Monocytes and Macrophages as Viral Targets and Reservoirs

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
pneumonia 1 infectiousdiseases
AIDS 1 infectiousdiseases
Japanese encephalitis 4 infectiousdiseases
hepatitis C 1 infectiousdiseases
herpes zoster 1 infectiousdiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
AIDS 29372 shift of macrophages to M2 due to the presence of IL-4 and IL-13, which favours the progression to AIDS [[11]]. Along with the above mentioned impairments, infected macrophages show phagocytosis impairments
Japanese encephalitis 24367 role of the “Trojan horse,” which is common in HIV [[1],[2],[11]], HCV [[38]], HCMV [[17]] and Japanese encephalitis virus (JEV) [[97]]. Viruses need to overcome a number of hurdles to be able to successfully infect and
Japanese encephalitis 44228 neuroinflammatory process [[125]]. It is known that microglial cells are a significant target for the Japanese encephalitis virus [[125]]. Seitz S. et al. (2018) [[125]] showed that PLX5622 treatment lead to a dramatically increased
Japanese encephalitis 50692 Mφ/microglial cells express higher level of IL-1α, TNFα, IL-1β, IL-12, IL-18 (PCR analysis).[[37],[38]]9 Japanese encephalitis virus (JEV), West Nile virus (WNV), Dengue virus (DENV)Flaviviridae(+) ssRNAHumanNeurotropic, CNS-Raw264.7
Japanese encephalitis 61110 virusPhagocytosis* Sialic acid sugars and glycolipidsN- * acetilneuraminic acid receptorNo replication[[34],[77]]5 Japanese encephalitis virus, West Nile virus, Dengue virusPhagocytosis* DC-SIGN or * DC-SIGNRTLR-2, TLR-3 and TLR-7, RIG-IReplication[[39],[40]]6CoxsackievirusesMacropinocytosis*
hepatitis C 33730 [[98],[114]].The long persistence in liver macrophages was observed for a member of Flaviviridae family—the hepatitis C virus, albeit in small quantities. It was detected in cells up to 9 years after therapy [[37]]. Chronic
herpes zoster 39574 reactivation of VZV, leading to widespread necrosis of glial cells and neurons [[70]]. Clinically, herpes zoster is associated with severe, acute pain and frequently, prolonged severe pain or post herpetic neuralgia.
pneumonia 47899 MφReaction of MφReference1Respiratory syncytial virus (RSV)Paramyxoviridae(−) ssRNAHumanBronchiolitis and pneumonia , severe acute lower-respiratory tract disease in children-In vitro model of persistently RSV-infected

You must be authorized to submit a review.