Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis.

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Term Occurence Count Dictionary
hand, foot and mouth disease 7 infectiousdiseases
herpangina 1 infectiousdiseases
meningitis 2 infectiousdiseases
pneumonia 1 infectiousdiseases

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hand, foot and mouth disease 3103 specific funding for this study. See below for researcher funding.Author-highlightsHighlights•Severe hand, foot and mouth disease (HFMD) is associated with CNS involvement.•Severe HFMD is associated with a significant burden of
hand, foot and mouth disease 7527 Appendix 1] in English using the validated hedge term for children[21]; descriptions of the exposure ( hand, foot and mouth disease , enterovirus A71 and all other permutations); of outcome as concept (e.g. follow-up, outcome); and of
hand, foot and mouth disease 14548 G, Li Z, et al. Clinical features and neuropsychological development follow up on 126 patients with hand, foot and mouth disease and encephalitis. General Practice of Chinese Medicine. 2015;13(4):607–8.B – Zhang Q, MacDonald
hand, foot and mouth disease 14974 Diseases Journal. 2014 May;33(5):482–7.C – Lou Y, Jin H, Liang P. Follow-up analysis of severe hand, foot and mouth disease in 33 cases caused by enterovirus 71. Chinese Medical Science. 2013;13:211–2.D – Liu K, Ma X, Zhang
hand, foot and mouth disease 15436 Wang Y, Wang X, et al. Two-year clinical follow-up study in patients with acute flaccid paralysis of hand, foot and mouth disease . General Practice of China. 2011;14(20):2260–3.F – Peng B, Du Z, Li X, et al. Evolution and prognosis
hand, foot and mouth disease 15791 2012;50(4):255–60.G – Zhang S, Jia L, Li G. Clinical analysis and follow-up on eight children with hand, foot and mouth disease and acute flaccid paralysis. Modern Practical Medicine. 2013;25(7):806–8.H – Fu S, Luo X, Wen X,
hand, foot and mouth disease 15990 2013;25(7):806–8.H – Fu S, Luo X, Wen X, et al. Clinical analysis and follow-up study in children with severe hand, foot and mouth disease . General Practice of China. 2014;17(4):403–7.I – W.C. Shen, H.H. Chiu, K.C. Chow and C.H. Tsai,
herpangina 3598 of fever and vesicular rash on the palmar and plantar aspects of the hands and feet with or without herpangina , ulcers on the buccal mucosa. HFMD outbreaks, seen in preschool children, are usually benign and self-limiting.
meningitis 4882 15–30% of adults die,[12] validating its recent description as “the new polio”.[13],[14].Aseptic meningitis , brainstem encephalitis, encephalomyelitis, cerebellar ataxia, AFP and life threatening cardiopulmonary
meningitis 24307 follow-up after severe HFMD was 80.2% (95% CI: 68.7%, 89.8%), comparable to outcomes following bacterial meningitis where full recovery is seen in 83.6% (developed countries) and 73.5% (developing countries) of children
pneumonia 21254 independent risk factor for gastrostomy. Long-term NG tube feeding complicated by recurrent aspiration pneumonia is also described.[31],[37].Other outcomes described in grade IV disease includes seizures, sometimes

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