Recent advances in understanding and managing sepsis

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Annotation Summary

Term Occurence Count Dictionary
meningitis 1 infectiousdiseases
pneumonia 4 infectiousdiseases
septic shock 15 infectiousdiseases

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meningitis 6968 give an answer to the key question of why some patients (for instance, in cases of severe pneumonia or meningitis due to Streptococcus pneumoniae) react excessively in terms of hyper-inflammation and “cytokine storm”
pneumonia 6955 does not give an answer to the key question of why some patients (for instance, in cases of severe pneumonia or meningitis due to Streptococcus pneumoniae) react excessively in terms of hyper-inflammation and
pneumonia 7000 of why some patients (for instance, in cases of severe pneumonia or meningitis due to Streptococcus pneumonia e) react excessively in terms of hyper-inflammation and “cytokine storm” (see below) whereas others
pneumonia 8273 (“dysregulated”) by, for example, other infections, pregnancy, splenectomy (in case of Streptococcus pneumonia e), or older age. Interestingly, in many of those cases where this disease tolerance fails, the clinical
pneumonia 21246 urinary tract infection with subsequent sepsis is associated with a lower mortality compared with severe pneumonia [28]. Finally, the microorganism’s virulence and bacterial load may influence the prognosis of sepsis [29].Based
septic shock 911 parallel, huge data analyses confirmed these research insights with a new way to define sepsis and septic shock (called “Sepsis-3”), which led to discussions within the scientific community. In addition to these
septic shock 1414 result, new “bundles” were initiated with the goal of enabling standardized management of sepsis and septic shock , especially in the very early phase. This short commentary provides a brief overview of these two major
septic shock 2680 Barcelona, Barcelona, Spain No competing interests were disclosed.IntroductionCurrently, sepsis and septic shock with subsequent multi-organ failure are the leading causes of death in adult intensive care units (ICUs).
septic shock 4939 the Surviving Sepsis Campaign (SSC) has developed several guidelines for the management of sepsis and septic shock . From 2005 to 2010, “sepsis bundles” were tested to demonstrate that a protocolized approach in
septic shock 6658 induced [6]. The lungs, kidneys, and cardiovascular system are the most affected organs during sepsis and septic shock [7]. This, however, is based on clinical assessment of organ function by routine biomarkers and might
septic shock 10516 definition of sepsis. The experts reached the following conclusions:1. The current concepts of sepsis and septic shock seem, in principle, useful for clinical routine and research.2. These definitions, however, do not allow
septic shock 12722 its criteria (organ dysfunction) are already included in the new definition of sepsis. The term “ septic shock ” remains; however, it now also includes an elevated lactate level of more than 2 mmol/L as an additional
septic shock 13592 despite adequate fluid management) and the serum lactate levels are more than 2 mmol/L, one speaks of “ septic shock ”. Sepsis-3 also provides a new tool meant as a simplified screening tool for early recognition of
septic shock 17160 measurement). According to the initial plan, these bundles were tested in more than 30,000 cases of sepsis and septic shock worldwide over a period of 5 years (2005–2010). As a result, it was demonstrated that (1) the planned
septic shock 17863 clinical behavior, improve quality of care, and may decrease mortality in patients with severe sepsis and septic shock ” [23]. Recently, a German group published data, again from a 7.5-year period using a hospital-supported
septic shock 18323 development in sepsis managementThe aforementioned improvement in survival of patients with sepsis and septic shock by standardized protocols and related control instruments (“standard operating procedures”, “check
septic shock 18830 state hospitals have to implement evidence-informed protocols for the fast management of sepsis and septic shock (New York Codes, Rules, and Regulations parts 405.2 and 405.4). The way this was carried out could be
septic shock 20095 and lactate measurement, whereas the effect of early fluid administration was demonstrated only in septic shock patients with a need for vasopressor administration [25]. This latter point supports current discussions
septic shock 22215 from the earliest chart annotation consistent with all elements of sepsis (formerly severe sepsis) or septic shock ascertained through chart review.Since these new bundles were published very recently, no validation
septic shock 23030 a higher rate of resistance against antibiotics over time.Closing remarksIn patients with sepsis or septic shock , a better understanding of the host response leading to the clinical course, a faster detection of high-risk

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