Dengue infection in India: A systematic review and meta-analysis

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dengue fever 161 India: A systematic review and meta-analysisAlternative Title: Systematic review and meta-analysis of dengue fever in IndiaParasuraman Ganeshkumar (Conceptualization) (Data curation) (Investigation) (Methodology) (Project
dengue fever 1829 incidence and geographic distribution is critical in planning appropriate control measures against dengue fever . We conducted a systematic review and meta-analysis of dengue fever in IndiaMethodsWe searched for studies
dengue fever 1897 appropriate control measures against dengue fever. We conducted a systematic review and meta-analysis of dengue fever in IndiaMethodsWe searched for studies published until 2017 reporting the incidence, the prevalence
dengue fever 5222 genus. As per the WHO 1997 classification, symptomatic dengue virus infection has been classified into dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). The revised WHO classification
dengue fever 6074 earlier, but is now also reported from peri-urban as well as rural areas [[4],[5]]. Surveillance for dengue fever in India is conducted through a network of more than 600 sentinel hospitals under the National Vector
dengue fever 7377 this background, we conducted a systematic review and meta-analysis to estimate the disease burden of dengue fever in India. We also reviewed serotype distribution of dengue viruses in circulation, and estimated case
dengue fever 8819 their abstracts reported incidence, prevalence, number of reported cases, mortality or the burden of dengue fever anywhere in India. Studies reporting complications of dengue, serotype details of dengue virus as well
dengue fever 15007 the review are provided in the PRISMA flowchart (Fig 1). None of the studies reported incidence of dengue fever .10.1371/journal.pntd.0006618.g001Fig 1Flow diagram showing the article selection in the systematic review
dengue fever 15209 systematic review on dengue in India.Primary outcomesPrevalence (proportion) of laboratory confirmed dengue fever Of the 233 studies included in the analysis, 180 provided information about proportion of laboratory
dengue fever 16199 definitions such as acute febrile illness/acute undifferentiated illness (n = 20), and clinically suspected dengue fever (n = 93). Similarly, of the 26 reported outbreaks, investigators used WHO or NVBDCP case definitions
dengue fever 16402 definitions in 7 and 2 settings respectively, whereas acute febrile illness and clinically suspected dengue fever case definitions were used in 5 and 12 settings respectively.Place and time distribution of studies:
dengue fever 21655 (n = 1) and neighbourhood contacts of dengue confirmed cases (n = 1). The overall seroprevalence of dengue fever based on these studies was 56.9% (95% CI: 37.5–74.4) (Fig 4). The age-specific prevalence of IgG antibodies
dengue fever 29312 consistent for all study outcomes. (S3 Appendix)DiscussionThe present study has estimated the burden of dengue fever based on published literature from India spanning over five decades. Most of the published literature
dengue fever 29997 in the public domain.There was no community-based epidemiological study reporting the incidence of dengue fever . Our analysis revealed that among the clinically suspected dengue fever patients, the estimated prevalence
dengue fever 30069 reporting the incidence of dengue fever. Our analysis revealed that among the clinically suspected dengue fever patients, the estimated prevalence of laboratory-confirmed dengue infection was 38%. The burden of dengue
dengue fever 31014 seroprevalence of dengue in the general population is a useful indicator for measuring endemicity of dengue fever . The dengue vaccine (CYD-TDV) manufactured by Sanofi Pasteur has been introduced in two sub-national
dengue fever 36225 geographic regions of the country in order to generate reliable estimates of age-specific incidence of dengue fever in India. As such studies are cost intensive, a national level survey to estimate age-stratified dengue

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