Past and future trends of Cryptosporidium in vitro research

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Annotation Summary

Term Occurence Count Dictionary
streptomycin 1 infectiousdiseasesdrugs
AIDS 7 infectiousdiseases
clofazimine 2 infectiousdiseasesdrugs
cryptosporidiosis 8 infectiousdiseases
nitazoxanide 3 infectiousdiseasesdrugs
penicillin G 1 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
clofazimine 47503 treatment against cryptosporidiosis, which may see the emergence of new drugs on the market. Currently, clofazimine and TU502HP inhibitors are both potential candidates, while clofazimine, as a repurposed-drug, may not
clofazimine 47575 drugs on the market. Currently, clofazimine and TU502HP inhibitors are both potential candidates, while clofazimine , as a repurposed-drug, may not need approval for new handlings. In parallel, there is an urgent need
nitazoxanide 3185 symptoms are present ([105]; [15]). There is only one FDA-approved drug treatment for cryptosporidiosis, nitazoxanide , which resolves diarrhoea after three or four days of treatment in most immunocompetent individuals
nitazoxanide 40164 existing medications) rather than the development of rational drug design-a costly tactic. To date, nitazoxanide is the only FDA approved treatment against infection by Cryptosporidium. However, as highlighted previously,
nitazoxanide 44115 anti-cryptosporidial drug candidate that is active against both C. parvum and C. hominis. Additionally, unlike nitazoxanide , KDU731 demonstrated in vivo efficacy in immunocompromised mice.Beside these large-scale studies, which
penicillin G 18995 acid, 4.0 mg of 4-aminobenzoic acid, 2.0 mg of calcium pantothenate, 0.1 U of insulin, 100 U of penicillin G , 100 mg of streptomycin, and 0.25 mg of amphotericin B per ml (pH 7.4) supported a ten-fold increase
streptomycin 19021 4-aminobenzoic acid, 2.0 mg of calcium pantothenate, 0.1 U of insulin, 100 U of penicillin G, 100 mg of streptomycin , and 0.25 mg of amphotericin B per ml (pH 7.4) supported a ten-fold increase in parasite abundance
Select Disease Character Offset Disease Term Instance
AIDS 1007 prolonged detrimental effects on the development of children, but also can be life threatening to HIV/ AIDS patients and transplant recipients. A variety of hosts can act as reservoirs, and Cryptosporidium can
AIDS 2197 years before Cryptosporidium spp. were identified as pathogens in humans ([78]). In the 1980s, when AIDS was becoming more widespread, it also became apparent that Cryptosporidium was prevalent among the immunocompromised
AIDS 3401 ([95]; [6]), but shows little efficacy in young children and immunocompromised individuals such as HIV/ AIDS patients ([6]). Despite the worldwide prevalence of Cryptosporidium, there remain a number of unanswered
AIDS 19896 membrane of chicken embryos (Hubbard broiler and White Leghorn breed)Naturally infected calf, infected AIDS patientN/A8 daysComplete life cycle[27]Human foetal lung, Porcine kidney, Primary chicken kidneyAIDS
AIDS 19997 AIDS patientN/A8 daysComplete life cycle[27]Human foetal lung, Porcine kidney, Primary chicken kidney AIDS patientMinimal Essential Media with Earle's Salts, 2% FBS7 daysComplete life cycle[26]HT29.74, Clone
AIDS 20131 Media with Earle's Salts, 2% FBS7 daysComplete life cycle[26]HT29.74, Clone of colorectal cell line HT29 AIDS patientRPMI-1640, 10% FBS, 24 mM sodium bicarbonate, 1 mM sodium pyruvate, 20 mM HEPES (for undifferentiated
AIDS 21223 only(Woodmansee and Joachim, 1983)Caco-2 (Colorectal adenocarcinoma)Experimentally infected goats and lambs, AIDS patient with persistent cryptosporidiosisN/A5 daysComplete life cycle(Buraud et al., 1991)Madin-Darby
cryptosporidiosis 790 Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe gastro-intestinal disease known as cryptosporidiosis . They are one of the most common causes of childhood diarrhoea worldwide, and infection can have prolonged
cryptosporidiosis 3166 chronic, even if no symptoms are present ([105]; [15]). There is only one FDA-approved drug treatment for cryptosporidiosis , nitazoxanide, which resolves diarrhoea after three or four days of treatment in most immunocompetent
cryptosporidiosis 4061 progress in in vitro culture and ‘omics investigations, before exploring the future challenges of cryptosporidiosis .Cryptosporidium: endogenous growth and life cycle1Cryptosporidium is widely considered to be an intracellular
cryptosporidiosis 21252 1983)Caco-2 (Colorectal adenocarcinoma)Experimentally infected goats and lambs, AIDS patient with persistent cryptosporidiosis N/A5 daysComplete life cycle(Buraud et al., 1991)Madin-Darby bovine kidney (MDBK)Naturally infected calves
cryptosporidiosis 26990 scaffold, which supported infection for two weeks ([28]). While the method provides a good model of in vivo cryptosporidiosis , the use of multiple cell lines including intestinal myofibroblasts and the need for specialist equipment
cryptosporidiosis 43707 This study therefore established Clofazimine as a potential repurposing candidate for the treatment of cryptosporidiosis . Lastly, Manjunatha et al. screened 6220 compounds against C. parvum in an infection assay in HCT-8
cryptosporidiosis 47417 infected patients.In summary, a lot of effort has been invested in the search for new treatment against cryptosporidiosis , which may see the emergence of new drugs on the market. Currently, clofazimine and TU502HP inhibitors
cryptosporidiosis 49679 genotype and pathogenicity, it would be possible to develop effective treatments and vaccines against cryptosporidiosis

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