Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate

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Annotation Summary

Term Occurence Count Dictionary
Japanese encephalitis 1 infectiousdiseases
dengue fever 1 infectiousdiseases
dengue hemorrhagic fever 2 infectiousdiseases
minocycline 4 infectiousdiseasesdrugs
tetracycline 1 infectiousdiseasesdrugs
vaccinia 1 infectiousdiseases
yellow fever 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
minocycline 18180 different cells, and most of these approaches fail in clinical trials [[89]]. Recently, we found that minocycline , a semi-synthetic tetracycline-derivative antibiotic, attenuates DENV replication through inhibition
minocycline 18381 inhibition of MIF secretion and autophagy formation both in vitro and in vivo [[90]]. In addition, minocycline treatment can prolong the survival of ICR suckling mice after DENV infection. Therefore, minocycline
minocycline 18482 minocycline treatment can prolong the survival of ICR suckling mice after DENV infection. Therefore, minocycline may modulate both virus replication and the host immune response. Further clinical trials of minocycline
minocycline 18587 minocycline may modulate both virus replication and the host immune response. Further clinical trials of minocycline in dengue patients may help to verify its therapeutic protection against DHF/DSS.Antibody against NS1
tetracycline 18210 these approaches fail in clinical trials [[89]]. Recently, we found that minocycline, a semi-synthetic tetracycline -derivative antibiotic, attenuates DENV replication through inhibition of MIF secretion and autophagy
Select Disease Character Offset Disease Term Instance
Japanese encephalitis 22752 acids (a.a.) 271-352bChimeric DJ NS1: consisting of N-terminal DENV NS1 (a.a. 1-270) and C-terminal Japanese encephalitis virus NS1 (a.a. 271-352)However, as previously described, many anti-NS1 Abs can cross-react with host
dengue fever 405 (DENV) infection is the most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage
dengue hemorrhagic fever 428 most common mosquito-transmitted viral infection. DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Hemorrhage and vascular leakage are two characteristic symptoms of
dengue hemorrhagic fever 1709 with fever and rash. However, a small proportion of cases develop into severe illness, which is termed dengue hemorrhagic fever (DHF). DHF is characterized by vascular leakage, thrombocytopenia, and coagulopathy [[2]]. Vascular
vaccinia 26709 DENV2 (NGC) from suckling mouse brain/i.c.CD188% survival; 35% reduction in morbidity[[98]]Recombinant vaccinia virusexpressed NS1100 IC50 of DENV4 (H241) or DENV2 (NGC)/i.c.BALB/c63-100% survival[[116]]rEC204-NS1N65
yellow fever 24163 dengue vaccine (CYD-TDV; Dengvaxia) contains DENV E and prM proteins from the four serotypes in the yellow fever 17D backbone and has been used to induce preventive humoral and cell-mediated immune responses [[101],

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