A suppurative thyroiditis and perineal subcutaneous abscess related with aspergillus fumigatus: a case report and literature review

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Term Occurence Count Dictionary
abscess 3 infectiousdiseases
aspergillosis 26 infectiousdiseases
chloroquine 3 infectiousdiseasesdrugs
hydroxychloroquine 2 infectiousdiseasesdrugs
invasive aspergillosis 7 infectiousdiseases
AIDS 2 infectiousdiseases
Voriconazole 1 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Voriconazole 16872 Advancements in antifungal therapy have led to increased survival in patients with aspergillus infections. Voriconazole has better responses and improved survival compared to amphotericin B in invasive aspergillosis monotherapy
chloroquine 3371 for these diseases. But from November 2015, prednisone was switched to methylprednisolone, and hydroxy chloroquine has been added because of lupus nephritis aggravation, and tacrolimus has also been added to the medications
chloroquine 5720 400 mg per day as anti-aspergillosis therapy with 16 mg methylprednisolone and 400 mg hydroxy chloroquine per day as immunosuppressive therapy, along with a therapeutic 4100 iu q 12 h dose of nadroparin calcium.
chloroquine 6593 The patient is on a follow-up for 1 year and has been free of aspergillosis for 6 months. Hydroxy chloroquine treatment ceased in April 2017, and methylprednisolone dose was reduced in a tapered manner.Fig. 1Chest
hydroxychloroquine 3364 treatment for these diseases. But from November 2015, prednisone was switched to methylprednisolone, and hydroxychloroquine has been added because of lupus nephritis aggravation, and tacrolimus has also been added to the medications
hydroxychloroquine 5713 voriconazole dose 400 mg per day as anti-aspergillosis therapy with 16 mg methylprednisolone and 400 mg hydroxychloroquine per day as immunosuppressive therapy, along with a therapeutic 4100 iu q 12 h dose of nadroparin calcium.
Select Disease Character Offset Disease Term Instance
AIDS 9027 myelodysplastic syndrome (MDS) [[14], [20], [31], [32]]; 1 case suffered the acquired immune deficiency syndrome ( AIDS ) [[33]]; Another comorbidity was SLE in 5 patients (16.1%) [[8], [12], [13], [16], [18]] (Table 1).Table
AIDS 9412 glandLung/ airway12 (41.4)10 (34.5)7 (24.1)12 (41.4)13 (44.8)ComorbiditiesTransplantationSLEMDSNHLALLAML AIDS Chronic granulomatous diseasePolymyalgiaSkin diseaseDiabetesNo comorbidityn (%)9 (29.0)5 (16.1)4 (12.9)3
abscess 82 Title: BMC Infectious DiseasesA suppurative thyroiditis and perineal subcutaneous abscess related with aspergillus fumigatus: a case report and literature reviewJiaying TanJun ShenYong FangLiping
abscess 7037 nodesFig. 2Neck computed tomography revealed effective drainage of the left lobe of the thyroid gland while abscess es remained in the right lobeReview of the literatureTo explore thyroid or genital involved invasive
abscess 16234 drainage was effective and remained an integral component of therapy for resolution of the aspergillus abscess .Phagocytes, particularly neutrophils, play a critical role in the host’s defense against aspergillus.
aspergillosis 374 12/2018Publication date (pmc-release): 12/2018Publication date (collection): /2018AbstractBackgroundInvasive aspergillosis is a complication in immunocompromised patients and commonly detected in patients with hematological
aspergillosis 849 reports have described thyroid gland aspergilloses, most of which were due to disseminated invasive aspergillosis .Case presentationWe first report a case of thyroid gland and subcutaneous labium majus aspergillosis
aspergillosis 950 aspergillosis.Case presentationWe first report a case of thyroid gland and subcutaneous labium majus aspergillosis in a Chinese patient who received long-term glucocorticoid treatment for systemic lupus erythematosus
aspergillosis 1566 form of aspergillus infection in humans, accounting for 70–80% of these infections [[1]]. Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients such as those with
aspergillosis 2223 characterized by tissue invasion and secondary bloodstream dissemination [[4]]. The majority of thyroid aspergillosis cases are caused by disseminated invasive aspergillosis and are frequently diagnosed postmortem since
aspergillosis 2279 dissemination [[4]]. The majority of thyroid aspergillosis cases are caused by disseminated invasive aspergillosis and are frequently diagnosed postmortem since they can be apparently symptomless or the clinical appearance
aspergillosis 5646 because no further fluid was drained out. We continued the voriconazole dose 400 mg per day as anti- aspergillosis therapy with 16 mg methylprednisolone and 400 mg hydroxychloroquine per day as immunosuppressive
aspergillosis 6556 the clinical symptoms were relieved. The patient is on a follow-up for 1 year and has been free of aspergillosis for 6 months. Hydroxychloroquine treatment ceased in April 2017, and methylprednisolone dose was reduced
aspergillosis 7145 abscesses remained in the right lobeReview of the literatureTo explore thyroid or genital involved invasive aspergillosis in clinical practice, we collected the English literature up to June 2017 for all reports of aspergillosis
aspergillosis 7252 aspergillosis in clinical practice, we collected the English literature up to June 2017 for all reports of aspergillosis with thyroid or genital involvement through searches of MEDLINE, EMBASE, and Web of Science. Case reports
aspergillosis 7504 were excluded because of the immaturity of neonatal skin barrier and immune system. Key words were “ aspergillosis ”, “aspergillus”, “disseminated disease”, “extra-pulmonary aspergillosis”, “thyroid”,
aspergillosis 7588 Key words were “aspergillosis”, “aspergillus”, “disseminated disease”, “extra-pulmonary aspergillosis ”, “thyroid”, “perineum”, “aspergillus thyroiditis”, and “genital aspergillosis”. Finally,
aspergillosis 7683 “extra-pulmonary aspergillosis”, “thyroid”, “perineum”, “aspergillus thyroiditis”, and “genital aspergillosis ”. Finally, we found 36 articles describing aspergillus infections in 41 patients, from which 7 articles
aspergillosis 7849 aspergillus infections in 41 patients, from which 7 articles (7 patients) were diagnosed only with genital aspergillosis and 4 cases in an article [[6]] did not indicate aspergillus thyroiditis. A total of 29 articles describing
aspergillosis 11736 [[7], [11], [13], [14], [17], [18], [20], [24], [31], [33]] suffered from neutropenia at the moment of aspergillosis diagnosis. Furthermore, only 2 of the neutropenia patients survived [[17], [18]]. Aspergillus thyroiditis
aspergillosis 12599 aspergillus thyroiditis excluding dissemination [[25]].Probably many cases of genital involved disseminated aspergillosis were not reported, since it was a subset of cutaneous aspergillus infection. There were 7 reports of
aspergillosis 12744 a subset of cutaneous aspergillus infection. There were 7 reports of cutaneous and/or subcutaneous aspergillosis in the genital area identified in the literature [[34]–[40]]. Different from expectations, not all
aspergillosis 14537 the genital area. Although fungemia was never documented, the patient most likely had disseminated aspergillosis resulting from hematogenous spread. Pulmonary involvement had a strong possibility in this case considering
aspergillosis 15466 detecting aspergillus thyroiditis ante mortem. It also plays an important role in the diagnosis of aspergillosis involving skin and soft tissue, which could difficult to distinguish by the naked eye.Early diagnosis
aspergillosis 15585 involving skin and soft tissue, which could difficult to distinguish by the naked eye.Early diagnosis of aspergillosis and the establishment of aggressive therapy before more widespread dissemination of the infection likely
aspergillosis 15796 likely contributed to the successful treatment in this patient. A satisfactory outcome of invasive aspergillosis is predicated on the return of normal bone marrow function and the prompt starting of appropriate antifungal
aspergillosis 16403 the host’s defense against aspergillus. Studies have demonstrated that the incidence of invasive aspergillosis is directly related to the duration of neutropenia [[44]]. For disseminated disease, a reduction of
aspergillosis 16967 infections. Voriconazole has better responses and improved survival compared to amphotericin B in invasive aspergillosis monotherapy [[47]], while caspofungin has been widely used as an effective ‘rescue’ therapy [[48]].
aspergillosis 18412 lack of thyroid-related symptomatology, even with laboratory evidence of thyroid dysfunction.Invasive aspergillosis is a relatively frequent fungal infection occurred in immunocompromised patients, but aspergillus thyroiditis
aspergillosis 18777 patients treated with a novel azole, voriconazole, and an echinocandin, caspofungin. Early diagnosis of aspergillosis is a key to successful treatment. The clinicians must maintain a high level of diagnostic suspicion
aspergillosis 19224 complaints, since a number of patient conditions are asymptomatic in the initial stage of invasive aspergillosis
invasive aspergillosis 840 few case reports have described thyroid gland aspergilloses, most of which were due to disseminated invasive aspergillosis .Case presentationWe first report a case of thyroid gland and subcutaneous labium majus aspergillosis
invasive aspergillosis 2270 bloodstream dissemination [[4]]. The majority of thyroid aspergillosis cases are caused by disseminated invasive aspergillosis and are frequently diagnosed postmortem since they can be apparently symptomless or the clinical appearance
invasive aspergillosis 7136 abscesses remained in the right lobeReview of the literatureTo explore thyroid or genital involved invasive aspergillosis in clinical practice, we collected the English literature up to June 2017 for all reports of aspergillosis
invasive aspergillosis 15787 infection likely contributed to the successful treatment in this patient. A satisfactory outcome of invasive aspergillosis is predicated on the return of normal bone marrow function and the prompt starting of appropriate antifungal
invasive aspergillosis 16394 critical role in the host’s defense against aspergillus. Studies have demonstrated that the incidence of invasive aspergillosis is directly related to the duration of neutropenia [[44]]. For disseminated disease, a reduction of
invasive aspergillosis 16958 aspergillus infections. Voriconazole has better responses and improved survival compared to amphotericin B in invasive aspergillosis monotherapy [[47]], while caspofungin has been widely used as an effective ‘rescue’ therapy [[48]].
invasive aspergillosis 19215 subjective complaints, since a number of patient conditions are asymptomatic in the initial stage of invasive aspergillosis

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