Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis.

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brucellosis 951 in electronic databases up to December 2017 identified as relating to the clinical features of human brucellosis in China. Only eight studies had sufficient quality for data extraction. Meta-analysis showed a significantly
brucellosis 1119 data extraction. Meta-analysis showed a significantly decreased proportion of CD4+ T cells in human brucellosis patients compared to healthy subject individuals. The frequency of CD8+ T cells was significantly higher
brucellosis 1245 compared to healthy subject individuals. The frequency of CD8+ T cells was significantly higher in human brucellosis patients than that in the healthy control group. The pooled analysis presented a significant decrease
brucellosis 1391 control group. The pooled analysis presented a significant decrease of the CD4+/CD8+ ratio in human brucellosis patients compared to healthy subjects. There is immunologic dysfunction of T lymphocyte in patients
brucellosis 1514 compared to healthy subjects. There is immunologic dysfunction of T lymphocyte in patients with human brucellosis , the CD4+ and CD8+ T cells might be the important factors affecting the progress of brucellosis.1. IntroductionBrucellosis
brucellosis 1610 human brucellosis, the CD4+ and CD8+ T cells might be the important factors affecting the progress of brucellosis .1. IntroductionBrucellosis is one of the most common zoonotic infections globally [[1]], which is a
brucellosis 1756 of the most common zoonotic infections globally [[1]], which is a highly contagious zoonosis. Human brucellosis is transmitted to humans by direct/indirect contact with infected animals or through the consumption
brucellosis 2281 Brucella has brought great harm to public health, food safety, and so on. The specific pathogenesis of brucellosis infection is not very clear. It is difficult to make a diagnosis by epidemiological and clinical symptoms.
brucellosis 2406 not very clear. It is difficult to make a diagnosis by epidemiological and clinical symptoms. Human brucellosis is prone to multiple system complications, and once the brucellosis progresses to chronic phase, it
brucellosis 2474 epidemiological and clinical symptoms. Human brucellosis is prone to multiple system complications, and once the brucellosis progresses to chronic phase, it will be difficult to cure [[7]]. Therefore, the pathogenesis of brucellosis
brucellosis 2582 brucellosis progresses to chronic phase, it will be difficult to cure [[7]]. Therefore, the pathogenesis of brucellosis is a hot research issue, and it is also believed that brucella infection is related to both innate immunity
brucellosis 2855 the changes of T lymphocyte are crucial to the interpretation of the clinicopathological features of brucellosis in the process of chronic infection and recurrence [[9], [10]]. There are three mechanisms of acquired
brucellosis 4103 different.There are few reports about the changes of peripheral blood T cell subsets in patients with brucellosis , and the results reported are not consistent [[15]–[22]]. It is difficult to draw a conclusion because
brucellosis 4656 patients and provide the direction for further exploration of the mechanism of the immune pathogenesis of brucellosis .2. Methods2.1. Search StrategyWe performed a systematic review of the literature to identify articles
brucellosis 4846 literature to identify articles relating to the changes of peripheral blood T cell subsets in patients with brucellosis . With the assistance of a professional medical librarian, we electronically searched for the literature
brucellosis 5040 searched for the literature in Wanfang Data, PubMed, and EMbase with MESH and keyword subject headings “ brucellosis ,” “Brucella,” “Brucel∗,” and “malta fever,” and “CD3,” “CD4,” “CD8,” “Th17,”
brucellosis 6019 investigators.Studies with the following criteria were excluded such as (i) articles related to nonhuman brucellosis , (ii) reported data that overlapped with already included articles, (iii) articles could not provide
brucellosis 6480 study, (ii) the literatures assessed the changes in peripheral blood T cell subsets in patients with brucellosis , and (iii) provided sufficient data, including mean and standard deviation of T cell from case and control
brucellosis 8569 criteria for data extraction and final analyses. Eight studies representing 396 patients with human brucellosis and 212 cases of healthy control were finally included in the meta-analysis. All 8 articles included
brucellosis 9425 Table 1.3.2. Changes of Peripheral Blood CD3+ T CellSeven studies including 346 patients with human brucellosis and 162 cases of healthy control, in which provided the data of the changes of peripheral blood CD3+
brucellosis 9555 healthy control, in which provided the data of the changes of peripheral blood CD3+ T cells in human brucellosis patients. Two studies reported that the proportions of CD3+ T cells in human brucellosis patients were
brucellosis 9644 cells in human brucellosis patients. Two studies reported that the proportions of CD3+ T cells in human brucellosis patients were significantly increased compared to control individuals [[15], [19]], while another 5
brucellosis 10154 random effects model was used. A meta-analysis showed that the proportions of CD3+ T cells in human brucellosis patients were increased but no significant difference between patients and control individuals ([MD = 1.6265,
brucellosis 10908 CellChanges of peripheral blood CD4+ T cells were reported by 8 trials, containing 396 patients with human brucellosis and 212 cases of healthy control. In the 8 studies we selected, 6 studies reported that proportions
brucellosis 11045 control. In the 8 studies we selected, 6 studies reported that proportions of CD4+ T cells in human brucellosis patients were significantly decreased compared to control individuals [[15]–[17], [19], [20], [22]];
brucellosis 11549 applied.Results of the meta-analysis showed a significantly decreased proportion of CD4+ T cells in human brucellosis patients compared to healthy subject individuals ([MD = −9.03, 95% CI (−12.93; −5.14), p <
brucellosis 12127 df = 6, p = 0.5708).3.4. Changes of Peripheral Blood CD8+ T CellEight trails with 396 patients with human brucellosis and 212 cases of healthy control reported changes of peripheral blood CD8+ T cell. These trials show
brucellosis 12522 analysis. Meta-analysis showed that there is a significantly increased proportion of CD8+ T cell in human brucellosis patients compared to healthy subject individuals ([MD = 5.24, 95% CI (2.99; 7.50), p < 0.0001]).
brucellosis 12718 7.50), p < 0.0001]). Five studies reported significantly increased proportions of CD8+ T cells in human brucellosis patients compared to control individuals [[15], [16], [19], [20], [22]]; the other 3 studies showed
brucellosis 13385 [[15], [16], [19], [20]] provided data of the changes of peripheral blood CD4+/CD8+ ratio in human brucellosis patients compared to controls including 291 patients with human brucellosis and 141 cases of healthy
brucellosis 13461 CD4+/CD8+ ratio in human brucellosis patients compared to controls including 291 patients with human brucellosis and 141 cases of healthy control. The trials showed homogeneity in the consistency of the trial results
brucellosis 13812 In the 4 studies we selected, each of them reported significantly decreased CD4+/CD8+ ratio in human brucellosis patients compared to control individuals. Results of the meta-analysis showed a significantly decreased
brucellosis 13964 individuals. Results of the meta-analysis showed a significantly decreased proportion of CD4+/CD8+ ratio human brucellosis patients compared to healthy individuals ([MD = −0.6291, 95% CI (−0.99, −0.27), p = 0.0006]).
brucellosis 14285 of peripheral blood Th1 cell were also reported by 3 trials, which included 99 patients with human brucellosis and 85 cases of healthy control. In the 3 studies we selected, 1 reported significantly increased proportion
brucellosis 14428 control. In the 3 studies we selected, 1 reported significantly increased proportion of Th1 cells in human brucellosis patients compared to control individuals [[16]], 1 reported significantly decreased proportion of Th1
brucellosis 14556 compared to control individuals [[16]], 1 reported significantly decreased proportion of Th1 cell in human brucellosis patients compared to control individuals [[17]], and the rest of the 1 study found that there were no
brucellosis 15027 effects model was used. Results of the meta-analysis showed increased proportions of Th1 cells in human brucellosis patients but no significant difference between patients and control individuals ([MD = 4.51, 95%
brucellosis 15357 Peripheral Blood Th2 CellThere are 3 articles providing data of the changes of peripheral Th2 cells in human brucellosis patients compared to controls including 99 patients with human brucellosis and 85 cases of healthy control.
brucellosis 15432 peripheral Th2 cells in human brucellosis patients compared to controls including 99 patients with human brucellosis and 85 cases of healthy control. In the 3 studies we selected, 1 reported significantly increased proportion
brucellosis 15575 control. In the 3 studies we selected, 1 reported significantly increased proportion of Th2 cells in human brucellosis patients compared to control individuals [[16]]; the rest of the 2 studies found that there were no
brucellosis 16031 statistical analysis. Results of the meta-analysis showed increased proportions of Th2 cell in human brucellosis patients but no significant difference between patients and control individuals ([MD = 0.93, 95%
brucellosis 16257 3.07), p = 0.3925]). The forest plot for these analyses was shown in Figure 7.4. DiscussionAlthough brucellosis is a disease that can be cured, there are still 5%~15% of brucellosis progression to chronicity with
brucellosis 16327 Figure 7.4. DiscussionAlthough brucellosis is a disease that can be cured, there are still 5%~15% of brucellosis progression to chronicity with characteristics of a typical clinical manifestation, chronic fatigue
brucellosis 16688 are more than 50 million new infections in the world every year. In recent years, the prevalence of brucellosis infection in China has also increased significantly [[25]]. Chinese CDC data showed that the annual
brucellosis 18318 found that the proportion of T lymphocytes secreting interferon-gamma in peripheral blood of chronic brucellosis patients was significantly lower than that in patients with acute stage, while the proportion of T lymphocytes
brucellosis 18665 in patients with chronic phase suggest that CD4+ T lymphocyte dysfunction is associated with chronic brucellosis . The proportions of CD4+ and CD8+ T lymphocytes in peripheral blood of patients with acute brucellosis
brucellosis 18768 brucellosis. The proportions of CD4+ and CD8+ T lymphocytes in peripheral blood of patients with acute brucellosis were not significantly different from that of healthy controls, while the proportion of CD8+ T lymphocytes
brucellosis 18936 controls, while the proportion of CD8+ T lymphocytes increased significantly in patients with chronic brucellosis , especially in patients with recurrent or symptomatic symptoms. But only a few CD8+ T lymphocytes secrete
brucellosis 19522 (without CD8+ T lymphocytes), indicating that CD8+ T lymphocytes play a major role in the immunity against brucellosis infection [[33]]. However, immunological studies on the interaction between host and brucella are mostly
brucellosis 19961 overall level of cellular immunity. By testing the changes of T lymphocyte subsets in 142 patients of brucellosis and 45 healthy controls, Gao et al. [[15]] has found that CD3+ T lymphocytes are increased in patients
brucellosis 20081 healthy controls, Gao et al. [[15]] has found that CD3+ T lymphocytes are increased in patients with brucellosis . Çelik et al. [[19]] reported that the proportion of CD3+ T lymphocytes in peripheral blood of patients
brucellosis 20209 [[19]] reported that the proportion of CD3+ T lymphocytes in peripheral blood of patients with acute brucellosis was significantly increased. Some other researches showed that the numbers of peripheral blood CD3+
brucellosis 20373 showed that the numbers of peripheral blood CD3+ T lymphocytes had no significant difference between brucellosis patients and healthy controls. This study showed that CD3+ T cells in human brucellosis patients had
brucellosis 20461 difference between brucellosis patients and healthy controls. This study showed that CD3+ T cells in human brucellosis patients had increased but there were no significant difference between patients and control individuals.
brucellosis 21706 in the percentage of CD4+ T, CD8+ T, and CD4+ T/CD8+ T ratios in peripheral blood in patients with brucellosis are not consistent. According to the results of the rat model, it is conjectured that the CD8+ T lymphocyte
brucellosis 22085 ineffective CD4+ T lymphocyte response by increasing the number of CD8+ T lymphocyte in patients with chronic brucellosis . Some studies reported that the CD4+ T lymphocyte proliferation reaction ability in patients with chronic
brucellosis 22203 studies reported that the CD4+ T lymphocyte proliferation reaction ability in patients with chronic brucellosis was significantly lower than that of the healthy controls and the acute patients [[40]]. This study
brucellosis 22359 healthy controls and the acute patients [[40]]. This study shows that the frequency of CD4+ T cells in brucellosis patients is lower than that of healthy controls, while the CD8 cell frequency is higher than that of
brucellosis 22627 control group, which shows that there is immunologic dysfunction of the T lymphocyte in patients with brucellosis . Further research is needed to confirm the changes of CD4+ and CD8+ T cell function in peripheral blood
brucellosis 22760 needed to confirm the changes of CD4+ and CD8+ T cell function in peripheral blood of patients with brucellosis .Th1 and Th2 cells are the first classified CD4+ T cell functional subgroups. Th1 cells mainly mediate
brucellosis 23738 shown that immune response induced by Th1 cells is necessary for highly effective vaccines to prevent brucellosis . Therefore, the increase of Th2 cell level in host cells may inhibit the immune response of Th1 cells
brucellosis 23927 immune response of Th1 cells and break the balance between Th1 and Th2 cells, leading the occurrence of brucellosis [[46]]. This study shows that proportions of Th1 and Th2 cells increased in human brucellosis patients
brucellosis 24021 occurrence of brucellosis [[46]]. This study shows that proportions of Th1 and Th2 cells increased in human brucellosis patients but neither of them has significant difference between patients and control individuals. The
brucellosis 24550 cells and their CD25high and FoxP3high subsets increase significantly in the peripheral blood of human brucellosis , with this increase being greater in the chronic group [[48]]. By contrast, Ganji at al. found a significantly
brucellosis 25203 ineffective to control the B. canis infection [[51]]. There were no reports on Th17 in patients with brucellosis .Our study has some limitations. First, heterogeneities exist among the included documents, which may
brucellosis 25736 with the formulas, leading to the failure to do more accurate analysis for the different stages of the brucellosis patients. Last, due to the quantity of the included literature is not enough, the subgroup analyses
brucellosis 25964 tested.In summary, we found that there was immunologic dysfunction of T lymphocyte in patients with human brucellosis , which may provide some pieces of evidence for immune regulation therapy of brucellosis. More high-quality
brucellosis 26052 with human brucellosis, which may provide some pieces of evidence for immune regulation therapy of brucellosis . More high-quality and large sample experiments are needed to further confirm the relationship between
brucellosis 26254 relationship between the frequency and function of peripheral blood T cells subsets and the pathogenesis of brucellosis .Figure 1Procedure of the selection process.Figure 2Forest plot of the changes of peripheral blood CD3+
brucellosis 26385 of the selection process.Figure 2Forest plot of the changes of peripheral blood CD3+ T cell in human brucellosis patients compared with controls.Figure 3Forest plot of the changes of peripheral blood CD4+ T cell in
brucellosis 26505 compared with controls.Figure 3Forest plot of the changes of peripheral blood CD4+ T cell in human brucellosis patients compared with controls.Figure 4Forest plot of the changes of peripheral blood CD8+ T cell in
brucellosis 26625 compared with controls.Figure 4Forest plot of the changes of peripheral blood CD8+ T cell in human brucellosis patients compared with controls.Figure 5Forest plot of the changes of peripheral blood CD4+/CD8+ ratio
brucellosis 26749 compared with controls.Figure 5Forest plot of the changes of peripheral blood CD4+/CD8+ ratio in human brucellosis patients compared with controls.Figure 6Forest plot of the changes of peripheral blood Th1 cell in human
brucellosis 26866 patients compared with controls.Figure 6Forest plot of the changes of peripheral blood Th1 cell in human brucellosis patients compared with controls.Figure 7Forest plot of the changes of peripheral blood Th2 cell in human
brucellosis 26983 patients compared with controls.Figure 7Forest plot of the changes of peripheral blood Th2 cell in human brucellosis patients compared with controls.Table 1Characteristics of studies included in the meta-analysis.YearAuthor(s)RegionTreatment
malaria 2101 more serious conditions in different organ systems [[4]–[6]]. Brucellosis is often misdiagnosed as malaria , typhoid fever, rheumatic fever, osteoarthritis, and other diseases. Brucella has brought great harm
typhoid fever 2110 serious conditions in different organ systems [[4]–[6]]. Brucellosis is often misdiagnosed as malaria, typhoid fever , rheumatic fever, osteoarthritis, and other diseases. Brucella has brought great harm to public health,

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