Infection due to Mycoplasma hominis after left hip replacement: case report and literature review

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Term Occurence Count Dictionary
ofloxacin 3 infectiousdiseasesdrugs
Ceftazidime 1 infectiousdiseasesdrugs
hepatitis B 1 infectiousdiseases
hepatitis C 1 infectiousdiseases
levofloxacin 1 infectiousdiseasesdrugs
erythromycin 1 infectiousdiseasesdrugs
tetracycline 2 infectiousdiseasesdrugs
meningitis 1 infectiousdiseases
metronidazole 1 infectiousdiseasesdrugs
azithromycin 2 infectiousdiseasesdrugs
cefepime 1 infectiousdiseasesdrugs
ciprofloxacin 1 infectiousdiseasesdrugs
doxycycline 6 infectiousdiseasesdrugs
vancomycin 3 infectiousdiseasesdrugs
abscess 1 infectiousdiseases
cefazolin 1 infectiousdiseasesdrugs
clindamycin 8 infectiousdiseasesdrugs
moxifloxacin 10 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
Ceftazidime 11902 Approximately 400-ml light yellow, odorless effusion of the wound was drained.Antibiotic preventionCefazolin Ceftazidime , vancomycinVancomycinNANACefazolinAntibiotic treatment.Cefazolin was replaced by vancomycin. Later transferred
azithromycin 5898 revealed that the organism was susceptible to doxycycline, clindamycin and levofloxacin, but resistant to azithromycin by the bioMérieux® SA Mycoplasma IST2 kit (Biomerieux, France). Combination therapy with clindamycin
azithromycin 12146 into erythromycin, clindamycin and minocyline.Vancomycin, metronidazole.Vancomycin. Later switched to azithromycin , doxycycline, moxifloxacin.Cefazolin 500 mg of tetracycline iv every 8 h. After the first week,
cefazolin 12387 (200 mg/day), and over the next 3 weeks.Ciprofloxacin and clindamycin; subsequently changed to cefazolin and clindamycin, continued for 4 weeks; and later changed to moxifloxacin and rifampin for a presumed
cefepime 705 literature.Case presentationA 59-year-old male was febrile after left total hip replacement. Empiric therapy with cefepime for suspected infection was ineffective. Specimens at the infection site were collected for culture,
ciprofloxacin 16746 clindamycin, which often used for eradicating M. hominis with favorable results [[16]]. Quinolones ( ciprofloxacin or moxifloxacin) or tetracyclines (minocyline) are active against M. hominis and moxifloxacin appears
clindamycin 1058 diameter after 7-day incubation, and were identified as M. hominis. Sequentially, combination therapy with clindamycin hydrochloride and moxifloxacin was initiated, and the patient defervesced within 3 days and was discharged
clindamycin 5851 antimicrobial susceptibility testing (AST) revealed that the organism was susceptible to doxycycline, clindamycin and levofloxacin, but resistant to azithromycin by the bioMérieux® SA Mycoplasma IST2 kit (Biomerieux,
clindamycin 6002 azithromycin by the bioMérieux® SA Mycoplasma IST2 kit (Biomerieux, France). Combination therapy with clindamycin hydrochloride (0.6 g IV q12h) and moxifloxacin (400 mg IV QD) was initiated, as shown in Fig. 2.
clindamycin 12063 treatment.Cefazolin was replaced by vancomycin. Later transferred to the combination into erythromycin, clindamycin and minocyline.Vancomycin, metronidazole.Vancomycin. Later switched to azithromycin, doxycycline, moxifloxacin.Cefazolin
clindamycin 12350 first week, switched to oral doxycycline (200 mg/day), and over the next 3 weeks.Ciprofloxacin and clindamycin ; subsequently changed to cefazolin and clindamycin, continued for 4 weeks; and later changed to moxifloxacin
clindamycin 12401 (200 mg/day), and over the next 3 weeks.Ciprofloxacin and clindamycin; subsequently changed to cefazolin and clindamycin , continued for 4 weeks; and later changed to moxifloxacin and rifampin for a presumed chronic S. epidermidis
clindamycin 12647 with moxifloxacin was initiated, however the patient’s condition continued to deteriorate.Cefepime, clindamycin , moxifloxacin, and doxycycline.Blood cultureNegativeNegativeNegativeNegativeNegativeNegativeOutcomeRecoveryRecoveryRecoveryRecoveryDeadRecoveryWBC
clindamycin 16646 macrolide antibiotics due to the mutations in the 23S rRNA gene and is the only mycoplasma susceptible to clindamycin , which often used for eradicating M. hominis with favorable results [[16]]. Quinolones (ciprofloxacin
doxycycline 3812 after surgery). d Recovered after anti- M. hominis treatment with the combination of moxifloxacin, and doxycycline (18 days after surgery). e After 7 day of incubation of subcutaneous fluid collected during debridement
doxycycline 5838 sequencing.In vitro antimicrobial susceptibility testing (AST) revealed that the organism was susceptible to doxycycline , clindamycin and levofloxacin, but resistant to azithromycin by the bioMérieux® SA Mycoplasma IST2
doxycycline 12160 erythromycin, clindamycin and minocyline.Vancomycin, metronidazole.Vancomycin. Later switched to azithromycin, doxycycline , moxifloxacin.Cefazolin 500 mg of tetracycline iv every 8 h. After the first week, switched to oral
doxycycline 12276 moxifloxacin.Cefazolin 500 mg of tetracycline iv every 8 h. After the first week, switched to oral doxycycline (200 mg/day), and over the next 3 weeks.Ciprofloxacin and clindamycin; subsequently changed to cefazolin
doxycycline 12678 however the patient’s condition continued to deteriorate.Cefepime, clindamycin, moxifloxacin, and doxycycline .Blood cultureNegativeNegativeNegativeNegativeNegativeNegativeOutcomeRecoveryRecoveryRecoveryRecoveryDeadRecoveryWBC
doxycycline 17224 result [[16], [19]]. The patient in our case had the regimen of the combination of moxifloxacin and doxycycline and had positive response.In summary, the postoperative infection after hip replacement secondary to
erythromycin 12049 vancomycinVancomycinNANACefazolinAntibiotic treatment.Cefazolin was replaced by vancomycin. Later transferred to the combination into erythromycin , clindamycin and minocyline.Vancomycin, metronidazole.Vancomycin. Later switched to azithromycin, doxycycline,
levofloxacin 5867 susceptibility testing (AST) revealed that the organism was susceptible to doxycycline, clindamycin and levofloxacin , but resistant to azithromycin by the bioMérieux® SA Mycoplasma IST2 kit (Biomerieux, France). Combination
metronidazole 12102 vancomycin. Later transferred to the combination into erythromycin, clindamycin and minocyline.Vancomycin, metronidazole .Vancomycin. Later switched to azithromycin, doxycycline, moxifloxacin.Cefazolin 500 mg of tetracycline
moxifloxacin 1088 were identified as M. hominis. Sequentially, combination therapy with clindamycin hydrochloride and moxifloxacin was initiated, and the patient defervesced within 3 days and was discharged home.ConclusionsThe study
moxifloxacin 3794 palpation (8 days after surgery). d Recovered after anti- M. hominis treatment with the combination of moxifloxacin , and doxycycline (18 days after surgery). e After 7 day of incubation of subcutaneous fluid collected
moxifloxacin 6050 kit (Biomerieux, France). Combination therapy with clindamycin hydrochloride (0.6 g IV q12h) and moxifloxacin (400 mg IV QD) was initiated, as shown in Fig. 2. The patient defervesced within 3 days. His infection
moxifloxacin 12173 clindamycin and minocyline.Vancomycin, metronidazole.Vancomycin. Later switched to azithromycin, doxycycline, moxifloxacin .Cefazolin 500 mg of tetracycline iv every 8 h. After the first week, switched to oral doxycycline
moxifloxacin 12460 clindamycin; subsequently changed to cefazolin and clindamycin, continued for 4 weeks; and later changed to moxifloxacin and rifampin for a presumed chronic S. epidermidis infection. Treatment with moxifloxacin was initiated,
moxifloxacin 12550 changed to moxifloxacin and rifampin for a presumed chronic S. epidermidis infection. Treatment with moxifloxacin was initiated, however the patient’s condition continued to deteriorate.Cefepime, clindamycin, moxifloxacin,
moxifloxacin 12660 moxifloxacin was initiated, however the patient’s condition continued to deteriorate.Cefepime, clindamycin, moxifloxacin , and doxycycline.Blood cultureNegativeNegativeNegativeNegativeNegativeNegativeOutcomeRecoveryRecoveryRecoveryRecoveryDeadRecoveryWBC
moxifloxacin 16763 which often used for eradicating M. hominis with favorable results [[16]]. Quinolones (ciprofloxacin or moxifloxacin ) or tetracyclines (minocyline) are active against M. hominis and moxifloxacin appears to have the greatest
moxifloxacin 16841 Quinolones (ciprofloxacin or moxifloxacin) or tetracyclines (minocyline) are active against M. hominis and moxifloxacin appears to have the greatest activity as the most effective therapeutic agent. If M. hominis was correctly
moxifloxacin 17207 and a favorable result [[16], [19]]. The patient in our case had the regimen of the combination of moxifloxacin and doxycycline and had positive response.In summary, the postoperative infection after hip replacement
ofloxacin 5870 susceptibility testing (AST) revealed that the organism was susceptible to doxycycline, clindamycin and lev ofloxacin , but resistant to azithromycin by the bioMérieux® SA Mycoplasma IST2 kit (Biomerieux, France). Combination
ofloxacin 12336 After the first week, switched to oral doxycycline (200 mg/day), and over the next 3 weeks.Cipr ofloxacin and clindamycin; subsequently changed to cefazolin and clindamycin, continued for 4 weeks; and later
ofloxacin 16750 clindamycin, which often used for eradicating M. hominis with favorable results [[16]]. Quinolones (cipr ofloxacin or moxifloxacin) or tetracyclines (minocyline) are active against M. hominis and moxifloxacin appears
tetracycline 12208 metronidazole.Vancomycin. Later switched to azithromycin, doxycycline, moxifloxacin.Cefazolin 500 mg of tetracycline iv every 8 h. After the first week, switched to oral doxycycline (200 mg/day), and over the next
tetracycline 16780 eradicating M. hominis with favorable results [[16]]. Quinolones (ciprofloxacin or moxifloxacin) or tetracycline s (minocyline) are active against M. hominis and moxifloxacin appears to have the greatest activity as
vancomycin 11915 light yellow, odorless effusion of the wound was drained.Antibiotic preventionCefazolinCeftazidime, vancomycin VancomycinNANACefazolinAntibiotic treatment.Cefazolin was replaced by vancomycin. Later transferred to
vancomycin 11995 preventionCefazolinCeftazidime, vancomycinVancomycinNANACefazolinAntibiotic treatment.Cefazolin was replaced by vancomycin . Later transferred to the combination into erythromycin, clindamycin and minocyline.Vancomycin, metronidazole.Vancomycin.
vancomycin 16265 pathogens.Empiric therapy for postoperative infections generally includes agents such as beta-lactams and vancomycin that act on the bacterial cell wall. Such an initial therapy will show no efficacy against M. hominis
Select Disease Character Offset Disease Term Instance
abscess 13487 been associated with mycoplasma bacteraemia leading to the seeding of brain-damaged tissues in brain abscess cases [[5], [6], [9], [21]]. Similarly, in our case, a possible pathway might be indwelling catheter
hepatitis B 3266 postoperative period, as shown in Fig. 2. Furthermore, the screening tests for human immunodeficiency virus, hepatitis B virus and hepatitis C virus infections were non-reactive, and no abnormality in liver or renal function
hepatitis C 3288 in Fig. 2. Furthermore, the screening tests for human immunodeficiency virus, hepatitis B virus and hepatitis C virus infections were non-reactive, and no abnormality in liver or renal function tests was observed.
meningitis 1740 infections outside the genitourinary tract occurred rarely. However, to date, wound infection [[4]], meningitis [[5]], postoperative infections [[6]–[9]] and other disseminated infections in immunocompromised patients

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