Prevalence, Risk Factors, and Pathophysiology of Dysglycemia among People Living with HIV in Sub-Saharan Africa

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Annotation Summary

Term Occurence Count Dictionary
stavudine 4 infectiousdiseasesdrugs
tenofovir 1 infectiousdiseasesdrugs
tuberculosis 1 infectiousdiseases
zidovudine 4 infectiousdiseasesdrugs
abacavir 1 infectiousdiseasesdrugs
efavirenz 2 infectiousdiseasesdrugs
lamivudine 2 infectiousdiseasesdrugs
nevirapine 2 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
abacavir 15744 older thymidine analogues (e.g., stavudine and zidovudine) compared to newer agents (e.g., lamivudine, abacavir , and tenofovir) [[84]–[86]]. Adipose tissue samples from lipoatrophic individuals treated with zidovudine
efavirenz 9627 remain relevant in the PLHIV population [[6]]. Male gender [[23], [24]], long-term ART use [[28], [31]], efavirenz versus nevirapine use [[24], [37]], and higher CD4 count [[24], [28]] were identified as risk factors
efavirenz 28984 history of DM or IGTART regimen in use was stavudine or zidovudine with lamivudine and nevirapine or efavirenz Older age (OR 1.04) and CD4 count (OR 1.001) also associated with prevalent dysglycemia but cutoffs not
lamivudine 15732 prevalent with older thymidine analogues (e.g., stavudine and zidovudine) compared to newer agents (e.g., lamivudine , abacavir, and tenofovir) [[84]–[86]]. Adipose tissue samples from lipoatrophic individuals treated
lamivudine 28955 underestimated by the exclusion of known history of DM or IGTART regimen in use was stavudine or zidovudine with lamivudine and nevirapine or efavirenzOlder age (OR 1.04) and CD4 count (OR 1.001) also associated with prevalent
nevirapine 9644 PLHIV population [[6]]. Male gender [[23], [24]], long-term ART use [[28], [31]], efavirenz versus nevirapine use [[24], [37]], and higher CD4 count [[24], [28]] were identified as risk factors in two studies each.
nevirapine 28970 exclusion of known history of DM or IGTART regimen in use was stavudine or zidovudine with lamivudine and nevirapine or efavirenzOlder age (OR 1.04) and CD4 count (OR 1.001) also associated with prevalent dysglycemia
stavudine 9862 Individual studies found associations between dysglycemia in PLHIV and protease inhibitor use [[23]], stavudine use [[37]], zidovudine use [[37]], and female sex [[27]]. Of note, we did not find studies in SSA PLHIV
stavudine 15674 respiratory chain efficiency in adipocytes, is more prevalent with older thymidine analogues (e.g., stavudine and zidovudine) compared to newer agents (e.g., lamivudine, abacavir, and tenofovir) [[84]–[86]].
stavudine 15864 tenofovir) [[84]–[86]]. Adipose tissue samples from lipoatrophic individuals treated with zidovudine or stavudine demonstrate higher macrophage infiltration and proinflammatory cytokine production; two features thought
stavudine 28926 group and may be underestimated by the exclusion of known history of DM or IGTART regimen in use was stavudine or zidovudine with lamivudine and nevirapine or efavirenzOlder age (OR 1.04) and CD4 count (OR 1.001)
tenofovir 15758 analogues (e.g., stavudine and zidovudine) compared to newer agents (e.g., lamivudine, abacavir, and tenofovir ) [[84]–[86]]. Adipose tissue samples from lipoatrophic individuals treated with zidovudine or stavudine
zidovudine 9884 associations between dysglycemia in PLHIV and protease inhibitor use [[23]], stavudine use [[37]], zidovudine use [[37]], and female sex [[27]]. Of note, we did not find studies in SSA PLHIV that identified an
zidovudine 15688 chain efficiency in adipocytes, is more prevalent with older thymidine analogues (e.g., stavudine and zidovudine ) compared to newer agents (e.g., lamivudine, abacavir, and tenofovir) [[84]–[86]]. Adipose tissue
zidovudine 15850 abacavir, and tenofovir) [[84]–[86]]. Adipose tissue samples from lipoatrophic individuals treated with zidovudine or stavudine demonstrate higher macrophage infiltration and proinflammatory cytokine production; two
zidovudine 28939 be underestimated by the exclusion of known history of DM or IGTART regimen in use was stavudine or zidovudine with lamivudine and nevirapine or efavirenzOlder age (OR 1.04) and CD4 count (OR 1.001) also associated
Select Disease Character Offset Disease Term Instance
tuberculosis 30791 PI: protease inhibitor; PLHIV: people living with HIV; PY: person-years; DM: diabetes mellitus; TB: tuberculosis . ∗Only statistically significant risk factors are reported. aPrediabetes definition: impaired fasting

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