Liver as a target of human immunodeficiency virus infection

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Annotation Summary

Term Occurence Count Dictionary
AIDS 2 infectiousdiseases
hepatitis B 1 infectiousdiseases
hepatitis C 1 infectiousdiseases
nevirapine 1 infectiousdiseasesdrugs
stavudine 1 infectiousdiseasesdrugs
viral hepatitis 2 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
nevirapine 7620 with ART might be hepatotoxic, and especially this is a case for the old drugs, like azidothymidine, nevirapine and nucleoside analogs[[33]-[35]]. Previous observational data investigating risks for death suggested
stavudine 8031 patients, but conversely, was protective for advanced fibrosis in HCV-coinfected patients. Didanosine and stavudine were identified as being of particular risk for fibrosis in both HIV-monoinfected and HCV-coinfected
Select Disease Character Offset Disease Term Instance
AIDS 4197 liver damageLiver disease is now recognized as the most common non-acquired immune deficiency syndrome ( AIDS ) related cause of death among HIV-infected patients and accounts for 14%-18% of all deaths in this group[[6]-[8]].
AIDS 5918 Previously, HIV-related liver injury was interpreted as a consequence of opportunistic infections or AIDS -induced malignancies, but recent data indicate that HIV itself may affect the liver. In HIV-monoinfected
hepatitis B 4682 prominent when HIV patients are co-infected with hepatotropic viruses [hepatitis C virus (HCV) and hepatitis B virus (HBV)] or are exposed to liver-damaging substances, such as alcohol[[11]]. Thus, managing the
hepatitis C 4654 of liver injury is even more prominent when HIV patients are co-infected with hepatotropic viruses [ hepatitis C virus (HCV) and hepatitis B virus (HBV)] or are exposed to liver-damaging substances, such as alcohol[[11]].
viral hepatitis 5438 transaminases are frequently elevated in the sera of HIV-infected patients even in the absence of accompanying viral hepatitis [[18]]. In addition, there is an association between HIV RNA content and liver fibrosis[[19]].Liver manifestations
viral hepatitis 6681 epidemiological studies reported that HIV directly induces liver fibrinogenesis[[25],[26]] in patients without viral hepatitis co-infection. A large North American clinical investigation demonstrated that HIV RNA plasma levels

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