Mycetoma: a clinical dilemma in resource limited settings

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Annotation Summary

Term Occurence Count Dictionary
abscess 2 infectiousdiseases
paracoccidioidomycosis 1 infectiousdiseases
blastomycosis 3 infectiousdiseases
sulfamethoxazole 5 infectiousdiseasesdrugs
terbinafine 1 infectiousdiseasesdrugs
typhus 1 infectiousdiseases
infectious disease 2 infectiousdiseases
leprosy 1 infectiousdiseases
plague 2 infectiousdiseases
sporotrichosis 1 infectiousdiseases
trimethoprim 5 infectiousdiseasesdrugs
amikacin 1 infectiousdiseasesdrugs
chromoblastomycosis 1 infectiousdiseases
coccidioidomycosis 3 infectiousdiseases
lobomycosis 1 infectiousdiseases
phaeohyphomycosis 1 infectiousdiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
amikacin 23858 [[49]]Antifungals (ketoconazole, voriconazole, posaconazole, etc.)Antibiotics (sulfamethoxazole–trimethoprim, rifampicin, amikacin , etc.)Recurrence [[1]]MoreLessTable 4Infectious and non-infectious diseases mimicking mycetoma: consideration
sulfamethoxazole 23813 [[1]]OccassionalFrequentDrugs (e.g.) [[49]]Antifungals (ketoconazole, voriconazole, posaconazole, etc.)Antibiotics ( sulfamethoxazole –trimethoprim, rifampicin, amikacin, etc.)Recurrence [[1]]MoreLessTable 4Infectious and non-infectious
sulfamethoxazole 25743 treatment modalities are available. In Weilsh regimen, 15 mg/kg IM of Amikacin in two divided doses + sulfamethoxazole (35 mg/kg/day) and trimethoprim (7 mg/kg/day) in three divided doses for 21 days at 1–3 cycles
sulfamethoxazole 25956 cycles of 15-days intervals is used in the intensive phase. In its maintenance phase, trimethoprim and sulfamethoxazole (7 and 35 mg/kg/day, respectively) are administered for 2 weeks after the last cycle [[18]]. In modified
sulfamethoxazole 26136 2 weeks after the last cycle [[18]]. In modified Welsh, 15 mg/kg/day of Amikacin in divided doses + sulfamethoxazole –trimethoprim tablets (35 + 7 mg/kg/day) + rifampicin capsule (10 mg/kg/day) for 21 days
sulfamethoxazole 26329 (10 mg/kg/day) for 21 days at 1–3 cycles of 15 days intervals in the intensive phase is followed by sulfamethoxazole –trimethoprim tablets (35 + 7 mg/kg/day) + rifampicin capsule (10 mg/kg/day) for 3 months
terbinafine 27185 ketoconazole (400 mg/day), voriconazole 400–600 mg/day, posaconazole (200 mg, four times daily), terbinafine (500–1000 mg/day), and amphotericin B (0.5–1.25 mg/kg/day) alone or with any combination(s) [[49]].Recommendation
trimethoprim 23832 [[49]]Antifungals (ketoconazole, voriconazole, posaconazole, etc.)Antibiotics (sulfamethoxazole– trimethoprim , rifampicin, amikacin, etc.)Recurrence [[1]]MoreLessTable 4Infectious and non-infectious diseases mimicking
trimethoprim 25780 Weilsh regimen, 15 mg/kg IM of Amikacin in two divided doses + sulfamethoxazole (35 mg/kg/day) and trimethoprim (7 mg/kg/day) in three divided doses for 21 days at 1–3 cycles of 15-days intervals is used in the
trimethoprim 25939 21 days at 1–3 cycles of 15-days intervals is used in the intensive phase. In its maintenance phase, trimethoprim and sulfamethoxazole (7 and 35 mg/kg/day, respectively) are administered for 2 weeks after the last
trimethoprim 26155 cycle [[18]]. In modified Welsh, 15 mg/kg/day of Amikacin in divided doses + sulfamethoxazole– trimethoprim tablets (35 + 7 mg/kg/day) + rifampicin capsule (10 mg/kg/day) for 21 days at 1–3 cycles
trimethoprim 26348 21 days at 1–3 cycles of 15 days intervals in the intensive phase is followed by sulfamethoxazole– trimethoprim tablets (35 + 7 mg/kg/day) + rifampicin capsule (10 mg/kg/day) for 3 months in the maintenance
Select Disease Character Offset Disease Term Instance
abscess 15640 to actual measurementsEarly phase of mycetomaAt early onset of the disease, a papule, a nodule, an abscess or just an induration lacking a clear margin can be seen. At this point, a meticulous history may reveal
abscess 24570 tumours Lobomycosis Osteosarcoma Paracoccidioidomycosis Rhabdomyosarcoma Phaeohyphomycosis Sarcomas (others) Sporotrichosis Subdermal abscess Occupational PodoconiosisDisease names are given in alphabetical orderTable 5Level of health care facilities
blastomycosis 21976 superimposed by bacterial infection [[69], [70]]. Fungal diseases such as botryomycosis, sporotrichosis, blastomycosis , chromoblastomycosis, coccidioidomycosis, phaeohyphomycosis, lobomycosis and paracoccidioidomycosis
blastomycosis 21997 infection [[69], [70]]. Fungal diseases such as botryomycosis, sporotrichosis, blastomycosis, chromo blastomycosis , coccidioidomycosis, phaeohyphomycosis, lobomycosis and paracoccidioidomycosis have close resemblance
blastomycosis 24360 cyst Yaws Giant cell tumourFungal Gouty typhus Blastomycosis Kaposi’s sarcoma Botryomycosis Lipomas Chromo blastomycosis Malignant melanoma Coccidioidomycosis Nerve sheath tumours Lobomycosis Osteosarcoma Paracoccidioidomycosis Rhabdomyosarcoma Phaeohyphomycosis Sarcomas
chromoblastomycosis 21991 bacterial infection [[69], [70]]. Fungal diseases such as botryomycosis, sporotrichosis, blastomycosis, chromoblastomycosis , coccidioidomycosis, phaeohyphomycosis, lobomycosis and paracoccidioidomycosis have close resemblance
coccidioidomycosis 22012 [[69], [70]]. Fungal diseases such as botryomycosis, sporotrichosis, blastomycosis, chromoblastomycosis, coccidioidomycosis , phaeohyphomycosis, lobomycosis and paracoccidioidomycosis have close resemblance to mycetoma [[71]].
coccidioidomycosis 22071 sporotrichosis, blastomycosis, chromoblastomycosis, coccidioidomycosis, phaeohyphomycosis, lobomycosis and para coccidioidomycosis have close resemblance to mycetoma [[71]]. Knowledge of their epidemiology and clinical progression
coccidioidomycosis 24468 sarcoma Botryomycosis Lipomas Chromoblastomycosis Malignant melanoma Coccidioidomycosis Nerve sheath tumours Lobomycosis Osteosarcoma Para coccidioidomycosis Rhabdomyosarcoma Phaeohyphomycosis Sarcomas (others) Sporotrichosis Subdermal abscessOccupational PodoconiosisDisease
infectious disease 23924 etc.)Antibiotics (sulfamethoxazole–trimethoprim, rifampicin, amikacin, etc.)Recurrence [[1]]MoreLessTable 4Infectious and non- infectious disease s mimicking mycetoma: consideration for differential diagnosisInfectious diseasesNon-infectious diseasesParasiticTumours Elephantiasis Acral
infectious disease 24027 non-infectious diseases mimicking mycetoma: consideration for differential diagnosisInfectious diseasesNon- infectious disease sParasiticTumours Elephantiasis Acral melanomaBacterial Bone cyst Actinomycosis Fibro lipomas Chronic
leprosy 3100 partner among young adults and accelerates the rate of drop outs from school in children [[1]]. Just like leprosy , in which stigma affects many dimensions of victim’s life [[3]], mycetoma is also plagued by various
lobomycosis 22051 botryomycosis, sporotrichosis, blastomycosis, chromoblastomycosis, coccidioidomycosis, phaeohyphomycosis, lobomycosis and paracoccidioidomycosis have close resemblance to mycetoma [[71]]. Knowledge of their epidemiology
paracoccidioidomycosis 22067 sporotrichosis, blastomycosis, chromoblastomycosis, coccidioidomycosis, phaeohyphomycosis, lobomycosis and paracoccidioidomycosis have close resemblance to mycetoma [[71]]. Knowledge of their epidemiology and clinical progression
phaeohyphomycosis 22032 diseases such as botryomycosis, sporotrichosis, blastomycosis, chromoblastomycosis, coccidioidomycosis, phaeohyphomycosis , lobomycosis and paracoccidioidomycosis have close resemblance to mycetoma [[71]]. Knowledge of their
plague 2463 eumycetoma from actinomycetoma. There is an urgent need for research funding for mycetoma, a disease plague d by severe physical disabilities and social stigma leading to isolation.Electronic supplementary materialThe
plague 3193 Just like leprosy, in which stigma affects many dimensions of victim’s life [[3]], mycetoma is also plague d by various socio-economic consequences [[4]]. Though uncertainty hovers on its actual global incidence,
sporotrichosis 21960 except when superimposed by bacterial infection [[69], [70]]. Fungal diseases such as botryomycosis, sporotrichosis , blastomycosis, chromoblastomycosis, coccidioidomycosis, phaeohyphomycosis, lobomycosis and paracoccidioidomycosis
typhus 24287 osteomyelitis Fibroma Syphilis Foreign body granuloma Tuberculosis Ganglion cyst Yaws Giant cell tumourFungal Gouty typhus Blastomycosis Kaposi’s sarcoma Botryomycosis Lipomas Chromoblastomycosis Malignant melanoma Coccidioidomycosis Nerve

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