Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism

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Term Occurence Count Dictionary
AIDS 2 infectiousdiseases
Japanese encephalitis 2 infectiousdiseases
hepatitis A 2 infectiousdiseases
hepatitis B 3 infectiousdiseases
hepatitis C 2 infectiousdiseases
infectious disease 1 infectiousdiseases
mumps 2 infectiousdiseases
diarrhea 2 infectiousdiseases
hepatitis E 2 infectiousdiseases
herpes simplex 2 infectiousdiseases
molluscum contagiosum 2 infectiousdiseases
vaccinia 2 infectiousdiseases

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Select Disease Character Offset Disease Term Instance
AIDS 33686 escape mechanism that suppress NF-κB activity in different life cycles, we chose a single virus, HIV-1. AIDS is a highly harmful infectious disease caused by HIV-1, which attacks CD4+ T cells and destroys host
AIDS 33993 evasion by inhibiting NF-κB in productive and latent infections will be beneficial for controlling AIDS . In productive infections, HIV-1 infects activated CD4+ T cells. Upon entry, HIV-1 goes through reverse
Japanese encephalitis 22957 nuclear import of NF-κB is mediated by nuclear transport receptors, such as importin α and importin β. Japanese encephalitis virus (JEV) NS5 protein [[68]] and Hantaan virus (HTNV) nucleocapsid (N) protein [[69]] interact with
Japanese encephalitis 48382 HBV, hepatitis B virus; HCV, hepatitis C virus; HEV, hepatitis E virus; HBoV, human bocavirus; JEV, Japanese encephalitis virus; IAV, influenza A virus; CSFV, classical swine fever virus; RV, rotavirus; PEDV, porcine epidemic
diarrhea 19799 degradation of IκBα are necessary for releasing NF-κB to enter the nucleus. Thus, the porcine epidemic diarrhea virus (PEDV) NSP1 inhibits the phosphorylation and subsequent degradation of IκBα and blocks p65 nuclear
diarrhea 48508 virus; IAV, influenza A virus; CSFV, classical swine fever virus; RV, rotavirus; PEDV, porcine epidemic diarrhea virus; PRRSV, porcine reproductive and respiratory syndrome virus; HTNV, Hantaan virus; CoV, coronavirus;
hepatitis A 27502 Q343 [[82]]. The foot-and-mouth disease virus (FMDV) 3C protease cleaves NEMO at Q383 [[84]], and the hepatitis A virus (HAV) 3C protease cleaves at Q304 [[85]]. The 3C-like (3CL) proteases NSP4 of PRRSV and NSP5 of
hepatitis A 48263 coxsackievirus B3; EV71, enterovirus 71; EV68, enterovirus 68; FMDV, foot-and-mouth disease virus; HAV, hepatitis A virus; HBV, hepatitis B virus; HCV, hepatitis C virus; HEV, hepatitis E virus; HBoV, human bocavirus;
hepatitis B 13212 (HSV-1) nuclear protein ICP0 [[26]], the classical swine fever virus (CSFV) NS3 protein [[27]], the hepatitis B virus (HBV) X protein (HBX) [[28]], and the coronavirus (CoV) helper protein open reading frame-9b (ORF-9b)
hepatitis B 16174 NEMO by targeting NEMO to autophagosomes for subsequent degradation in the lysosomes [[34]]. However, hepatitis B e antigen (HBeAg), a nucleocapsid protein of HBV, specifically interacts with the TIR proteins Mal and
hepatitis B 48287 enterovirus 71; EV68, enterovirus 68; FMDV, foot-and-mouth disease virus; HAV, hepatitis A virus; HBV, hepatitis B virus; HCV, hepatitis C virus; HEV, hepatitis E virus; HBoV, human bocavirus; JEV, Japanese encephalitis
hepatitis C 17527 by LUBAC-mediated linear polyubiquitylation is required for the efficient activation of NF-κB. The hepatitis C virus (HCV) nonstructural protein NS3 competes with the binding of NEMO for binding to LUBAC, which
hepatitis C 48311 enterovirus 68; FMDV, foot-and-mouth disease virus; HAV, hepatitis A virus; HBV, hepatitis B virus; HCV, hepatitis C virus; HEV, hepatitis E virus; HBoV, human bocavirus; JEV, Japanese encephalitis virus; IAV, influenza
hepatitis E 12189 detailed mechanism for the regulation of MyD88 RNA synthesis require further investigation. Additionally, hepatitis E virus (HEV) open reading frame 3 (ORF3) encodes a protein that blocks the NF-κB signaling pathway through
hepatitis E 48335 foot-and-mouth disease virus; HAV, hepatitis A virus; HBV, hepatitis B virus; HCV, hepatitis C virus; HEV, hepatitis E virus; HBoV, human bocavirus; JEV, Japanese encephalitis virus; IAV, influenza A virus; CSFV, classical
herpes simplex 13089 proteasome pathway, blocking the NF-κB signaling pathway, and is employed by KSHV RTA [[24],[25]], the herpes simplex virus-1 (HSV-1) nuclear protein ICP0 [[26]], the classical swine fever virus (CSFV) NS3 protein [[27]],
herpes simplex 47866 dephosphorylate IKKsNEMO[[111],[112]]* Abbreviation of each virus is given in the first column of Table 1. HSV-1, herpes simplex virus-1; VZV, varicella-zoster virus; SVV, simian varicella virus; HCMV, human cytomegalovirus; MCMV,
infectious disease 33711 NF-κB activity in different life cycles, we chose a single virus, HIV-1. AIDS is a highly harmful infectious disease caused by HIV-1, which attacks CD4+ T cells and destroys host immune function, seriously threatening
molluscum contagiosum 17770 LUBAC-mediated linear ubiquitylation of NEMO, and thus inhibits the activation of NF-κB [[40]]. However, the molluscum contagiosum virus (MCV) MC005 protein binds to NEMO in a specific region where NEMO binds IKKα/β, thus inhibiting
molluscum contagiosum 48814 gastroenteritis virus; hMPV, human metapneumovirus; MuV, mumps virus; HIV-1, human immunodeficiency virus 1; MCV, molluscum contagiosum virus; VACV, vaccinia virus; ORFV, Orf virus; ECTV, ectromelia virus; MCPyV, Merkel cell polyomavirus
mumps 32626 [[111],[112]].4.5. SH Protein Encoded by VirusesThe encoded SH proteins of paramyxoviruses, such as the mumps virus (MuV) [[113],[114]], simian virus 5 (SV5) [[113]], respiratory syncytial virus (RSV) [[115],[116]],
mumps 48757 syndrome coronavirus; TGEV, transmissible gastroenteritis virus; hMPV, human metapneumovirus; MuV, mumps virus; HIV-1, human immunodeficiency virus 1; MCV, molluscum contagiosum virus; VACV, vaccinia virus;
vaccinia 18083 chains and preventing IKKβ phosphorylation [[41]]. Additionally, MC159 [[42]], another MCV protein, the vaccinia virus (VACV) protein C4 [[43]], and the Orf virus (ORFV)-encoded protein ORFV073 [[44]] all interact
vaccinia 48849 metapneumovirus; MuV, mumps virus; HIV-1, human immunodeficiency virus 1; MCV, molluscum contagiosum virus; VACV, vaccinia virus; ORFV, Orf virus; ECTV, ectromelia virus; MCPyV, Merkel cell polyomavirus

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