The Use of Liquids Ionic Fluids as Pharmaceutically Active Substances Helpful in Combating Nosocomial Infections Induced by New Delhi Strain, and Species

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Term Occurence Count Dictionary
vancomycin 3 infectiousdiseasesdrugs
ampicillin 1 infectiousdiseasesdrugs
erythromycin 1 infectiousdiseasesdrugs
hepatitis B 1 infectiousdiseases
meropenem 2 infectiousdiseasesdrugs
pneumonia 23 infectiousdiseases
sulfamethoxazole 1 infectiousdiseasesdrugs
trimethoprim 2 infectiousdiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

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Select Drug Character Offset Drug Term Instance
ampicillin 36390 bactericidal properties of ILs can be modified by the addition of an appropriate antibiotic molecule, e.g., ampicillin , to the anion part of ILs [[39],[48]]. Application of ILs eliminates the issue of drug resistance [[95]].
erythromycin 6048 thermodynamic properties is their ability to form multiphase systems, which has been used for the liquid-liquid erythromycin antibiotic extraction [[20]]. An important feature of ILs is their melting temperature and the ease
meropenem 39700 grafts [[100]]. Despite the introduction of new antibiotics for treatment, including vancomycin and meropenem , the mortality rate from staphylococcal infections has not changed over the last five years [[90]].
meropenem 43932 immunosuppressive treatment [[107]]. The New Delhi K. pneumoniae strain is resistant to treatment with meropenem and other carbapenems due to the extended spectrum of β-lactamase produced by this strain, containing
sulfamethoxazole 44519 current drug regimen presupposes the use of colistin, aminoglycosides and trimethoprim together with sulfamethoxazole . Colistin is characterized by high nephrotoxicity, and the use of aminoglycosides is associated with
trimethoprim 44492 propagation [[109]]. The current drug regimen presupposes the use of colistin, aminoglycosides and trimethoprim together with sulfamethoxazole. Colistin is characterized by high nephrotoxicity, and the use of aminoglycosides
trimethoprim 44677 nephrotoxicity, and the use of aminoglycosides is associated with an irreversible cytotoxic effect, while trimethoprim is characterized by a dose-dependent effect [[108],[109]]. Hence, the drug concentrations used in humans
vancomycin 39083 and in endodontic treatment. The described complexes are characterized by particular activity against vancomycin -resistant [VRE] Enterococcus strains, which are VRE alert strains [[98]].Staphylococcus aureus is currently
vancomycin 39685 vascular stent grafts [[100]]. Despite the introduction of new antibiotics for treatment, including vancomycin and meropenem, the mortality rate from staphylococcal infections has not changed over the last five
vancomycin 41635 unachievable even for the most effective antibiotics (0.25 μg mL−1 vs. 2–3 μg mL−1 in blood serum for vancomycin ), [[102],[104]]. Mono, di, and tri-formylation of TPA is obtained in the Vilsmeier-Hack reaction. The
Select Disease Character Offset Disease Term Instance
hepatitis B 18491 transmitted in surgical wards [[51]]. Difficulties in combating viruses were associated with massive hepatitis B and C virus infection outbreaks (HBV, HCV) in the 1980′s and 1990′s of the 20th century [[53]].
pneumonia 1856 applications in nosocomial infections. Dedicated attention is given to finding infections with the Klebsiella pneumonia e New Delhi strain, Acinetobacter baumannii, and Enterococcus species, which are responsible for the
pneumonia 28764 puteana, and Trametes versicolor) were susceptible to quaternary ammonium halides [[71]].Klebsiella pneumonia e deserves special attention. Bacteria from the Klebsiella genus are Gram (−) enterobacteria of the
pneumonia 29276 infections, liver, sepsis, soft tissue infections, and peritonitis. It was also described as the cause of pneumonia for the first time. K. pneumoniae is the most frequently isolated species of the Klebsiella genus in
pneumonia 29309 infections, and peritonitis. It was also described as the cause of pneumonia for the first time. K. pneumonia e is the most frequently isolated species of the Klebsiella genus in Poland (about 95% of isolates) [[72]].
pneumonia 29643 described in the first part of this article, the most dangerous from the medicinal point of view is K. pneumonia eNew Delhi metallo-β-lactamase-1 (NDM-1) strain infection. New Delhi metallo-β-lactamase type 1 is
pneumonia 30077 sensitivity to monobactams remains [[73]]. Strains exhibiting such a resistance mechanism, named KPC (K. pneumonia e carbapenemase), were characterized recently in Poland, Italy, and other EU countries [[73]]. To date,
pneumonia 30259 EU countries [[73]]. To date, 16 different genes encoding carbapenemase have been identified in K. pneumonia e [[74]]. The object of the widest research is currently KPC-2 and KPC-3, coded by the blaKPC-2 and blaKPC-3
pneumonia 30394 the widest research is currently KPC-2 and KPC-3, coded by the blaKPC-2 and blaKPC-3 genes [[75]]. K. pneumonia e bacteria are usually resistant to penicillins because the production of β-lactamases is encoded by
pneumonia 31161 the assembly of other resistance genes in their cells in the near future. NDM-1 was identified in K. pneumonia e and E. coli, and was isolated in 2008 in a hospital patient in New Delhi (India) from a patient diagnosed
pneumonia 32255 Belgium in June 2010 in an ICU patient [[79]].ILs may constitute the first line of defense against K. pneumonia e NDM-1 infections [[80],[81]]. The first work on the impact of the organic anion showed that ILs are
pneumonia 34921 microorganisms constituting a danger for social health: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia e, Acinetobacter baumannii, and Pseudomonas aeruginosa, collectively referred to by the acronym ESKAPE
pneumonia 35352 Disease Control and Prevention (CDC, the USA), infection with Escherichia coli (E. coli) and Klebsiella pneumonia e strains resistant to treatment with third generation cephalosporins are treated as a threat to public
pneumonia 43383 cationic channel leading to a change in the transmembrane potential, and eventually, cell death [[74]].K. pneumonia e New Delhi has been a widespread pathogen in Asia since its discovery in 2008 in India [[105]]. A troubling
pneumonia 43561 discovery in 2008 in India [[105]]. A troubling problem is infections with pathogens such as the Klebsiella pneumonia e New Delhi strain, which produces metallo-β-lactamase-1 (NDM), and until now, was considered exotic
pneumonia 43694 which produces metallo-β-lactamase-1 (NDM), and until now, was considered exotic in Europe [[106]]. K. pneumonia e NDM causes pneumonia, sepsis and soft tissue inflammation in humans and in transplant recipients due
pneumonia 43716 metallo-β-lactamase-1 (NDM), and until now, was considered exotic in Europe [[106]]. K. pneumoniae NDM causes pneumonia , sepsis and soft tissue inflammation in humans and in transplant recipients due to hospitalization and
pneumonia 43883 transplant recipients due to hospitalization and immunosuppressive treatment [[107]]. The New Delhi K. pneumonia e strain is resistant to treatment with meropenem and other carbapenems due to the extended spectrum
pneumonia 44838 [[108],[109]]. Hence, the drug concentrations used in humans have only bacteriostatic action against K. pneumonia e NDM. ILs have a bactericidal effect against the K. pneumoniae NDM strain [[107]]. The most effective
pneumonia 44900 only bacteriostatic action against K. pneumoniae NDM. ILs have a bactericidal effect against the K. pneumonia e NDM strain [[107]]. The most effective method against this strain turned out to be the use of biopolymer
pneumonia 45791 [[38],[70]]. Moreover, a nanocomposite filler, laponite, allowed a stronger bactericidal effect against K. pneumonia e NDM, which was observed according to the bacterial inhibition zone (BIZ) on agar plates [[51]]. The
pneumonia 46232 compounds enable the topical use of the compounds in medicine as dressings for wounds infected with K. pneumonia e NDM. In addition, the matrix may form a scaffolding for the growth of granulation tissue and promote
pneumonia 53879 [[75],[80],[85],[87],[89],[90]].ijms-19-02779-t002_Table 2Table 2Listing of bacterial priority strains including S. aureus, Enterococcus species, K. pneumonia e, Enterobacteriaceae and P. aeruginosa, antibiotic resistance mechanisms and ionic liquids showing the
pneumonia 55463 peptidoglycan7.17.1 **[C18Im]8.18.1 **[BMIm+Cl-]7.57.5 **Ag+C3H5N2-p5.7 × 10−105.7 × 10−10 **Klebsiella pneumonia eATCC4352Metallo-β-lactamse-1[C2mim][Cl]Inhibition of acetylcholineesetrase178263[[51],[96]][CBP]Interaction

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