Monocytes and Macrophages as Viral Targets and Reservoirs

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Annotation Summary

Term Occurence Count Dictionary
pneumonia 1 infectiousdiseases
AIDS 1 infectiousdiseases
Japanese encephalitis 4 infectiousdiseases
hepatitis C 1 infectiousdiseases
herpes zoster 1 infectiousdiseases

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Select Disease Character Offset Disease Term Instance
AIDS 29372 shift of macrophages to M2 due to the presence of IL-4 and IL-13, which favours the progression to AIDS [[11]]. Along with the above mentioned impairments, infected macrophages show phagocytosis impairments
Japanese encephalitis 24367 role of the “Trojan horse,” which is common in HIV [[1],[2],[11]], HCV [[38]], HCMV [[17]] and Japanese encephalitis virus (JEV) [[97]]. Viruses need to overcome a number of hurdles to be able to successfully infect and
Japanese encephalitis 44228 neuroinflammatory process [[125]]. It is known that microglial cells are a significant target for the Japanese encephalitis virus [[125]]. Seitz S. et al. (2018) [[125]] showed that PLX5622 treatment lead to a dramatically increased
Japanese encephalitis 50692 Mφ/microglial cells express higher level of IL-1α, TNFα, IL-1β, IL-12, IL-18 (PCR analysis).[[37],[38]]9 Japanese encephalitis virus (JEV), West Nile virus (WNV), Dengue virus (DENV)Flaviviridae(+) ssRNAHumanNeurotropic, CNS-Raw264.7
Japanese encephalitis 61110 virusPhagocytosis* Sialic acid sugars and glycolipidsN- * acetilneuraminic acid receptorNo replication[[34],[77]]5 Japanese encephalitis virus, West Nile virus, Dengue virusPhagocytosis* DC-SIGN or * DC-SIGNRTLR-2, TLR-3 and TLR-7, RIG-IReplication[[39],[40]]6CoxsackievirusesMacropinocytosis*
hepatitis C 33730 [[98],[114]].The long persistence in liver macrophages was observed for a member of Flaviviridae family—the hepatitis C virus, albeit in small quantities. It was detected in cells up to 9 years after therapy [[37]]. Chronic
herpes zoster 39574 reactivation of VZV, leading to widespread necrosis of glial cells and neurons [[70]]. Clinically, herpes zoster is associated with severe, acute pain and frequently, prolonged severe pain or post herpetic neuralgia.
pneumonia 47899 MφReaction of MφReference1Respiratory syncytial virus (RSV)Paramyxoviridae(−) ssRNAHumanBronchiolitis and pneumonia , severe acute lower-respiratory tract disease in children-In vitro model of persistently RSV-infected

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