A systematic review of adherence to oral pre-exposure prophylaxis for HIV - how can we improve uptake and adherence?

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Term Occurence Count Dictionary
tenofovir 7 infectiousdiseasesdrugs
AIDS 5 infectiousdiseases

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Select Drug Character Offset Drug Term Instance
tenofovir 4236 prophylaxis (PrEP) in MSM, finding a 44% risk reduction in the experimental group receiving daily oral tenofovir -emtricitabine (TDF-FTC) as compared to placebo [[6]]. This success has since been replicated in several
tenofovir 10925 UgandaHeterosexual HIV-discordant couples1147807Convenience sub-cohort of a RDBPCTDailyTDF-FTC01414TDF02013Bangkok tenofovir study [[31]]BangkokPWID24139665RDBPCTDailyTDF1733502013Uganda safety and adherence study [[35]]UgandaHeterosexual
tenofovir 12954 drugs, RCT randomised controlled trial, RDBPCT randomised, double blinded, placebo controlled trial, TDF tenofovir , FTC emtricitabineAdherenceTable 2 describes reported study adherence by various measures. Wide disparity
tenofovir 13215 count, medication event monitoring system) and intrusive (levels of TDF and/or FTC in plasma samples, or tenofovir diphosphate measured in dried blood spots) measures of adherence. In all measured cases, a higher proportion
tenofovir 14542 adherence substudy [[17]]Kenya and UgandaHeterosexual HIV-discordant couplesDaily–––99972013Bangkok tenofovir study [[31]]BangkokPWIDDaily673994––2013Uganda safety and adherence study [[35]]UgandaHeterosexual
tenofovir 18498 TDF62.2% (21.5 to 83.4)2012FEM-PrEP [[13]]Heterosexual FemalesDailyTDF-FTC6% (−52 to 41%)2013Bangkok tenofovir study [[31]]PWIDDailyTDF48.9% (9.6 to 72.2)2014iPrEx extension [[15]]MSM/TGWDailyTDF-FTC36% (−24 to
tenofovir 18968 intention to treat. MSM men who have sex with men, TGW transgender women, PWID people who inject drugs, TDF tenofovir , FTC emtricitabineThree main oral dosing regimen options have been investigated (Fig. 2). Daily dosing
Select Disease Character Offset Disease Term Instance
AIDS 2429 2015 compared to less than 10% the decade before [[1]]. This translates into a 26% reduction in global AIDS -related deaths since 2010. Additionally, with the efficacy of treatment as prevention demonstrated in
AIDS 2720 people already infected. However, despite these advances, the Joint United Nations Programme on HIV/ AIDS (UNAIDS) notes that recent headway in HIV incidence reduction has slowed “alarmingly”, and that
AIDS 2728 already infected. However, despite these advances, the Joint United Nations Programme on HIV/AIDS (UN AIDS ) notes that recent headway in HIV incidence reduction has slowed “alarmingly”, and that disparities
AIDS 7171 August 2016, and repeated in September 2017. In addition, we searched conference abstracts from the AIDS Conference, International AIDS Society Conference and the Conference on Retroviruses and Opportunistic
AIDS 7202 September 2017. In addition, we searched conference abstracts from the AIDS Conference, International AIDS Society Conference and the Conference on Retroviruses and Opportunistic Infections via their online

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