nucleus and is
hepatitis B 9948 The expression level of miR-122 is decreased in HBV-producing cells and in liver tissue from chronic hepatitis B patients[[25],[32],[33]]. Furthermore, there is an inverse correlation between miR-122 expression level
hepatitis B 12027 of HBV replication was suggested to contribute to the development of persistent infection in chronic hepatitis B patients. However, there is insufficient direct evidence for this mechanism, and, therefore, further

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