Humanized Mice as Unique Tools for Human-Specific Studies.

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Term Occurence Count Dictionary
hepatitis C 2 infectiousdiseases
infectious disease 5 infectiousdiseases
malaria 4 infectiousdiseases
tuberculosis 4 infectiousdiseases
vaccinia 1 infectiousdiseases
dexamethasone 1 infectiousdiseasesdrugs
hepatitis B 2 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
dexamethasone 47236 mice and were important to lupus development. Similar to patients, when these mice were treated with dexamethasone , spleen weight, and proteinuria decreased. Mice with a human immune system xenografted with patient
Select Disease Character Offset Disease Term Instance
hepatitis B 26956 humanization of the liver in humanized mice to support the study of hepatotropic pathogens such as hepatitis B virus and hepatitis C virus (HCV) (Bility et al. [16]; Keng et al. [87]; Strick-Marchand et al. [146];
hepatitis B 35975 VZV showed lesions of varicellaMoffat et al. ([108])DENV Dengue virus, EBV Epstein–Barr virus, HBV hepatitis B virus, HCV hepatitis C virus, hAdV human adenovirus, hCMV human cytomegalovirus, HIV human immunodeficiency
hepatitis C 26978 liver in humanized mice to support the study of hepatotropic pathogens such as hepatitis B virus and hepatitis C virus (HCV) (Bility et al. [16]; Keng et al. [87]; Strick-Marchand et al. [146]; Tan-Garcia et al. [151];
hepatitis C 35998 varicellaMoffat et al. ([108])DENV Dengue virus, EBV Epstein–Barr virus, HBV hepatitis B virus, HCV hepatitis C virus, hAdV human adenovirus, hCMV human cytomegalovirus, HIV human immunodeficiency virus, HTLV1 human
infectious disease 1087 significant promise to become a panacea for drug innovations to treat and control conditions such as infectious disease and cancer. This review will focus on the background of humanized mice, diseases, and human-specific
infectious disease 3079 not limited to, cancer (Her et al. [71]; Ito et al. [80]; Miyakawa et al. [107]; Pan et al. [118]), infectious disease (Amaladoss et al. [3]; Frias-Staheli et al. [58]; Keng et al. [87]; Yajima et al. [181]), autoimmune
infectious disease 7660 et al. [28]; Pearson et al. [120]), autoimmunity (Gunawan et al. [66]; Viehmann Milam et al. [166]), infectious disease (Keng et al. [87]; Lüdtke et al. [100]; Wege et al. [175]), cancer biology (Chang et al. [35]; Her
infectious disease 21916 researchers to understand important factors that facilitate the development of medical issues including infectious disease , cancer, autoimmunity, and GvHD. Currently, a mouse model that completely mimics every single human
infectious disease 22389 DiseaseSince the invention of humanized mice, multitudinous attempts have been made to recapitulate infectious disease s within these mice. A particular human-specific infectious pathogen that has been successfully studied
malaria 24822 human-specific infectious pathogen studied on humanized mice, Plasmodium falciparum, is a causative agent of malaria (Amaladoss et al. [3]; Carlton et al. [31]; Chen et al. [38]; Good et al. [61]; Jiménez-Díaz et al.
malaria 25015 Jiménez-Díaz et al. [83]; Soulard et al. [143]; Vaughan et al. [165]). For years, our understanding of malaria had been impeded by the lack of human-specific small animal models which can be infected by highly host-specific
malaria 25366 immunological disease pathogenesis observed in patients. Due to this, most in vivo experimental studies of malaria were conducted in rodents with mouse or rat-specific Plasmodium strains (Goodman et al. [62]). Differences
malaria 34159 ([175])MalariaNewborn NSG intracardially injected with human CD34+ UBC cell and intravenously infected with malaria NSG mice were supplemented human erythropoietin and IL-3 via hydrodynamic tail-vein injection. Human
tuberculosis 27918 et al. [87]).Other examples of infectious pathogens studied on humanized mice include, Mycobacterium tuberculosis (Calderon et al. [30]; Nusbaum et al. [114]), influenza (Yu et al. [186]; Zheng et al. [191]), Borrelia
tuberculosis 34812 IL-6, G-CSF, and GM-CSF which commonly causes acute lung injuryValbuena et al. ([160])Mycobacterium tuberculosis NSG mice engrafted with human fetal thymus and liver tissue under the kidney capsule and intravenously
tuberculosis 35033 injected with CD34+ FL cells to create huBLT mice. These mice were intranasally infected with tdTomato M. tuberculosis H37RvMice infected with M. tuberculosis demonstrated progressive bacterial infection within the lung
tuberculosis 35073 mice. These mice were intranasally infected with tdTomato M. tuberculosis H37RvMice infected with M. tuberculosis demonstrated progressive bacterial infection within the lung which disseminated to the spleen and liver.
vaccinia 45272 (1935-MEL and 888-MEL)Mice were successfully engrafted with a functional human immune system. Oncolytic vaccinia virus therapy, particularly CTLA4 scAb increased CD56+ NK cells and decreased virus titersTsoneva et

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