Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy

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Term Occurence Count Dictionary
hepatitis B 1 infectiousdiseases
hepatitis C 1 infectiousdiseases
viral hepatitis 7 infectiousdiseases

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hepatitis B 2218 viral infection, alcohol-related cirrhosis, and nonalcoholic steatohepatitis (NASH) [[4]]. Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for most of HCC cases worldwide [[4], [5]];
hepatitis C 2246 alcohol-related cirrhosis, and nonalcoholic steatohepatitis (NASH) [[4]]. Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for most of HCC cases worldwide [[4], [5]]; however, NASH will likely
viral hepatitis 2515 successful HBV vaccination and effective anti-HCV drugs will significantly reduce the number of chronic viral hepatitis patient in the near future [[6]–[8]].In recent decades, accumulating evidences supported that the
viral hepatitis 4699 of HCC [[17]].In this review, we will summarize the phenotypes and functions of NK cells in chronic viral hepatitis , alcoholic liver disease, NASH, and HCC, and the progresses in NK cell-based immunotherapy for cancers
viral hepatitis 4905 for cancers but not limited to HCC are also reviewed.2. NK Cells in Chronic Viral HepatitisChronic viral hepatitis including HBV and HCV is the leading cause for the development of liver cirrhosis and subsequent HCC.
viral hepatitis 6435 receptor expression was normal [[18]]. The reduced percentage and impaired function of NK cells in chronic viral hepatitis patients were believed to contribute to the disease progression and the transformation of HCC.3. NK
viral hepatitis 7725 contributes to the development of alcohol-related HCC.4. NK Cells in NASHAlthough the incidence of chronic viral hepatitis decreases benefiting from the vaccinations and the advanced clinical therapies, the incidence of HCC
viral hepatitis 8858 enriched in healthy liver, and they play critical roles in the surveillance of HCC. Similar to chronic viral hepatitis , the number of peripheral NK cells, especially CD56dimCD16+ NK cells, dramatically reduced in HCC patients
viral hepatitis 21288 impairment of the function of NK cells was observed in many types of liver diseases including chronic viral hepatitis , alcoholic and nonalcoholic steatohepatitis, and HCC. Several approaches have been developed to boost

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